Disease relevance of Mta1

• Metastasis-associated protein S100A4 (Mts1) induces invasiveness of primary tumors and promotes metastasis [1].
• Our aim was to elucidate the impact of gain-of-function beta-catenin on the metastasis-associated gene S100A4 in human colon cancer cell lines and tumors [2].
• Metastasis-associated murine melanoma cell surface galactosyltransferase: characterization of enzyme activity and identification of the major surface substrates [3].
• c-erbB-2/neu overexpression enhances metastatic potential of human lung cancer cells by induction of metastasis-associated properties [4].
• Expression of Mts1, a metastasis-associated gene, increases motility but not invasion of a nonmetastatic mouse mammary adenocarcinoma cell line [5].

High impact information on Mta1

• Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis [6].
• A novel metastasis-associated gene was identified with a differential display system in murine carcinoma cells showing a high rate of metastasis to the liver [7].
• Together these data suggest that degradation of basement membrane proteins by metastatic melanoma cells may release fragments (such as LamA2091-2108) which stimulate both the production and activity of metastasis-associated proteinases such as t-PA, providing a mechanism for augmentation of the metastatic capacity of B16F10 melanoma cells [8].
• Finally, we show that HA fragment-induced MMP-9 transcription is mediated via NF-kappa B. Our results suggest that the metastasis-associated HA degradation in tumours might promote invasion by inducing MMP expression [9].
• Such a DNA-methylation-dependent AP-1 binding site was found in the first intron of the metastasis-associated mts1 gene [10].

Chemical compound and disease context of Mta1

• Recent studies have shown that an unpaired cysteine residue in the propeptide plays a key role in inactivation of latent metastasis-associated metalloproteinases: the present study was designed to assess whether NAC could also affect tumor take, invasion and metastasis of malignant cells [11].
• An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells [12].
• Expression of the transmembrane glycoprotein CD44 and metastasis associated 18A2/MTS1 gene in B16 murine melanoma cells [13].

Biological context of Mta1

• If Mta1 functions in cytoplasm, it might be involved in the regulation of endocytosis mediated by endophilin 3 [14].
• The full-length mouse Mta1 cDNA contained a 2145 nucleotide open reading frame encoding 715 amino acids [15].
• Knowledge of the Mta1 gene expression pattern will be useful in better understanding its functional diversity [15].
• Similar to the candidate metastasis associated protein MTA1, an elevated level of MTA2 correlates with cellular proliferation [16].
• Identification and characterization of the variants of metastasis-associated protein 1 generated following alternative splicing [15].

Anatomical context of Mta1

• To assess subcellular localization, green fluorescence protein (GFP)-tagged expression constructs of Mta1 and Mta3 and various deletion constructs of GFP-Mta1 were transiently expressed in Balb/MK keratinocytes [17].
• The Mta1 and endophilin 3 transcripts were highly expressed in testis and brain [14].
• The metastasis-associated gene 1 (mta1) was identified initially in rat highly metastatic cancer cell lines and found to be a component of the nucleosome remodeling and histone deacetylase (NuRD) complex [15].
• Metastasis-associated 5T4 oncofoetal antigen is concentrated at microvillus projections of the plasma membrane [18].
• The metastasis-associated metalloproteinase stromelysin-3 is induced by transforming growth factor-beta in osteoblasts and fibroblasts [19].

Associations of Mta1 with chemical compounds

• The synthetic laminin pentapeptide tyrosyl-isoleucyl-glycyl-seryl-arginine (YIGSR) binds to a metastasis associated high-affinity laminin receptor [20].
• We previously showed that the expression of the dominant metastasis associated gene mts1 was up-regulated by MSH but down-regulated by verapamil [21].

Regulatory relationships of Mta1

• Gene transfer of the vascular endothelial growth factor receptor flt-1 suppresses pulmonary metastasis associated with lung growth [22].

Other interactions of Mta1

• The site of interaction was suggested to be the SH-3-binding domain of Mta1 and SH-3 domain of endophilin 3 [14].
• We characterized the mouse metastasis-associated gene 2 product (mmta2), which is a homolog of the metastasis-associated gene 1 product (MTA1) [23].
• We showed that the presence of high AP-1 activity was not sufficient for the induction of invasion- and metastasis-associated AP-1-dependent genes in transformed bone cells [24].
• Interaction of metastasis associated Mts1 protein with nonmuscle myosin [25].
• Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7 alter the expression of metastasis-associated genes MTS1 and NM23 in metastatic variants of the B16 murine melanoma [26].

Analytical, diagnostic and therapeutic context of Mta1

• In this study, the interaction between laminin and the high affinity metastasis-associated 67 kD laminin receptor (67 LR) was investigated by electron microscopy using the rotary shadowing technique [27].
• Identify lymphatic metastasis-associated genes in mouse hepatocarcinoma cell lines using gene chip [28].

References