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Gene Review

BRDT  -  bromodomain, testis-specific

Homo sapiens

Synonyms: BRD6, Bromodomain testis-specific protein, CT9, Cancer/testis antigen 9, RING3-like protein
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Disease relevance of BRDT


High impact information on BRDT

  • BRDT specifically binds hyperacetylated histone H4 tail depending on the integrity of both bromodomains [3].
  • Moreover, in somatic cells, the ectopic expression of BRDT triggered a dramatic reorganization of the chromatin only after induction of histone hyperacetylation by trichostatin A (TSA) [3].
  • Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein [3].
  • The gene has been named BRDT (for bromodomain, testis specific) [4].
  • In contrast, when expression of RET finger protein (RFP) and bromodomain testis-specific (BRDT) genes, which are also known to be highly expressed in the testis, was examined, no significant difference in their expression levels was observed between squamous cell carcinomas and adenocarcinomas [5].

Analytical, diagnostic and therapeutic context of BRDT


  1. Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9. Scanlan, M.J., Altorki, N.K., Gure, A.O., Williamson, B., Jungbluth, A., Chen, Y.T., Old, L.J. Cancer Lett. (2000) [Pubmed]
  2. Bipolar radiofrequency dissection tonsillectomy: a prospective randomized trial. Ragab, S.M. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (2005) [Pubmed]
  3. Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein. Pivot-Pajot, C., Caron, C., Govin, J., Vion, A., Rousseaux, S., Khochbin, S. Mol. Cell. Biol. (2003) [Pubmed]
  4. Identification and characterization of BRDT: A testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh. Jones, M.H., Numata, M., Shimane, M. Genomics (1997) [Pubmed]
  5. CD109 expression in squamous cell carcinoma of the uterine cervix. Zhang, J.M., Hashimoto, M., Kawai, K., Murakumo, Y., Sato, T., Ichihara, M., Nakamura, S., Takahashi, M. Pathol. Int. (2005) [Pubmed]
  6. Molecular cloning and expression of a novel alternative splice variant of BRDT gene. Zheng, Y., Yuan, W., Zhou, Z., Xu, M., Sha, J.H. Int. J. Mol. Med. (2005) [Pubmed]
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