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Gene Review:

Mta1 - metastasis associated 1

Rattus norvegicus

Synonyms: Metastasis-associated protein MTA1, Zg29

Nicolson, G.L. et al., Moye, V.E. et al., Rösel, M. et al., Guo, W.J. et al., Kozlova, E.N. et al., et al.

Kozlova, Lukanidin, Guo, Li, Ling, Bai, Zhang, Cheng, Gu, Zhuang,

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Disease relevance of Mta1

Using subtractive technology, we have generated metastasis-associated gene expression profiles for rat mammary and pancreatic adenocarcinomas [1].
In view of the observed influence of C4.4A on metastasis formation and matrix penetration it is tempting to speculate that this newly described metastasis-associated molecule may exert functional activity similar to the uPAR, i.e. via activation of matrix degrading enzymes [2].
CONCLUSION: Blockage of hepatic arterial blood supply results in decreased blood perfusion and increased expression of metastasis-associated genes VEGF and MMP-1 of transplanted liver cancer in rats [3].

High impact information on Mta1

In addition, the expression of the mammary tumor metastasis-associated cell-surface glycoprotein gp580 on untransfected and transfected MTC.4 cells indicated that the cell populations of higher metastatic potential were also more diverse in their cell-to-cell antigen expression than untransfected or non-metastatic, transfected MTC.4 cells [4].
Metastasis-associated mts1 (S100A4) protein is selectively expressed in white matter astrocytes and is up-regulated after peripheral nerve or dorsal root injury [5].
A very close correlation is observed between the cell lines' metastatic potential in vivo and the osteopontin mRNA levels in vitro (R(2)=0.74), but not with another metastasis-associated protein in this system, S100A4 (R(2)=0.21) [6].
Stable transfection of Met-DNAs increases the level of the metastasis-associated protein, osteopontin [6].
Metastasis-associated mts1 (S100A4) protein in the developing and adult central nervous system [7].

References

Gene expression patterns associated with the metastatic phenotype in rodent and human tumors. Nestl, A., Von Stein, O.D., Zatloukal, K., Thies, W.G., Herrlich, P., Hofmann, M., Sleeman, J.P. Cancer Res. (2001) [Pubmed]
Cloning and functional characterization of a new phosphatidyl-inositol anchored molecule of a metastasizing rat pancreatic tumor. Rösel, M., Claas, C., Seiter, S., Herlevsen, M., Zöller, M. Oncogene (1998) [Pubmed]
Influence of hepatic arterial blockage on blood perfusion and VEGF, MMP-1 expression of implanted liver cancer in rats. Guo, W.J., Li, J., Ling, W.L., Bai, Y.R., Zhang, W.Z., Cheng, Y.F., Gu, W.H., Zhuang, J.Y. World J. Gastroenterol. (2002) [Pubmed]
Transfection of activated c-H-rasEJ/pSV2neo or pSV2neo genes into rat mammary cells: rapid stimulation of clonal diversification of spontaneous metastatic and cell-surface properties. Nicolson, G.L., Gallick, G.E., Spohn, W.H., Lembo, T.M., Tainsky, M.A. Oncogene (1992) [Pubmed]
Metastasis-associated mts1 (S100A4) protein is selectively expressed in white matter astrocytes and is up-regulated after peripheral nerve or dorsal root injury. Kozlova, E.N., Lukanidin, E. Glia (1999) [Pubmed]
Osteopontin expression correlates with adhesive and metastatic potential in metastasis-inducing DNA-transfected rat mammary cell lines. Moye, V.E., Barraclough, R., West, C., Rudland, P.S. Br. J. Cancer (2004) [Pubmed]
Metastasis-associated mts1 (S100A4) protein in the developing and adult central nervous system. Aberg, F., Kozlova, E.N. J. Comp. Neurol. (2000) [Pubmed]

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AgaP_AGAP004341	Anopheles gambiae str. PEST
MTA1	Canis lupus familiaris
mta1	Danio rerio
MTA1-like	Drosophila melanogaster
MTA1	Gallus gallus
MTA1	Homo sapiens
LOC710095	Macaca mulatta
Mta1	Mus musculus
MTA1	Pan troglodytes
mta1	Xenopus (Silurana) tropicalis

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