Gene Review:
NLRC4 - NLR family, CARD domain containing 4
Homo sapiens
Synonyms:
AIFEC, CARD, LRR, and NACHT-containing protein, CARD12, CLAN, CLAN1, ...
- A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. Mackey, Z.B., O'Brien, T.C., Greenbaum, D.C., Blank, R.B., McKerrow, J.H. J. Biol. Chem. (2004)
- Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. Poyet, J.L., Srinivasula, S.M., Tnani, M., Razmara, M., Fernandes-Alnemri, T., Alnemri, E.S. J. Biol. Chem. (2001)
- Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis. Sadasivam, S., Gupta, S., Radha, V., Batta, K., Kundu, T.K., Swarup, G. Oncogene (2005)
- Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. Geddes, B.J., Wang, L., Huang, W.J., Lavellee, M., Manji, G.A., Brown, M., Jurman, M., Cao, J., Morgenstern, J., Merriam, S., Glucksmann, M.A., DiStefano, P.S., Bertin, J. Biochem. Biophys. Res. Commun. (2001)
- Ipaf is upregulated by tumor necrosis factor-alpha in human leukemia cells. Gutierrez, O., Pipaon, C., Fernandez-Luna, J.L. FEBS Lett. (2004)
- Characteristics of traditional birth attendants and their beliefs and practices in the Offot Clan, Nigeria. Itina, S.M. Bull. World Health Organ. (1997)
- Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis. Thalappilly, S., Sadasivam, S., Radha, V., Swarup, G. FEBS J. (2006)
- Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthase. Romanyuk, N.D., Rigden, D.J., Vatamaniuk, O.K., Lang, A., Cahoon, R.E., Jez, J.M., Rea, P.A. Plant Physiol. (2006)