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Gene Review

RPLP0  -  ribosomal protein, large, P0

Homo sapiens

Synonyms: 60S acidic ribosomal protein P0, 60S ribosomal protein L10E, L10E, LP0, P0, ...
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Disease relevance of RPLP0


High impact information on RPLP0

  • cDNA clones encoding three antigenically related human ribosomal phosphoproteins (P-proteins) P0, P1, and P2 were isolated and sequenced [4].
  • Unlike P1 and P2, P0 was not removable from ribosomes by an ethanol-NH4Cl washing procedure [5].
  • P2 along with its other family members, P0 and P1, constitutes a part of the elongation factor-binding site connected to the GTPase center in the 60S ribosomal subunit [6].
  • We have isolated and sequenced a 1308bp clone from a pupal brain cDNA library of the flesh fly, Sarcophaga crassipalpis, showing 97% amino acid (aa) sequence similarity to Ceratitis capitata 60S acidic ribosomal protein P0 (CcP0) and 93% aa sequence similiarity to Drosophila melanogaster P0 (DmP0) [7].
  • We discovered IgM antibodies to human P0 protein in the sera of 18.5% of the patients with GBS, 15.6% with CIDP, 6.4% with ONP and 3.8% of NC subjects [3].

Biological context of RPLP0

  • We have identified a new point mutation in the myelin protein zero (P0) gene in two genetically identical twins with a demyelinating neuropathy [8].
  • Therefore, in gene expression microarray experiments, genes whose expression is inhibited by subculture from passage 0 (P0) to passage 8 (P8) and enhanced by micropatterning and stretching were sought out [9].

Anatomical context of RPLP0

  • Immunisation with the peripheral nerve myelin proteins P0 or P2 induces inflammatory neuropathy in animals [3].
  • We serially investigated antigen-induced cytokine secretion from circulating T-cells stimulated with human peptides from the P0 and P2 proteins in seven patients and compared to results from seven serially investigated healthy controls [10].

Associations of RPLP0 with chemical compounds

  • A 35.5- to 36-kD acidic protein was released at low levels from ribosomes with 1.0 M NH4Cl/50% ethanol and identified as P0 [11].
  • In 1993 Hayasaka and colleagues found a point mutation in the myelin P0 gene (Asp 90 Glu) in this family, giving CMT1B a molecular basis [12].

Other interactions of RPLP0

  • The addition of PGK1 and RPLP0 increased the robustness in qRT-PCR applications not stratified by disease [13].
  • The housekeeping genes RPS9 and RPLP0 were applied to normalize differences in mRNA quality and quantity [14].
  • T helper type 2 like cytokine responses to peptides from P0 and P2 myelin proteins during the recovery phase of Guillain-Barré syndrome [10].

Analytical, diagnostic and therapeutic context of RPLP0

  • The P0 cDNA was initially identified by translation of hybrid-selected mRNA and immunoprecipitation of the products [4].


  1. Baculovirus-mediated expression and isolation of human ribosomal phosphoprotein P0 carrying a GST-tag in a functional state. Abo, Y., Hagiya, A., Naganuma, T., Tohkairin, Y., Shiomi, K., Kajiura, Z., Hachimori, A., Uchiumi, T., Nakagaki, M. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  2. Expression of P0- and P3-RNA from the normal and translocated c-myc allele in Burkitt's lymphoma cells. Eick, D., Polack, A., Kofler, E., Lenoir, G.M., Rickinson, A.B., Bornkamm, G.W. Oncogene (1990) [Pubmed]
  3. Antibody responses to P0 and P2 myelin proteins in Guillain-Barré syndrome and chronic idiopathic demyelinating polyradiculoneuropathy. Khalili-Shirazi, A., Atkinson, P., Gregson, N., Hughes, R.A. J. Neuroimmunol. (1993) [Pubmed]
  4. Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. Rich, B.E., Steitz, J.A. Mol. Cell. Biol. (1987) [Pubmed]
  5. Monoclonal antibodies against eucaryotic ribosomes. Use to characterize a ribosomal protein not previously identified and antigenically related to the acidic phosphoproteins P1/P2. Towbin, H., Ramjoué, H.P., Kuster, H., Liverani, D., Gordon, J. J. Biol. Chem. (1982) [Pubmed]
  6. Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. Freeman, J.L., Gonzalo, P., Pitcher, J.A., Claing, A., Lavergne, J.P., Reboud, J.P., Lefkowitz, R.J. Biochemistry (2002) [Pubmed]
  7. Sequence and transcription patterns of 60S ribosomal protein P0, a diapause-regulated AP endonuclease in the flesh fly, Sarcophaga crassipalpis. Craig, T.L., Denlinger, D.L. Gene (2000) [Pubmed]
  8. Phenotypic variation of a new P0 mutation in genetically identical twins. Marques, W., Hanna, M.G., Marques, S.R., Sweeney, M.G., Thomas, P.K., Wood, N.W. J. Neurol. (1999) [Pubmed]
  9. Biological responses of ligament fibroblasts and gene expression profiling on micropatterned silicone substrates subjected to mechanical stimuli. Park, S.A., Kim, I.A., Lee, Y.J., Shin, J.W., Kim, C.R., Kim, J.K., Yang, Y.I., Shin, J.W. J. Biosci. Bioeng. (2006) [Pubmed]
  10. T helper type 2 like cytokine responses to peptides from P0 and P2 myelin proteins during the recovery phase of Guillain-Barré syndrome. Dahle, C., Ekerfelt, C., Vrethem, M., Samuelsson, M., Ernerudh, J. J. Neurol. Sci. (1997) [Pubmed]
  11. Acidic phosphoprotein complex of the 60S ribosomal subunit of maize seedling roots. Components and changes in response to flooding. Bailey-Serres, J., Vangala, S., Szick, K., Lee, C.H. Plant Physiol. (1997) [Pubmed]
  12. Historical perspective of defining Charcot-Marie-Tooth type 1B. Bird, T.D. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  13. DNA and RNA references for qRT-PCR assays in exfoliated cervical cells. Steinau, M., Rajeevan, M.S., Unger, E.R. The Journal of molecular diagnostics : JMD. (2006) [Pubmed]
  14. RAR-beta(1) overexpression in chromophobe renal cell carcinoma: a novel target for therapeutic intervention? Goelden, U., Ukena, S.N., Pfoertner, S., Hofmann, R., Buer, J., Schrader, A.J. Experimental oncology. (2005) [Pubmed]
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