Gene Review:
APAF1 - apoptotic peptidase activating factor 1
Homo sapiens
Synonyms:
APAF-1, Apoptotic protease-activating factor 1, CED4, KIAA0413
Cain,
Papp,
Niemetz,
Dosdahl,
Kumar,
Schiffmann,
Zimmermann,
Bonzon,
Green,
Furukawa,
Nishimura,
Furukawa,
Satoh,
Endo,
Iwase,
Yamada,
Matsuda,
Kano,
Nakamura,
Chandra,
Bratton,
Person,
Tian,
Martin,
Ayres,
Fearnhead,
Gandhi,
Tang,
Christoph,
Weikert,
Kempkensteffen,
Krause,
Schostak,
Miller,
Schrader,
Sakamoto-Hojo,
Mello,
Pereira,
Fachin,
Cardoso,
Junta,
Sandrin-Garcia,
Donadi,
Passos,
Anichini,
Mortarini,
Sensi,
Zanon,
- Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance. Sun, Y., Orrenius, S., Pervaiz, S., Fadeel, B. Blood (2005)
- Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN. Teitz, T., Wei, T., Liu, D., Valentine, V., Valentine, M., Grenet, J., Lahti, J.M., Kidd, V.J. Oncogene (2002)
- D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1. Choi, S., Lew, K.L., Xiao, H., Herman-Antosiewicz, A., Xiao, D., Brown, C.K., Singh, S.V. Carcinogenesis (2007)
- Decreased expression of Apaf-1 with progression of melanoma. Mustika, R., Budiyanto, A., Nishigori, C., Ichihashi, M., Ueda, M. Pigment Cell Res. (2005)
- Apoptosome inactivation rescues proneural and neural cells from neurodegeneration. Cozzolino, M., Ferraro, E., Ferri, A., Rigamonti, D., Quondamatteo, F., Ding, H., Xu, Z.S., Ferrari, F., Angelini, D.F., Rotilio, G., Cattaneo, E., Carrì, M.T., Cecconi, F. Cell Death Differ. (2004)
- Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome. Chandra, D., Bratton, S.B., Person, M.D., Tian, Y., Martin, A.G., Ayres, M., Fearnhead, H.O., Gandhi, V., Tang, D.G. Cell (2006)
- Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Du, C., Fang, M., Li, Y., Li, L., Wang, X. Cell (2000)
- Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Zou, H., Henzel, W.J., Liu, X., Lutschg, A., Wang, X. Cell (1997)
- Inhibition of caspase-9 activity and Apaf-1 expression in cisplatin-resistant head and neck squamous cell carcinoma cells. Kuwahara, D., Tsutsumi, K., Oyake, D., Ohta, T., Nishikawa, H., Koizuka, I. Auris, nasus, larynx. (2003)
- Ca(2+)-induced inhibition of apoptosis in human SH-SY5Y neuroblastoma cells: degradation of apoptotic protease activating factor-1 (APAF-1). Reimertz, C., Kögel, D., Lankiewicz, S., Poppe, M., Prehn, J.H. J. Neurochem. (2001)
- Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Soengas, M.S., Capodieci, P., Polsky, D., Mora, J., Esteller, M., Opitz-Araya, X., McCombie, R., Herman, J.G., Gerald, W.L., Lazebnik, Y.A., Cordón-Cardó, C., Lowe, S.W. Nature (2001)
- Apaf-1/cytochrome c-independent and Smac-dependent induction of apoptosis in multiple myeloma (MM) cells. Chauhan, D., Hideshima, T., Rosen, S., Reed, J.C., Kharbanda, S., Anderson, K.C. J. Biol. Chem. (2001)
- Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain. Siniscalco, D., Fuccio, C., Giordano, C., Ferraraccio, F., Palazzo, E., Luongo, L., Rossi, F., Roth, K.A., Maione, S., de Novellis, V. Pharmacol. Res. (2007)
- A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathway. Vallender, E.J., Lahn, B.T. Hum. Mol. Genet. (2006)
- Gene expression profiles in human cells submitted to genotoxic stress. Sakamoto-Hojo, E.T., Mello, S.S., Pereira, E., Fachin, A.L., Cardoso, R.S., Junta, C.M., Sandrin-Garcia, P., Donadi, E.A., Passos, G.A. Mutat. Res. (2003)
- The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome C. Murphy, B.M., O'Neill, A.J., Adrain, C., Watson, R.W., Martin, S.J. J. Exp. Med. (2003)
- Apaf-1 is a mediator of E2F-1-induced apoptosis. Furukawa, Y., Nishimura, N., Furukawa, Y., Satoh, M., Endo, H., Iwase, S., Yamada, H., Matsuda, M., Kano, Y., Nakamura, M. J. Biol. Chem. (2002)
- Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. Saleh, A., Srinivasula, S.M., Acharya, S., Fishel, R., Alnemri, E.S. J. Biol. Chem. (1999)
- Requirement of cytochrome c for apoptosis in human cells. Matapurkar, A., Lazebnik, Y. Cell Death Differ. (2006)
- Chemical-induced apoptosis: formation of the Apaf-1 apoptosome. Cain, K. Drug Metab. Rev. (2003)
- Methylation silencing of the Apaf-1 gene in acute leukemia. Furukawa, Y., Sutheesophon, K., Wada, T., Nishimura, M., Saito, Y., Ishii, H., Furukawa, Y. Mol. Cancer Res. (2005)
- Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Beere, H.M., Wolf, B.B., Cain, K., Mosser, D.D., Mahboubi, A., Kuwana, T., Tailor, P., Morimoto, R.I., Cohen, G.M., Green, D.R. Nat. Cell Biol. (2000)
- The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mitchell, S.A., Spriggs, K.A., Coldwell, M.J., Jackson, R.J., Willis, A.E. Mol. Cell (2003)
- VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. Dias, S., Shmelkov, S.V., Lam, G., Rafii, S. Blood (2002)
- The machinery of programmed cell death. Zimmermann, K.C., Bonzon, C., Green, D.R. Pharmacol. Ther. (2001)
- APAF-1 signaling in human melanoma. Anichini, A., Mortarini, R., Sensi, M., Zanon, M. Cancer Lett. (2006)
- Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region. Adrain, C., Slee, E.A., Harte, M.T., Martin, S.J. J. Biol. Chem. (1999)
- Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Hu, Y., Benedict, M.A., Wu, D., Inohara, N., Núñez, G. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis. Ferrari, D., Stepczynska, A., Los, M., Wesselborg, S., Schulze-Osthoff, K. J. Exp. Med. (1998)
- Regularly methylated novel pro-apoptotic genes associated with recurrence in transitional cell carcinoma of the bladder. Christoph, F., Weikert, S., Kempkensteffen, C., Krause, H., Schostak, M., Miller, K., Schrader, M. Int. J. Cancer (2006)
- A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. Yu, X., Acehan, D., Ménétret, J.F., Booth, C.R., Ludtke, S.J., Riedl, S.J., Shi, Y., Wang, X., Akey, C.W. Structure (Camb.) (2005)
- Mutational analysis of Chk1, Chk2, Apaf1 and Rb1 in human malignant melanoma cell lines. Papp, T., Niemetz, A., Dosdahl, N., Kumar, K., Schiffmann, D. Oncol. Rep. (2007)
- Apaf-1 is a transcriptional target for E2F and p53. Moroni, M.C., Hickman, E.S., Lazzerini Denchi, E., Caprara, G., Colli, E., Cecconi, F., Müller, H., Helin, K. Nat. Cell Biol. (2001)
- Three new types of Apaf-1 in mammalian cells. Hahn, C., Hirsch, B., Jahnke, D., Dürkop, H., Stein, H. Biochem. Biophys. Res. Commun. (1999)
- Apaf-1 expression in human cutaneous melanoma progression and in pigmented nevi. Niedojadło, K., Łabedzka, K., Łada, E., Milewska, A., Chwirot, B.W. Pigment Cell Res. (2006)