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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hdhd1a  -  haloacid dehalogenase-like hydrolase...

Mus musculus

Synonyms: 1700121L12Rik, 5'-PsiMPase, GS1, Haloacid dehalogenase-like hydrolase domain-containing protein 1, Haloacid dehalogenase-like hydrolase domain-containing protein 1A, ...
 
 
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High impact information on Hdhd1a

  • This kinase activity was heparin-sensitive and also measurable with the G peptide (SPQPSRRGSESSEE) and GS-1 peptide (YRRAAVPPSPSPSLSRHSSPHQSEDEE), which contain consensus sequences for phosphorylation by CK-2 [1].
  • We suggest that the carbohydrate receptors for GS-1 and PWM are consistent markers for the presence of the myoepithelial cell in normal and tumorous rat mammary glands [2].
  • The histochemical binding of GS-1 and PWM to myoepithelial cells is inhibited specifically by D-galactose and by polymers of N-acetylglucosamine, respectively [2].
  • At the ultrastructural level, both conjugated GS-1 and PWM bind to the plasma membrane of the myoepithelial cells, as well as to the adjacent basement membrane [2].
  • Differential screening of a murine RNA-based lambda gt10 cDNA library with cell cycle phase-specific probes released a cDNA clone (lambda GS1) to a mRNA (1.8 kb) which is prevalent in the S phase of the cell cycle [3].
 

Associations of Hdhd1a with chemical compounds

  • Peroxidase-conjugated Griffonia simplicifolia-1 (GS-1) and pokeweed mitogen (PWM) histochemically stain only the myoepithelial cells and not the epithelial or fibroblastic cells of rat mammary glands preserved in methacarn or glutaraldehyde and embedded in paraffin [2].

References

  1. Rapid stimulation of Ser/Thr protein kinases following treatment of Swiss 3T3 cells with bombesin. Involvement of casein kinase-2 in the signaling pathway of bombesin. Agostinis, P., Van Lint, J., Sarno, S., De Witte, P., Vandenheede, J.R., Merlevede, W. J. Biol. Chem. (1992) [Pubmed]
  2. Immunocytochemical identification of myoepithelial cells in normal and neoplastic rat mammary glands with the lectins Griffonia simplicifolia-1 and pokeweed mitogen. Hughes, C.M., Rudland, P.S. J. Histochem. Cytochem. (1990) [Pubmed]
  3. Sequence of a complete murine cDNA reflecting an S phase-prevalent transcript encoding a protein with two types of nucleic acid binding motifs. Schmidt, G., Werner, D. Biochim. Biophys. Acta (1993) [Pubmed]
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