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Gene Review

ATG3  -  autophagy related 3

Homo sapiens

Synonyms: APG3, APG3-LIKE, APG3-like, APG3L, Autophagy-related protein 3, ...
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Disease relevance of ATG3


High impact information on ATG3


Biological context of ATG3

  • In the process of comparing the rat and human APG3L genes we showed that the organization of the human APG3L gene includes a unique transcriptional start site, a coding region with 12 translated exons and 11 introns and is located on human chromosome 3q13 [1].

Analytical, diagnostic and therapeutic context of ATG3


  1. The rat Apg3p/Aut1p homolog is upregulated by ischemic preconditioning in the retina. Wu, B.X., Darden, A.G., Laser, M., Li, Y., Crosson, C.E., Hazard, E.S., Ma, J.X. Mol. Vis. (2006) [Pubmed]
  2. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. Tanida, I., Tanida-Miyake, E., Komatsu, M., Ueno, T., Kominami, E. J. Biol. Chem. (2002) [Pubmed]
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