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Ltb4r2  -  leukotriene B4 receptor 2

Mus musculus

Synonyms: 5830462O07Rik, BLT2, Blt2, LTB4-R 2, LTB4-R-2, ...
 
 
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Disease relevance of Ltb4r2

  • The disease severity correlated well with histopathology, including loss of joint architecture, inflammatory cell infiltration, fibrosis, pannus formation, and bone erosion in joints of BLT1/BLT2(+/+) animals and a total absence of disease pathology in leukotriene receptor-deficient mice [1].
  • Chinese hamster ovary cells expressing BLT2 exhibit LTB(4)-induced chemotaxis, calcium mobilization, and pertussis toxin-insensitive inhibition of adenylyl cyclase [2].
 

High impact information on Ltb4r2

  • BLT2 is expressed ubiquitously, in contrast to BLT1, which is expressed predominantly in leukocytes [2].
  • Several BLT1 antagonists, including U 75302, failed to inhibit LTB(4) binding to BLT2 [2].
  • BLT2 is highly homologous to BLT1, with an amino acid identity of 45.2%, and its open reading frame is located in the promoter region of the BLT1 gene [2].
  • Leukotriene B(4) mediates diverse inflammatory diseases through the G protein-coupled receptors BLT1 and BLT2 [1].
  • These data suggest the presence of functional BLT2 in primary keratinocytes [3].
 

Biological context of Ltb4r2

 

Anatomical context of Ltb4r2

  • Northern blot analysis showed that mouse BLT2 is expressed highly in small intestine and skin in contrast to the ubiquitous expression of human BLT2 [3].
  • Thus, BLT2 is a pharmacologically distinct receptor for LTB(4), and may mediate cellular functions in tissues other than leukocytes [2].
 

Analytical, diagnostic and therapeutic context of Ltb4r2

References

  1. Targeted Disruption of Leukotriene B4 Receptors BLT1 and BLT2: A Critical Role for BLT1 in Collagen-Induced Arthritis in Mice. Shao, W.H., Del Prete, A., Bock, C.B., Haribabu, B. J. Immunol. (2006) [Pubmed]
  2. A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., Shimizu, T. J. Exp. Med. (2000) [Pubmed]
  3. Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. Iizuka, Y., Yokomizo, T., Terawaki, K., Komine, M., Tamaki, K., Shimizu, T. J. Biol. Chem. (2005) [Pubmed]
  4. Leukotriene B4: metabolism and signal transduction. Yokomizo, T., Izumi, T., Shimizu, T. Arch. Biochem. Biophys. (2001) [Pubmed]
 
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