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Gene Review

Mmp1  -  matrix metalloproteinase 1

Rattus norvegicus

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Disease relevance of Mmp1


Psychiatry related information on Mmp1

  • The periovulatory increase in ovarian matrix metalloproteinase inhibitor (MMPI) expression is regulated both in vitro and in vivo by LH, but the intermediary steps in this process are uncertain [6].

High impact information on Mmp1


Chemical compound and disease context of Mmp1


Biological context of Mmp1


Anatomical context of Mmp1


Associations of Mmp1 with chemical compounds


Physical interactions of Mmp1


Regulatory relationships of Mmp1


Other interactions of Mmp1


Analytical, diagnostic and therapeutic context of Mmp1


  1. Experimental colonic obstruction increases collagen degradation by matrix metalloproteinases in the bowel wall. Syk, I., Mirastschijski, U., Jeppsson, B.W., Agren, M.S. Dis. Colon Rectum (2003) [Pubmed]
  2. Suppression of prostate cancer invasive potential and matrix metalloproteinase activity by E-cadherin transfection. Luo, J., Lubaroff, D.M., Hendrix, M.J. Cancer Res. (1999) [Pubmed]
  3. Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat. Boixel, C., Fontaine, V., Rücker-Martin, C., Milliez, P., Louedec, L., Michel, J.B., Jacob, M.P., Hatem, S.N. J. Am. Coll. Cardiol. (2003) [Pubmed]
  4. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Romanic, A.M., White, R.F., Arleth, A.J., Ohlstein, E.H., Barone, F.C. Stroke (1998) [Pubmed]
  5. Influence of therapeutic hypothermia on matrix metalloproteinase activity after traumatic brain injury in rats. Truettner, J.S., Alonso, O.F., Dalton Dietrich, W. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  6. Divergent effects of interleukin-1 beta on steroidogenesis and matrix metalloproteinase inhibitor expression and activity in cultured rat granulosa cells. Nothnick, W.B., Curry, T.E. Endocrinology (1996) [Pubmed]
  7. Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease. Cowan, K.N., Jones, P.L., Rabinovitch, M. J. Clin. Invest. (2000) [Pubmed]
  8. A program of cell death and extracellular matrix degradation is activated in the amnion before the onset of labor. Lei, H., Furth, E.E., Kalluri, R., Chiou, T., Tilly, K.I., Tilly, J.L., Elkon, K.B., Jeffrey, J.J., Strauss, J.F. J. Clin. Invest. (1996) [Pubmed]
  9. Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking. Issa, R., Zhou, X., Constandinou, C.M., Fallowfield, J., Millward-Sadler, H., Gaca, M.D., Sands, E., Suliman, I., Trim, N., Knorr, A., Arthur, M.J., Benyon, R.C., Iredale, J.P. Gastroenterology (2004) [Pubmed]
  10. Rat hepatic lipocytes synthesize and secrete transin (stromelysin) in early primary culture. Vyas, S.K., Leyland, H., Gentry, J., Arthur, M.J. Gastroenterology (1995) [Pubmed]
  11. Stimulation of interstitial collagenase in co-cultures of rat hepatocytes and sinusoidal cells. Kashiwazaki, K., Hibbs, M.S., Seyer, J.M., Mainardi, C.L., Kang, A.H. Gastroenterology (1986) [Pubmed]
  12. Estrogen modulation of left ventricular remodeling in the aged heart. Xu, Y., Arenas, I.A., Armstrong, S.J., Davidge, S.T. Cardiovasc. Res. (2003) [Pubmed]
  13. Effect of ramipril and furosemide treatment on interstitial remodeling in post-infarction heart failure rat hearts. Seeland, U., Kouchi, I., Zolk, O., Itter, G., Linz, W., Böhm, M. J. Mol. Cell. Cardiol. (2002) [Pubmed]
  14. L-arginine attenuates acute pulmonary embolism-induced increases in lung matrix metalloproteinase-2 and matrix metalloproteinase-9. Souza-Costa, D.C., Zerbini, T., Palei, A.C., Gerlach, R.F., Tanus-Santos, J.E. Chest (2005) [Pubmed]
  15. Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines. Ramamurthy, N.S., Rifkin, B.R., Greenwald, R.A., Xu, J.W., Liu, Y., Turner, G., Golub, L.M., Vernillo, A.T. J. Periodontol. (2002) [Pubmed]
  16. Preventive versus treatment effect of AG3340, a potent matrix metalloproteinase inhibitor in a rat model of choroidal neovascularization. El Bradey, M., Cheng, L., Bartsch, D.U., Appelt, K., Rodanant, N., Bergeron-Lynn, G., Freeman, W.R. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2004) [Pubmed]
  17. Divergent patterns of matrix metalloproteinase activity during wound healing in ileum and colon of rats. Seifert, W.F., Wobbes, T., Hendriks, T. Gut (1996) [Pubmed]
  18. Effect of amplitude and frequency of cyclic tensile strain on the inhibition of MMP-1 mRNA expression in tendon cells: an in vitro study. Lavagnino, M., Arnoczky, S.P., Tian, T., Vaupel, Z. Connect. Tissue Res. (2003) [Pubmed]
  19. Expression of matrix metalloproteinases during rat skin wound healing: evidence that membrane type-1 matrix metalloproteinase is a stromal activator of pro-gelatinase A. Okada, A., Tomasetto, C., Lutz, Y., Bellocq, J.P., Rio, M.C., Basset, P. J. Cell Biol. (1997) [Pubmed]
  20. TGF-beta plays a key role in morphogenesis of the pancreatic islets of Langerhans by controlling the activity of the matrix metalloproteinase MMP-2. Miralles, F., Battelino, T., Czernichow, P., Scharfmann, R. J. Cell Biol. (1998) [Pubmed]
  21. Inhibition of matrix metalloproteinase activity inhibits smooth muscle cell migration but not neointimal thickening after arterial injury. Bendeck, M.P., Irvin, C., Reidy, M.A. Circ. Res. (1996) [Pubmed]
  22. Expression and activation of matrix metalloproteinases in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. Siméon, A., Monier, F., Emonard, H., Gillery, P., Birembaut, P., Hornebeck, W., Maquart, F.X. J. Invest. Dermatol. (1999) [Pubmed]
  23. Myocardial collagenase: purification and structural characterization. Tyagi, S.C., Cleutjens, J.P. The Canadian journal of cardiology. (1996) [Pubmed]
  24. Expression of matrix metalloproteinase genes in transformed rat cell lines of high and low metastatic potential. Sreenath, T., Matrisian, L.M., Stetler-Stevenson, W., Gattoni-Celli, S., Pozzatti, R.O. Cancer Res. (1992) [Pubmed]
  25. Rapid release of matrix metalloproteinase (MMP)-2 by thrombin in the rat aorta: modulation by protein tyrosine kinase/phosphatase. Fernandez-Patron, C., Zhang, Y., Radomski, M.W., Hollenberg, M.D., Davidge, S.T. Thromb. Haemost. (1999) [Pubmed]
  26. Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats. Wang, M., Zhang, J., Spinetti, G., Jiang, L.Q., Monticone, R., Zhao, D., Cheng, L., Krawczyk, M., Talan, M., Pintus, G., Lakatta, E.G. Am. J. Pathol. (2005) [Pubmed]
  27. Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium. Harkness, K.A., Adamson, P., Sussman, J.D., Davies-Jones, G.A., Greenwood, J., Woodroofe, M.N. Brain (2000) [Pubmed]
  28. Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN: attenuation by the synthetic matrix metalloproteinase inhibitor, Prinomastat (AG3340). Foda, H.D., Rollo, E.E., Drews, M., Conner, C., Appelt, K., Shalinsky, D.R., Zucker, S. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  29. Aluminum chloride pretreatment of elastin inhibits elastolysis by matrix metalloproteinases and leads to inhibition of elastin-oriented calcification. Bailey, M., Xiao, H., Ogle, M., Vyavahare, N. Am. J. Pathol. (2001) [Pubmed]
  30. Gonadotropin-releasing hormone agonist has the ability to induce increased matrix metalloproteinase (MMP)-2 and membrane type 1-MMP expression in corpora lutea, and structural luteolysis in rats. Goto, T., Endo, T., Henmi, H., Kitajima, Y., Kiya, T., Nishikawa, A., Manase, K., Sato, H., Kudo, R. J. Endocrinol. (1999) [Pubmed]
  31. LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation. Li, D., Williams, V., Liu, L., Chen, H., Sawamura, T., Antakli, T., Mehta, J.L. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  32. Insulin-like growth factors inhibit interstitial collagenase synthesis in bone cell cultures. Canalis, E., Rydziel, S., Delany, A.M., Varghese, S., Jeffrey, J.J. Endocrinology (1995) [Pubmed]
  33. Basic fibroblast growth factor stimulates expression of interstitial collagenase and inhibitors of metalloproteinases in rat bone cells. Varghese, S., Ramsby, M.L., Jeffrey, J.J., Canalis, E. Endocrinology (1995) [Pubmed]
  34. Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. Cheng, S., Lovett, D.H. Am. J. Pathol. (2003) [Pubmed]
  35. Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB. Popov, Y., Patsenker, E., Bauer, M., Niedobitek, E., Schulze-Krebs, A., Schuppan, D. J. Biol. Chem. (2006) [Pubmed]
  36. Differential regulation of glomerular gelatinase B (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in obese Zucker rats. Schaefer, L., Han, X., August, C., Matzkies, F., Lorenz, T., Schaefer, R.M. Diabetologia (1997) [Pubmed]
  37. Decreased matrix degradation in diabetic nephropathy: effects of ACE inhibition on the expression and activities of matrix metalloproteinases. McLennan, S.V., Kelly, D.J., Cox, A.J., Cao, Z., Lyons, J.G., Yue, D.K., Gilbert, R.E. Diabetologia (2002) [Pubmed]
  38. Matrix metalloproteinase induction by EMMPRIN in experimental focal cerebral ischemia. Burggraf, D., Liebetrau, M., Martens, H.K., Wunderlich, N., Jäger, G., Dichgans, M., Hamann, G.F. Eur. J. Neurosci. (2005) [Pubmed]
  39. Expression of matrix metalloproteinase genes in the rat intramembranous bone during postnatal growth and upon mechanical stresses. Collins, J.M., Ramamoorthy, K., Da Silveira, A., Patston, P., Mao, J.J. Journal of biomechanics. (2005) [Pubmed]
  40. Time-dependent inhibition of immune complex-induced lung injury by catalase: relationship to alterations in macrophage and neutrophil matrix metalloproteinase elaboration. Warner, R.L., Bless, N.M., Lewis, C.S., Younkin, E., Beltran, L., Guo, R., Johnson, K.J., Varani, J. Free Radic. Biol. Med. (2000) [Pubmed]
  41. Evidence for recipient derived fibroblast recruitment and activation during the development of chronic cardiac allograft rejection. Wu, G.D., Tuan, T.L., Bowdish, M.E., Jin, Y.S., Starnes, V.A., Cramer, D.V., Barr, M.L. Transplantation (2003) [Pubmed]
  42. Regulation of collagen degradation in the rat myocardium after infarction. Cleutjens, J.P., Kandala, J.C., Guarda, E., Guntaka, R.V., Weber, K.T. J. Mol. Cell. Cardiol. (1995) [Pubmed]
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