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Gene Review

Hdhd1a  -  haloacid dehalogenase-like hydrolase...

Mus musculus

Synonyms: 1700121L12Rik, 5'-PsiMPase, GS1, Haloacid dehalogenase-like hydrolase domain-containing protein 1, Haloacid dehalogenase-like hydrolase domain-containing protein 1A, ...
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High impact information on Hdhd1a

  • This kinase activity was heparin-sensitive and also measurable with the G peptide (SPQPSRRGSESSEE) and GS-1 peptide (YRRAAVPPSPSPSLSRHSSPHQSEDEE), which contain consensus sequences for phosphorylation by CK-2 [1].
  • We suggest that the carbohydrate receptors for GS-1 and PWM are consistent markers for the presence of the myoepithelial cell in normal and tumorous rat mammary glands [2].
  • The histochemical binding of GS-1 and PWM to myoepithelial cells is inhibited specifically by D-galactose and by polymers of N-acetylglucosamine, respectively [2].
  • At the ultrastructural level, both conjugated GS-1 and PWM bind to the plasma membrane of the myoepithelial cells, as well as to the adjacent basement membrane [2].
  • Differential screening of a murine RNA-based lambda gt10 cDNA library with cell cycle phase-specific probes released a cDNA clone (lambda GS1) to a mRNA (1.8 kb) which is prevalent in the S phase of the cell cycle [3].

Associations of Hdhd1a with chemical compounds

  • Peroxidase-conjugated Griffonia simplicifolia-1 (GS-1) and pokeweed mitogen (PWM) histochemically stain only the myoepithelial cells and not the epithelial or fibroblastic cells of rat mammary glands preserved in methacarn or glutaraldehyde and embedded in paraffin [2].


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