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Gene Review:

Spag6 - sperm associated antigen 6

Mus musculus

Synonyms: Axoneme central apparatus protein, PF16, Pf16, Protein PF16 homolog, Sperm-associated antigen 6

Sapiro, R. et al., Zhang, Z. et al., Sapiro, R. et al.

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Disease relevance of Spag6

Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6 [1].

High impact information on Spag6

Immunocytochemistry localized Pf20 to the tails of permeabilized sperm; electron microscope immunocytochemistry showed that Pf20 was located in the axoneme central apparatus [2].
The Spag6 gene was found to be highly expressed in testis and was mapped using the T31 radiation hybrid panel to mouse chromosome 16 [3].
An antipeptide antibody generated against a C-terminal sequence recognized a 55-kDa protein in sperm extracts and localized Spag6 to the principal piece of permeabilized mouse sperm tails [3].
When expressed in COS-1 cells, Spag6 colocalized with microtubules [3].

Biological context of Spag6

A cDNA encoding sperm antigen 6 (Spag6), the murine homologue of the Chlamydomonas reinhardtii PF16 protein-a component of the flagella central apparatus-was isolated from a mouse testis cDNA library [3].

Analytical, diagnostic and therapeutic context of Spag6

Yeast two-hybrid assays demonstrated interaction of the Pf20 WD repeats with Spag6 [2].

References

Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6. Sapiro, R., Kostetskii, I., Olds-Clarke, P., Gerton, G.L., Radice, G.L., Strauss III, J.F. Mol. Cell. Biol. (2002) [Pubmed]
A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16. Zhang, Z., Sapiro, R., Kapfhamer, D., Bucan, M., Bray, J., Chennathukuzhi, V., McNamara, P., Curtis, A., Zhang, M., Blanchette-Mackie, E.J., Strauss, J.F. Mol. Cell. Biol. (2002) [Pubmed]
Sperm antigen 6 is the murine homologue of the Chlamydomonas reinhardtii central apparatus protein encoded by the PF16 locus. Sapiro, R., Tarantino, L.M., Velazquez, F., Kiriakidou, M., Hecht, N.B., Bucan, M., Strauss, J.F. Biol. Reprod. (2000) [Pubmed]

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