The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ltb4r2  -  leukotriene B4 receptor 2

Mus musculus

Synonyms: 5830462O07Rik, BLT2, Blt2, LTB4-R 2, LTB4-R-2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ltb4r2

  • The disease severity correlated well with histopathology, including loss of joint architecture, inflammatory cell infiltration, fibrosis, pannus formation, and bone erosion in joints of BLT1/BLT2(+/+) animals and a total absence of disease pathology in leukotriene receptor-deficient mice [1].
  • Chinese hamster ovary cells expressing BLT2 exhibit LTB(4)-induced chemotaxis, calcium mobilization, and pertussis toxin-insensitive inhibition of adenylyl cyclase [2].

High impact information on Ltb4r2

  • BLT2 is expressed ubiquitously, in contrast to BLT1, which is expressed predominantly in leukocytes [2].
  • Several BLT1 antagonists, including U 75302, failed to inhibit LTB(4) binding to BLT2 [2].
  • BLT2 is highly homologous to BLT1, with an amino acid identity of 45.2%, and its open reading frame is located in the promoter region of the BLT1 gene [2].
  • Leukotriene B(4) mediates diverse inflammatory diseases through the G protein-coupled receptors BLT1 and BLT2 [1].
  • These data suggest the presence of functional BLT2 in primary keratinocytes [3].

Biological context of Ltb4r2


Anatomical context of Ltb4r2

  • Northern blot analysis showed that mouse BLT2 is expressed highly in small intestine and skin in contrast to the ubiquitous expression of human BLT2 [3].
  • Thus, BLT2 is a pharmacologically distinct receptor for LTB(4), and may mediate cellular functions in tissues other than leukocytes [2].

Analytical, diagnostic and therapeutic context of Ltb4r2


  1. Targeted Disruption of Leukotriene B4 Receptors BLT1 and BLT2: A Critical Role for BLT1 in Collagen-Induced Arthritis in Mice. Shao, W.H., Del Prete, A., Bock, C.B., Haribabu, B. J. Immunol. (2006) [Pubmed]
  2. A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., Shimizu, T. J. Exp. Med. (2000) [Pubmed]
  3. Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. Iizuka, Y., Yokomizo, T., Terawaki, K., Komine, M., Tamaki, K., Shimizu, T. J. Biol. Chem. (2005) [Pubmed]
  4. Leukotriene B4: metabolism and signal transduction. Yokomizo, T., Izumi, T., Shimizu, T. Arch. Biochem. Biophys. (2001) [Pubmed]
WikiGenes - Universities