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Gene Review

ANAPC1  -  anaphase promoting complex subunit 1

Homo sapiens

Synonyms: APC1, Anaphase-promoting complex subunit 1, Cyclosome subunit 1, MCPR, Mitotic checkpoint regulator, ...
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High impact information on ANAPC1

  • We also show that overexpression of TAF72 or TAF73 suppresses the cell cycle arrest in mitosis caused by a mutation in the anaphase-promoting complex/cyclosome subunit gene cut9(+) [1].
  • A rcaD mutant generated by allelic exchange exhibited altered expression of the cpc2, cpeBA, apc1 and cpc1 operons upon green to red-light shifts [2].
  • We found that the nucleocytoplasmic shuttling activity is critical for efficient APC1 association and induction of apoptosis in transformed cells [3].
  • We have also investigated the RNA and protein expression of the Apc1 and other APC/C components in normal and cancer cells and the relative occurrence of expressed sequence tags (ESTs) representing APC subunits from different tissues [4].
  • Cut4 (Apc1), the largest subunit, plays an essential role in the assembly and functional regulation of the cyclosome in response to cell cycle arrest and stresses [5].

Biological context of ANAPC1

  • Associated with a europium trisbipyridine cryptate as donor, crosslinked APC1 was compared with crosslinked APC as acceptor in homogeneous time resolved fluorescence technology based on a fluorescence resonance energy transfer process [6].
  • High-avidity rabbit polyclonal antibodies were produced against synthetic peptides corresponding to amino acids 1865-1881 (APC-1) and to amino acids 1336-1350 (APC-2) in APC's 2844 amino acid sequence [7].
  • Macrophages (M phi) as well as dendritic cells (DCs) can undergo Th1- or Th2-like polarization; APC1 and APC2 thus acquire the capacity to drive the development of naive T cells and the reactivation of resting T cells towards either a Th1 or a Th2 phenotype, respectively [8].

Anatomical context of ANAPC1

  • In vitro experiments with monocyte-derived dendritic cells (DC) showed that the presence of IFN-gamma during activation of immature DC primes for mature DC with the ability of high IL-12 production and, consequently, a Th1-driving capacity (APC1 or DC1) [9].

Associations of ANAPC1 with chemical compounds


Regulatory relationships of ANAPC1


Analytical, diagnostic and therapeutic context of ANAPC1


  1. Two WD repeat-containing TATA-binding protein-associated factors in fission yeast that suppress defects in the anaphase-promoting complex. Mitsuzawa, H., Seino, H., Yamao, F., Ishihama, A. J. Biol. Chem. (2001) [Pubmed]
  2. Co-ordinated expression of phycobiliprotein operons in the chromatically adapting cyanobacterium Calothrix PCC 7601: a role for RcaD and RcaG. Noubir, S., Luque, I., Ochoa de Alda, J.A., Perewoska, I., Tandeau de Marsac, N., Cobley, J.G., Houmard, J. Mol. Microbiol. (2002) [Pubmed]
  3. Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies. Heilman, D.W., Teodoro, J.G., Green, M.R. J. Virol. (2006) [Pubmed]
  4. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. Jörgensen, P.M., Gräslund, S., Betz, R., Ståhl, S., Larsson, C., Höög, C. Gene (2001) [Pubmed]
  5. Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization. Yanagida, M., Yamashita, Y.M., Tatebe, H., Ishii, K., Kumada, K., Nakaseko, Y. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1999) [Pubmed]
  6. Allophycocyanin 1 as a near-infrared fluorescent tracer: isolation, characterization, chemical modification, and use in a homogeneous fluorescence resonance energy transfer system. Trinquet, E., Maurin, F., Préaudat, M., Mathis, G. Anal. Biochem. (2001) [Pubmed]
  7. Radioimmunoassay of the APC gene product using antibodies against its middle and carboxyl regions. Boman, B.M., Lovas, S., Abraham, C., Adrian, T.E., Murphy, R.F., Marbello, R., Bhattacharya, G. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  8. Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing. Gratchev, A., Schledzewski, K., Guillot, P., Goerdt, S. Skin Pharmacol. Appl. Skin Physiol. (2001) [Pubmed]
  9. The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy. Kapsenberg, M.L., Hilkens, C.M., Wierenga, E.A., Kalinski, P. Clin. Exp. Allergy (1999) [Pubmed]
  10. The destruction box of the cyclin Clb2 binds the anaphase-promoting complex/cyclosome subunit Cdc23. Meyn, M.A., Melloy, P.G., Li, J., Holloway, S.L. Arch. Biochem. Biophys. (2002) [Pubmed]
  11. Molecular cloning of prohormone convertase 1 from the atrial gland of Aplysia. Gorham, E.L., Nagle, G.T., Smith, J.S., Shen, H., Kurosky, A. DNA Cell Biol. (1996) [Pubmed]
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