Gene Review:
ST14 - suppression of tumorigenicity 14 (colon...
Homo sapiens
Synonyms:
ARCI11, HAI, MT-SP1, MTSP1, Matriptase, ...
- Protein interaction analysis of ST14 domains and their point and deletion mutants. Ge, W., Hu, H., Ding, K., Sun, L., Zheng, S. J. Biol. Chem. (2006)
- Effect of SNC19/ST14 gene overexpression on invasion of colorectal cancer cells. Ding, K.F., Sun, L.F., Ge, W.T., Hu, H.G., Zhang, S.Z., Zheng, S. World J. Gastroenterol. (2005)
- Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. Takeuchi, T., Harris, J.L., Huang, W., Yan, K.W., Coughlin, S.R., Craik, C.S. J. Biol. Chem. (2000)
- In vitro inhibition of matriptase prevents invasive growth of cell lines of prostate and colon carcinoma. Förbs, D., Thiel, S., Stella, M.C., Stürzebecher, A., Schweinitz, A., Steinmetzer, T., Stürzebecher, J., Uhland, K. Int. J. Oncol. (2005)
- Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract. Zeng, L., Cao, J., Zhang, X. World J. Gastroenterol. (2005)
- Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. List, K., Currie, B., Scharschmidt, T.C., Szabo, R., Shireman, J., Molinolo, A., Cravatt, B.F., Segre, J., Bugge, T.H. J. Biol. Chem. (2007)
- Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. List, K., Szabo, R., Molinolo, A., Sriuranpong, V., Redeye, V., Murdock, T., Burke, B., Nielsen, B.S., Gutkind, J.S., Bugge, T.H. Genes Dev. (2005)
- Recombination within DXS52 (ST14) locus in family with haemophilia A. Kirk, H.E., Robertson, K.A., Hay, C.W., Yong, S.L., McGillivray, B.C., Growe, G.H., MacGillivray, R.T. Lancet (1987)
- Engineering of a macromolecular scaffold to develop specific protease inhibitors. Stoop, A.A., Craik, C.S. Nat. Biotechnol. (2003)
- Deregulated activation of matriptase in breast cancer cells. Benaud, C.M., Oberst, M., Dickson, R.B., Lin, C.Y. Clin. Exp. Metastasis (2002)
- Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. Lin, C.Y., Anders, J., Johnson, M., Dickson, R.B. J. Biol. Chem. (1999)
- Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells. Kiyomiya, K., Lee, M.S., Tseng, I.C., Zuo, H., Barndt, R.J., Johnson, M.D., Dickson, R.B., Lin, C.Y. Am. J. Physiol., Cell Physiol. (2006)
- The cytotrophoblast layer of human chorionic villi becomes thinner but maintains its structural integrity during gestation. Mori, M., Ishikawa, G., Luo, S.S., Mishima, T., Goto, T., Robinson, J.M., Matsubara, S., Takeshita, T., Kataoka, H., Takizawa, T. Biol. Reprod. (2007)
- Analysis of linkage relationships between genetic markers around the fragile X locus with special reference to the daughters of normal transmitting males. Winter, R.M., Pembrey, M.E. Hum. Genet. (1986)
- Carrier detection in 50 haemophilia A kindred by means of three intragenic and two extragenic restriction fragment length polymorphisms. Moodie, P., Liddell, M.B., Peake, I.R., Bloom, A.L. Br. J. Haematol. (1988)
- Matriptase: potent proteolysis on the cell surface. List, K., Bugge, T.H., Szabo, R. Mol. Med. (2006)
- Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching. Ihara, S., Miyoshi, E., Ko, J.H., Murata, K., Nakahara, S., Honke, K., Dickson, R.B., Lin, C.Y., Taniguchi, N. J. Biol. Chem. (2002)
- Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. Benaud, C., Oberst, M., Hobson, J.P., Spiegel, S., Dickson, R.B., Lin, C.Y. J. Biol. Chem. (2002)
- Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease. Lee, S.L., Dickson, R.B., Lin, C.Y. J. Biol. Chem. (2000)
- Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. Lee, M.S., Kiyomiya, K., Benaud, C., Dickson, R.B., Lin, C.Y. Am. J. Physiol., Cell Physiol. (2005)
- Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25). Ahmed, S., Jin, X., Yagi, M., Yasuda, C., Sato, Y., Higashi, S., Lin, C.Y., Dickson, R.B., Miyazaki, K. FEBS J. (2006)
- Membrane-type serine protease-1/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis. Seitz, I., Hess, S., Schulz, H., Eckl, R., Busch, G., Montens, H.P., Brandl, R., Seidl, S., Schömig, A., Ott, I. Arterioscler. Thromb. Vasc. Biol. (2007)
- Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo. Oberst, M., Anders, J., Xie, B., Singh, B., Ossandon, M., Johnson, M., Dickson, R.B., Lin, C.Y. Am. J. Pathol. (2001)
- HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease. Oberst, M.D., Chen, L.Y., Kiyomiya, K., Williams, C.A., Lee, M.S., Johnson, M.D., Dickson, R.B., Lin, C.Y. Am. J. Physiol., Cell Physiol. (2005)
- Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. Friedrich, R., Fuentes-Prior, P., Ong, E., Coombs, G., Hunter, M., Oehler, R., Pierson, D., Gonzalez, R., Huber, R., Bode, W., Madison, E.L. J. Biol. Chem. (2002)
- Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor. Kataoka, H., Miyata, S., Uchinokura, S., Itoh, H. Cancer Metastasis Rev. (2003)
- A linkage study of a large pedigree with X linked centronuclear myopathy. Starr, J., Lamont, M., Iselius, L., Harvey, J., Heckmatt, J. J. Med. Genet. (1990)
- Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue. Takeuchi, T., Shuman, M.A., Craik, C.S. Proc. Natl. Acad. Sci. U.S.A. (1999)