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Gene Review

PCGEM1  -  PCGEM1, prostate-specific transcript (non...

Homo sapiens

Synonyms: LINC00071, NCRNA00071, PCAT9
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Disease relevance of PCGEM1


High impact information on PCGEM1

  • Among various prostate cancer cell lines analyzed, PCGEM1 expression was detected only in the androgen receptor-positive cell line LNCaP [1].
  • Taken together, the remarkable prostate-tissue specificity and androgen-dependent expression of PCGEM1 as well as its elevated expression in a significant percentage of tumor tissues suggest specific functions of PCGEM1 in the biology and tumorigenesis of the prostate gland [1].
  • Extensive DNA sequence analysis of the PCGEM1 cDNA and genomic DNA revealed that PCGEM1 lacks protein-coding capacity and suggests that it may belong to an emerging class of noncoding RNAs, also called "riboregulators." The PCGEM1 locus was mapped to chromosome 2q32 [1].
  • Taken together, the cell proliferation/colony formation-promoting functions of PCGEM1 and the association of its increased expression with high-risk CaP patients suggest the potential roles of PCGEM1 in CaP onset/progression, especially in these high-risk groups [2].
  • PCGEM1 overexpression in LNCaP and in NIH3T3 cells promotes cell proliferation and a dramatic increase in colony formation, suggesting a biological role of PCGEM1 in cell growth regulation [2].

Biological context of PCGEM1

  • Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1 [3].
  • Upregulation of expression of human telomerase reverse transcriptase (hTERT), Survivin, DD3 and PCGEM1 mRNAs in PCa lesions has recently been described [4].

Anatomical context of PCGEM1


Associations of PCGEM1 with chemical compounds


Other interactions of PCGEM1


Analytical, diagnostic and therapeutic context of PCGEM1

  • Multiple tissue Northern blot analysis revealed that PCGEM1 was expressed exclusively in human prostate tissue [1].
  • Analysis of PCGEM1 expression in matched normal and primary tumor specimens revealed tumor-associated overexpression in 84% of patients with prostate cancer by in situ hybridization assay and in 56% of patients by reverse transcription-PCR assay [1].


  1. PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. Srikantan, V., Zou, Z., Petrovics, G., Xu, L., Augustus, M., Davis, L., Livezey, J.R., Connell, T., Sesterhenn, I.A., Yoshino, K., Buzard, G.S., Mostofi, F.K., McLeod, D.G., Moul, J.W., Srivastava, S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Petrovics, G., Zhang, W., Makarem, M., Street, J.P., Connelly, R., Sun, L., Sesterhenn, I.A., Srikantan, V., Moul, J.W., Srivastava, S. Oncogene (2004) [Pubmed]
  3. Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1. Fu, X., Ravindranath, L., Tran, N., Petrovics, G., Srivastava, S. DNA Cell Biol. (2006) [Pubmed]
  4. Expression of human telomerase reverse transcriptase, Survivin, DD3 and PCGEM1 messenger RNA in archival prostate carcinoma tissue. Bialkowska-Hobrzanska, H., Driman, D.K., Fletcher, R., Harry, V., Razvi, H. The Canadian journal of urology. (2006) [Pubmed]
  5. KLK31P is a novel androgen regulated and transcribed pseudogene of kallikreins that is expressed at lower levels in prostate cancer cells than in normal prostate cells. Lu, W., Zhou, D., Glusman, G., Utleg, A.G., White, J.T., Nelson, P.S., Vasicek, T.J., Hood, L., Lin, B. Prostate (2006) [Pubmed]
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