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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

New York

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Disease relevance of New York

  • Use of the polymerase chain reaction for early detection of the proviral sequences of human immunodeficiency virus in infants born to seropositive mothers. New York City Collaborative Study of Maternal HIV Transmission and Montefiore Medical Center HIV Perinatal Transmission Study Group [1].
  • METHODS: In an area of New York where Lyme disease is hyperendemic we conducted a randomized, double-blind, placebo-controlled trial of treatment with a single 200-mg dose of doxycycline in 482 subjects who had removed attached I. scapularis ticks from their bodies within the previous 72 hours [2].
  • The lower mortality in the enalapril arm was attributable to a reduction in the incidence of sudden death, and this beneficial effect was more prominent in patients with less severe symptoms (New York Heart Association class I or II) [3].
  • The association between prenatal care and birth weight among women exposed to cocaine in New York City: a correction [4].
  • CONCLUSION: In this population of New York City women, breast cancer was strongly associated with DDE in serum but not with PCBs [5].

Psychiatry related information on New York

  • Two hundred and sixty-one intravenous (IV) drug users, distributed between a methadone maintenance program and a large detention facility in New York City, were interviewed about knowledge of AIDS, needle use practices, and risk-reduction efforts [6].
  • OBJECTIVE: To study prospectively injection behavior of injecting drug users (IDU) who did and did not utilize a local needle exchange in the Bronx, New York City. DESIGN: Since 1985, IDU attending a methadone maintenance program have been enrolled in a prospective study of HIV-related risk behaviors [7].
  • The activity of COMT in erythrocytes was determined in 184 outpatients with primary affective disorder at the Lithium Clinic of the New York State Psychiatric Institute. COMT activity was determined by a modification of the Axelrod and Cohn method with dopamine as substrate [8].
  • An open study was carried out in 17 acutely ill, newly admitted, floridly psychotic schizophrenic patients to a city hospital in New York. Penfluridol was given on a daily basis up to doses of 120 mg and patients were rated objectively by means of different psychometric evaluations; vital signs were monitored daily as were side effects [9].
  • Patterns of utilization of mental health facilities in the United States and in Monroe County, New York, by economic variables and/or by race, for periods spanning the Great Society programs, are descirbed [10].

High impact information on New York

  • METHODS: A total of 5010 patients with heart failure of New York Heart Association (NYHA) class II, III, or IV were randomly assigned to receive 160 mg of valsartan or placebo twice daily [11].
  • Cocaine use, as measured by the detection of the metabolite benzoylecgonine in urine or blood, was found in 26.7 percent of all New York City residents receiving fatal injuries; free cocaine was detected in 18.3 percent [12].
  • All measures of functional capacity deteriorated in the patients receiving placebo as compared with those continuing to receive digoxin (P = 0.033 for maximal exercise tolerance, P = 0.01 for submaximal exercise endurance, and P = 0.019 for New York Heart Association class) [13].
  • From June 1990 through July 1991, intracerebral infection with the larval stage of the pork tapeworm Taenia solium was diagnosed in four unrelated persons in an Orthodox Jewish community in New York City. None of the patients had eaten pork, and only one had traveled to a country in which T. solium infection was endemic [14].
  • With a mean follow-up of seven months, the New York Heart Association Functional Class has been reduced from IV to II, and the number of days of hospitalization to less than 10 per cent of that before captopril therapy [15].

Chemical compound and disease context of New York


Biological context of New York


Anatomical context of New York

  • Fifty-five children with CID and known ADA status were studies at a workshop held in Albany, New York. Erythrocyte ADA determinations were performed in 22 of the 55 patients, 13 of whom were ADA negative [26].
  • Interview and dental examination data were gathered on 584 males with cancer of the oral cavity and on 1,222 control patients with nonneoplastic diseases at Roswell Park Memorial Institute, Buffalo, New York. No dietary characteristics distinguished cancer patients from controls [27].
  • This area contains a structure (Andrews, L. D., 1982, Freeze-fracture studies of vertebrate photoreceptors, In Structure of the Eye, J. G. Hollyfield and E. Acosta Vidrio, editors, Elsevier/North-Holland, New York, 11-23) that resembles the active zones of the nerve terminals for the frog neuromuscular junction [28].
  • The ouabain-resistant cell line H1C1 displays a 30-fold differential of reduced sensitivity to the structurally related cardiac glycosides digoxin and digitoxin (Baker, R. M. (1976) in Biogenesis and Turnover of Membrane Macromolecules (Cook, J.S., ed) pp. 93-103, Raven Press, New York) [29].
  • This correlation was independent of age, gender, body mass index, body fat, ejection fraction, New York Heart Association functional class, pulmonary function, plasma norepinephrine, angiotensin II, brain natriuretic peptide levels, and medications [30].

Associations of New York with chemical compounds

  • We also determined the population-based rates of fatal injuries that were known to follow cocaine use and the proportion of all deaths of New York City residents that was represented by these cases for each demographic stratum [12].
  • Potassium iodide: policy in New York [31].
  • The transit of an air mass containing radioactive gas released from the Three Mile Island reactor was recorded in Albany, New York, by measuring xenon-133 [32].
  • A screening for plasma cholesterol levels was conducted at six sites in the New York metropolitan area and involved hospitals, health professionals, paraprofessionals, media experts, and instruments that provided cholesterol levels rapidly [33].
  • Consequences of the 1989 New York State triplicate benzodiazepine prescription regulations [34].

Gene context of New York

  • Consecutive patients (n = 660) with breast cancer from the Memorial Sloan-Kettering Cancer Center (New York, NY) and healthy females (n = 880) from New York City were genotyped for the hypomorphic TGFBR1*6A allele and for the TGFB1 T29C variant that results in increased TGF-beta circulating levels [35].
  • METHODS: Circulating levels of tumor necrosis factor-alpha (TNF-alpha), and soluble TNF receptors (types 1 and 2), as well as interleukin (IL)-6 and IL-6 receptor were measured on a daily, weekly and monthly basis in heart failure patients (New York Heart Association class IIIa and IIIb; n = 10) and healthy volunteer subjects (n = 10) [36].
  • In this study, the abilities to inhibit IFN signaling of two closely related West Nile viruses, the New York 99 strain (NY99) and Kunjin virus (KUN), strain MRM61C, were analyzed using reporter plasmid assays, as well as immunofluorescence and Western blot analyses [37].
  • In the present study, the temporo-spatial expression of TNFR1 and TNFR2 was examined in rats that had received a 10 g impact injury dropped at a height of 12.5 mm using the New York University impact device [38].
  • We sought to replicate the GSTM1 finding in an independent case-control study from New York involving 89 cases [39].

Analytical, diagnostic and therapeutic context of New York

  • RESULTS--Multidrug-resistant M tuberculosis isolates were recovered from 253 New York City patients and had the same or closely allied IS6110 and PGRS patterns, multiplex PCR type, and gene mutations associated with resistance to rifampin, isoniazid, and streptomycin [40].
  • METHODS: We analyzed sera from the stored blood specimens of 14,290 participants enrolled between 1985 and 1991 in the New York University Women's Health Study, a prospective cohort study of hormones, diet, and cancer [5].
  • Antibodies against HTLV-related antigens were assayed by means of indirect living cell immunofluorescence of HTLV-infected cells in sera recently collected from Georgia haemophiliacs and in sera collected between 1976 and 1981 from New York haemophiliacs [41].
  • The patient, a 33-year-old man (90 kg, blood type O) with idiopathic cardiomyopathy, experienced end-organ heart failure (New York Heart Association [NYHA] class IV) while he was awaiting heart transplantation [42].
  • Dynamic cardiomyoplasty was indicated in 32 patients with dilated or chagasic cardiomyopathy who were in New York Heart Association (NYHA) class III or IV despite maximum medical therapy [43].


  1. Use of the polymerase chain reaction for early detection of the proviral sequences of human immunodeficiency virus in infants born to seropositive mothers. New York City Collaborative Study of Maternal HIV Transmission and Montefiore Medical Center HIV Perinatal Transmission Study Group. Rogers, M.F., Ou, C.Y., Rayfield, M., Thomas, P.A., Schoenbaum, E.E., Abrams, E., Krasinski, K., Selwyn, P.A., Moore, J., Kaul, A. N. Engl. J. Med. (1989) [Pubmed]
  2. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. Nadelman, R.B., Nowakowski, J., Fish, D., Falco, R.C., Freeman, K., McKenna, D., Welch, P., Marcus, R., Agüero-Rosenfeld, M.E., Dennis, D.T., Wormser, G.P. N. Engl. J. Med. (2001) [Pubmed]
  3. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. Cohn, J.N., Johnson, G., Ziesche, S., Cobb, F., Francis, G., Tristani, F., Smith, R., Dunkman, W.B., Loeb, H., Wong, M. N. Engl. J. Med. (1991) [Pubmed]
  4. The association between prenatal care and birth weight among women exposed to cocaine in New York City: a correction. Racine, A.D., Joyce, T.J., Anderson, R. JAMA (1994) [Pubmed]
  5. Blood levels of organochlorine residues and risk of breast cancer. Wolff, M.S., Toniolo, P.G., Lee, E.W., Rivera, M., Dubin, N. J. Natl. Cancer Inst. (1993) [Pubmed]
  6. Knowledge about AIDS and high-risk behavior among intravenous drug users in New York City. Selwyn, P.A., Feiner, C., Cox, C.P., Lipshutz, C., Cohen, R.L. AIDS (1987) [Pubmed]
  7. Needle exchange use among a cohort of injecting drug users. Schoenbaum, E.E., Hartel, D.M., Gourevitch, M.N. AIDS (1996) [Pubmed]
  8. Erythrocyte catechol-o-methyltransferase activity in primary affective disorder. Dunner, D.L., Levitt, M., Kumbaraci, T., Fieve, R.R. Biol. Psychiatry (1977) [Pubmed]
  9. Penfluridol: an open phase III study in acute newly admitted hospitalized schizophrenic patients. Shopsin, B., Klein, H., Gerbino, L., Selzer, G. Psychopharmacology (Berl.) (1977) [Pubmed]
  10. Mental health and the poor: have the gaps between the poor and the "nonpoor" narrowed in the last decade? Rosen, B.M. Medical care. (1977) [Pubmed]
  11. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. Cohn, J.N., Tognoni, G. N. Engl. J. Med. (2001) [Pubmed]
  12. Fatal injuries after cocaine use as a leading cause of death among young adults in New York City. Marzuk, P.M., Tardiff, K., Leon, A.C., Hirsch, C.S., Stajic, M., Portera, L., Hartwell, N., Iqbal, M.I. N. Engl. J. Med. (1995) [Pubmed]
  13. Withdrawal of digoxin from patients with chronic heart failure treated with angiotensin-converting-enzyme inhibitors. RADIANCE Study. Packer, M., Gheorghiade, M., Young, J.B., Costantini, P.J., Adams, K.F., Cody, R.J., Smith, L.K., Van Voorhees, L., Gourley, L.A., Jolly, M.K. N. Engl. J. Med. (1993) [Pubmed]
  14. Neurocysticercosis in an Orthodox Jewish community in New York City. Schantz, P.M., Moore, A.C., Muñoz, J.L., Hartman, B.J., Schaefer, J.A., Aron, A.M., Persaud, D., Sarti, E., Wilson, M., Flisser, A. N. Engl. J. Med. (1992) [Pubmed]
  15. Sustained effectiveness of converting-enzyme inhibition in patients with severe congestive heart failure. Dzau, V.J., Colucci, W.S., Williams, G.H., Curfman, G., Meggs, L., Hollenberg, N.K. N. Engl. J. Med. (1980) [Pubmed]
  16. Incidence of HIV infection in a New York City methadone maintenance treatment program. Orr, M.F., Glebatis, D., Friedmann, P., des Jarlais, D.C., Prevots, D.R. JAMA (1996) [Pubmed]
  17. Preferential association of human papillomavirus with high-grade histologic variants of penile-invasive squamous cell carcinoma. Gregoire, L., Cubilla, A.L., Reuter, V.E., Haas, G.P., Lancaster, W.D. J. Natl. Cancer Inst. (1995) [Pubmed]
  18. Vitamin A and lung cancer. Mettlin, C., Graham, S., Swanson, M. J. Natl. Cancer Inst. (1979) [Pubmed]
  19. Clinical and molecular epidemiology of acinetobacter infections sensitive only to polymyxin B and sulbactam. Go, E.S., Urban, C., Burns, J., Kreiswirth, B., Eisner, W., Mariano, N., Mosinka-Snipas, K., Rahal, J.J. Lancet (1994) [Pubmed]
  20. Effects of long-term treatment with calcium antagonists on left ventricular diastolic function in stable angina and heart failure. Lahiri, A., Rodrigues, E.A., Carboni, G.P., Raftery, E.B. Circulation (1990) [Pubmed]
  21. Actin' up (and down). Hyams, J.S. Trends Cell Biol. (2002) [Pubmed]
  22. Neurohumoral prediction of benefit from carvedilol in ischemic left ventricular dysfunction. Australia-New Zealand Heart Failure Group. Richards, A.M., Doughty, R., Nicholls, M.G., Macmahon, S., Ikram, H., Sharpe, N., Espiner, E.A., Frampton, C., Yandle, T.G. Circulation (1999) [Pubmed]
  23. Effects of hydralazine on coronary blood flow and myocardial energetics in congestive heart failure. Magorien, R.D., Brown, G.P., Unverferth, D.V., Nelson, S., Boudoulas, H., Bambach, D., Leier, C.V. Circulation (1982) [Pubmed]
  24. Nitroprusside and regional vascular capacitance in patients with severe congestive heart failure. Risöe, C., Simonsen, S., Rootwelt, K., Sire, S., Smiseth, O.A. Circulation (1992) [Pubmed]
  25. A new von Willebrand variant (type I, New York): increased ristocetin-induced platelet aggregation and plasma von Willebrand factor containing the full range of multimers. Weiss, H.J., Sussman, I.I. Blood (1986) [Pubmed]
  26. Abnormal spontaneous rosette formation and rosette inhibition in lung carcinoma. Gross, R.L., Latty, A., Williams, E.A., Newberne, P.M. N. Engl. J. Med. (1975) [Pubmed]
  27. Dentition, diet, tobacco, and alcohol in the epidemiology of oral cancer. Graham, S., Dayal, H., Rohrer, T., Swanson, M., Sultz, H., Shedd, D., Fischman, S. J. Natl. Cancer Inst. (1977) [Pubmed]
  28. Freeze-fracture studies of photoreceptor membranes: new observations bearing upon the distribution of cholesterol. Andrews, L.D., Cohen, A.I. J. Cell Biol. (1983) [Pubmed]
  29. Identification of an amino acid substitution in human alpha 1 Na,K-ATPase which confers differentially reduced affinity for two related cardiac glycosides. Askew, G.R., Lingrel, J.B. J. Biol. Chem. (1994) [Pubmed]
  30. Leptin and the ventilatory response to exercise in heart failure. Wolk, R., Johnson, B.D., Somers, V.K. J. Am. Coll. Cardiol. (2003) [Pubmed]
  31. Potassium iodide: policy in New York. Simon, N., Shils, M.E. Science (1983) [Pubmed]
  32. Radioactive plume from the Three Mile Island accident: xenon-133 in air at a distance of 375 kilometers. Wahlen, M., Kunz, C.O., Matuszek, J.M., Mahoney, W.E., Thompson, R.C. Science (1980) [Pubmed]
  33. Population screening for cholesterol determination. A pilot study. Wynder, E.L., Field, F., Haley, N.J. JAMA (1986) [Pubmed]
  34. Consequences of the 1989 New York State triplicate benzodiazepine prescription regulations. Weintraub, M., Singh, S., Byrne, L., Maharaj, K., Guttmacher, L. JAMA (1991) [Pubmed]
  35. Combined genetic assessment of transforming growth factor-beta signaling pathway variants may predict breast cancer risk. Kaklamani, V.G., Baddi, L., Liu, J., Rosman, D., Phukan, S., Bradley, C., Hegarty, C., McDaniel, B., Rademaker, A., Oddoux, C., Ostrer, H., Michel, L.S., Huang, H., Chen, Y., Ahsan, H., Offit, K., Pasche, B. Cancer Res. (2005) [Pubmed]
  36. Natural variability of circulating levels of cytokines and cytokine receptors in patients with heart failure: implications for clinical trials. Dibbs, Z., Thornby, J., White, B.G., Mann, D.L. J. Am. Coll. Cardiol. (1999) [Pubmed]
  37. Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins. Liu, W.J., Wang, X.J., Mokhonov, V.V., Shi, P.Y., Randall, R., Khromykh, A.A. J. Virol. (2005) [Pubmed]
  38. Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats. Yan, P., Liu, N., Kim, G.M., Xu, J., Xu, J., Li, Q., Hsu, C.Y., Xu, X.M. Exp. Neurol. (2003) [Pubmed]
  39. Xenobiotic metabolism genes and the risk of recurrent spontaneous abortion. Hirvonen, A., Taylor, J.A., Wilcox, A., Berkowitz, G., Schachter, B., Chaparro, C., Bell, D.A. Epidemiology (Cambridge, Mass.) (1996) [Pubmed]
  40. Origin and interstate spread of a New York City multidrug-resistant Mycobacterium tuberculosis clone family. Bifani, P.J., Plikaytis, B.B., Kapur, V., Stockbauer, K., Pan, X., Lutfey, M.L., Moghazeh, S.L., Eisner, W., Daniel, T.M., Kaplan, M.H., Crawford, J.T., Musser, J.M., Kreiswirth, B.N. JAMA (1996) [Pubmed]
  41. Antibodies to human T cell leukaemia virus-associated membrane antigens in haemophiliacs: evidence for infection before 1980. Evatt, B.L., Stein, S.F., Francis, D.P., Lawrence, D.N., McLane, M.F., McDougal, J.S., Lee, T.H., Spira, T.J., Cabradilla, C., Mullens, J.I., Essex, M. Lancet (1983) [Pubmed]
  42. First use of an untethered, vented electric left ventricular assist device for long-term support. Frazier, O.H. Circulation (1994) [Pubmed]
  43. Survival improvement with dynamic cardiomyoplasty in patients with dilated cardiomyopathy. Moreira, L.F., Seferian, P., Bocchi, E.A., Pêgo-Fernandes, P.M., Stolf, N.A., Pereira-Barretto, A.C., Jatene, A.D. Circulation (1991) [Pubmed]
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