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Gene Review

SNORD95  -  small nucleolar RNA, C/D box 95

Homo sapiens

Synonyms: U95
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Disease relevance of SNORD95


High impact information on SNORD95

  • Two weeks following induction of senescence, clonal outgrowths were expanded and characterized in terms of senescence-associated beta-galactosidase activity, gene expression profiles (Affymetrix U95 probe sets, Affymetrix, Santa Clara, CA) with confirmatory Western analyses, and telomerase activity following a second drug treatment [2].
  • The region between -710 and +46 relative to the transcription start site of U95 was analyzed in this study [1].
  • These results demonstrate that R3 strongly enhances the U95 promoter activity and that NF-kappaB and binding sites for NF-kappaB in the R3 region play an important role in its activation [1].
  • Sequence analyses of U95 cDNA clones revealed that the transcription start site was located about 1.6 kbp upstream of the putative initiating ATG and that the transcript consisted of two exons [1].
  • To test this hypothesis, oligonucleotide probes for 12,000 genes arrayed on Affymetrix Human Genome U95 GeneChips were used for expression profiling of fluorescently labeled primary cRNAs from post-mortem cerebral cortex and cerebellum of a MD patient who died at 6 months of age and a normal control brain matched for age, gender, and race [3].

Biological context of SNORD95


Associations of SNORD95 with chemical compounds

  • The messenger ribonucleic acid (mRNA) from the samples was isolated, reverse transcribed, and used to generate biotin-labeled mRNA fragments, which were hybridized to Affymetrix U95 gene chips (AME Bioscience, Norway) for analysis [6].

Analytical, diagnostic and therapeutic context of SNORD95


  1. The R3 region, one of three major repetitive regions of human herpesvirus 6, is a strong enhancer of immediate-early gene U95. Takemoto, M., Shimamoto, T., Isegawa, Y., Yamanishi, K. J. Virol. (2001) [Pubmed]
  2. Evasion of a single-step, chemotherapy-induced senescence in breast cancer cells: implications for treatment response. Elmore, L.W., Di, X., Dumur, C., Holt, S.E., Gewirtz, D.A. Clin. Cancer Res. (2005) [Pubmed]
  3. Downregulation of myelination, energy, and translational genes in Menkes disease brain. Liu, P.C., Chen, Y.W., Centeno, J.A., Quezado, M., Lem, K., Kaler, S.G. Mol. Genet. Metab. (2005) [Pubmed]
  4. Gene expression profiles predict survival and progression of pleural mesothelioma. Pass, H.I., Liu, Z., Wali, A., Bueno, R., Land, S., Lott, D., Siddiq, F., Lonardo, F., Carbone, M., Draghici, S. Clin. Cancer Res. (2004) [Pubmed]
  5. A web-accessible complete transcriptome of normal human and DMD muscle. Bakay, M., Zhao, P., Chen, J., Hoffman, E.P. Neuromuscul. Disord. (2002) [Pubmed]
  6. Gene expression profiles in esophageal adenocarcinoma. Dahlberg, P.S., Ferrin, L.F., Grindle, S.M., Nelson, C.M., Hoang, C.D., Jacobson, B. Ann. Thorac. Surg. (2004) [Pubmed]
  7. Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations. Traynor, J., Agarwal, P., Lazzeroni, L., Francke, U. BMC Med. Genet. (2002) [Pubmed]
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