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Gene Review

ST8  -  suppression of tumorigenicity 8 (ovarian)

Homo sapiens

Synonyms: OVC, OVCS
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High impact information on ST8

  • The MRSA strains that were sequence type 8 (ST8), staphylococcal cassette chromosome mec (SCCmec) type IV, and Panton-Valentine leukocidin-positive clustered separately from those that were ST5 and SCCmec type II [1].
  • The overwhelming majority of the isolates-187 of 202, or 93%-belonged to one of three internationally spread epidemic clones which were identified on the basis of their multilocus sequence type (ST) as E-MRSA-16 (ST36), the New York clone V (ST8), and the New York/Japan clone (ST5; SCCmec II) and its single- and double-locus variants [2].
  • The detection limit observed for ST8 purified from K562 cells was approximately 2 pg by dot-blot analysis [3].
  • This paper reports the development of a synthetic probe composed of oxidized colominic acid coupled to biotinyl-L-lysine hydrazide to detect and quantify ST8 with putative "initiase" activity and its use in three solid-phase applications [3].
  • PCRs for cataloguing the staphylococcal cassette chromosome (SCCmec) type were negative for two of these, suggesting the existence of a new methicillin-resistance gene complex in the ST8 genetic background [4].

Biological context of ST8

  • The most common PVL-MRSA genotypes were sequence type ST8, ST22, ST30, ST59 and ST80 [5].
  • The results showed that serogroup C meningococci were predominant, and that a dramatic increase in the circulation of strains with decreased susceptibility to penicillin was associated mainly with a prevalent phenotype C:2b:P1.5,2, which belongs to the hyper-virulent ST8/A4 cluster [6].

Other interactions of ST8

  • The E-modulus of Novalyse ST8, ST14 and ST20 mixed with contrast agent was 18, 23 and 33kPa, respectively [7].

Analytical, diagnostic and therapeutic context of ST8

  • In Western blots the probe bound and specifically recognized a protein band corresponding to ST8 [3].
  • Analysis of 3'-azido-3'deoxythymidine-treated cells by all three methods showed a reduction in ST8 compared to control cells; treated cells had 73% of control levels by ELISA [3].
  • However, six cases, all with good outcomes, were caused by C:2b:(P1.2,P1.5) isolates of the same pulsed-field gel electrophoresis type belonging to ST8 complex/Cluster A4 [8].


  1. Blinded comparison of repetitive-sequence PCR and multilocus sequence typing for genotyping methicillin-resistant Staphylococcus aureus isolates from a children's hospital in St. Louis, Missouri. Liao, R.S., Storch, G.A., Buller, R.S., Orscheln, R.C., Mardis, E.R., Armstrong, J.R., Dunne, W.M. J. Clin. Microbiol. (2006) [Pubmed]
  2. International clones of methicillin-resistant Staphylococcus aureus in two hospitals in Miami, Florida. Chung, M., Dickinson, G., De Lencastre, H., Tomasz, A. J. Clin. Microbiol. (2004) [Pubmed]
  3. First synthetic probe for the detection and quantification of a protein with a potential alpha,(2-->8)sialyltransferase activity. D'Andrea, G., Lizzi, A.R., Oratore, A. Bioconjug. Chem. (2004) [Pubmed]
  4. Major epidemic clones of Staphylococcus aureus in Nigeria. Adesida, S., Boelens, H., Babajide, B., Kehinde, A., Snijders, S., van Leeuwen, W., Coker, A., Verbrugh, H., van Belkum, A. Microb. Drug Resist. (2005) [Pubmed]
  5. Panton-Valentine leukocidin positive MRSA in 2003: the Dutch situation. Wannet, W.J., Heck, M.E., Pluister, G.N., Spalburg, E., van Santen, M.G., Huijsdans, X.W., Tiemersma, E., de Neeling, A.J. Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin. (2004) [Pubmed]
  6. Characterisation of invasive meningococcal isolates from Italian children and adolescents. Mastrantonio, P., Sofia, T., Neri, A., Fazio, C., Stefanelli, P. Clin. Microbiol. Infect. (2007) [Pubmed]
  7. Development of fibrinous thrombus analogue for in-vitro abdominal aortic aneurysm studies. Hinnen, J.W., Rixen, D.J., Koning, O.H., van Bockel, J.H., Hamming, J.F. Journal of biomechanics (2007) [Pubmed]
  8. Invasive meningococcal disease associated with a very high case fatality rate in the North-West of Poland. Skoczyńska, A., Kadłubowski, M., Knap, J., Szulc, M., Janusz-Jurczyk, M., Hryniewicz, W. FEMS Immunol. Med. Microbiol. (2006) [Pubmed]
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