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Gene Review

Spag6  -  sperm associated antigen 6

Mus musculus

Synonyms: Axoneme central apparatus protein, PF16, Pf16, Protein PF16 homolog, Sperm-associated antigen 6
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Disease relevance of Spag6


High impact information on Spag6


Biological context of Spag6


Analytical, diagnostic and therapeutic context of Spag6


  1. Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6. Sapiro, R., Kostetskii, I., Olds-Clarke, P., Gerton, G.L., Radice, G.L., Strauss III, J.F. Mol. Cell. Biol. (2002) [Pubmed]
  2. A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16. Zhang, Z., Sapiro, R., Kapfhamer, D., Bucan, M., Bray, J., Chennathukuzhi, V., McNamara, P., Curtis, A., Zhang, M., Blanchette-Mackie, E.J., Strauss, J.F. Mol. Cell. Biol. (2002) [Pubmed]
  3. Sperm antigen 6 is the murine homologue of the Chlamydomonas reinhardtii central apparatus protein encoded by the PF16 locus. Sapiro, R., Tarantino, L.M., Velazquez, F., Kiriakidou, M., Hecht, N.B., Bucan, M., Strauss, J.F. Biol. Reprod. (2000) [Pubmed]
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