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Gene Review

SPTBN1  -  spectrin, beta, non-erythrocytic 1

Homo sapiens

Synonyms: Beta-II spectrin, ELF, Fodrin beta chain, HEL102, SPTB2, ...
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Disease relevance of SPTBN1


High impact information on SPTBN1


Biological context of SPTBN1


Anatomical context of SPTBN1

  • As a first step to understanding this interaction, kinetic and equilibrium assays have been used to monitor which regions of beta I and beta II spectrin inhibit the binding of purified 125I-labeled bovine brain spectrin to demyelinated and NaOH-stripped bovine brain membranes [7].
  • In rat heart and skeletal muscle, both long and short C-terminal forms of betaII spectrin localized in the region of the Z line [4].
  • We postulate that in concert with calpain, caspase rapidly targets critical sites in both alphaII- and betaII-spectrin and thereby initiates a rapid dissolution of the spectrin-actin cortical cytoskeleton with apoptosis [2].

Associations of SPTBN1 with chemical compounds


Other interactions of SPTBN1


  1. Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin. Scoles, D.R., Huynh, D.P., Morcos, P.A., Coulsell, E.R., Robinson, N.G., Tamanoi, F., Pulst, S.M. Nat. Genet. (1998) [Pubmed]
  2. Simultaneous degradation of alphaII- and betaII-spectrin by caspase 3 (CPP32) in apoptotic cells. Wang, K.K., Posmantur, R., Nath, R., McGinnis, K., Whitton, M., Talanian, R.V., Glantz, S.B., Morrow, J.S. J. Biol. Chem. (1998) [Pubmed]
  3. Phosphorylation of a Threonine Unique to the Short C-terminal Isoform of betaII-Spectrin Links Regulation of {alpha}-beta Spectrin Interaction to Neuritogenesis. Bignone, P.A., King, M.D., Pinder, J.C., Baines, A.J. J. Biol. Chem. (2007) [Pubmed]
  4. Identification of a novel C-terminal variant of beta II spectrin: two isoforms of beta II spectrin have distinct intracellular locations and activities. Hayes, N.V., Scott, C., Heerkens, E., Ohanian, V., Maggs, A.M., Pinder, J.C., Kordeli, E., Baines, A.J. J. Cell. Sci. (2000) [Pubmed]
  5. Effects of Nf2 missense mutations on schwannomin interactions. Scoles, D.R., Chen, M., Pulst, S.M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  6. Characterization of NF-L and betaIISigma1-spectrin interaction in live cells. Macioce, P., Gandolfi, N., Leung, C.L., Chin, S.S., Malchiodi-Albedi, F., Ceccarini, M., Petrucci, T.C., Liem, R.K. Exp. Cell Res. (1999) [Pubmed]
  7. Beta II-spectrin (fodrin) and beta I epsilon 2-spectrin (muscle) contain NH2- and COOH-terminal membrane association domains (MAD1 and MAD2). Lombardo, C.R., Weed, S.A., Kennedy, S.P., Forget, B.G., Morrow, J.S. J. Biol. Chem. (1994) [Pubmed]
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