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Gene Review

Sycn  -  syncollin

Mus musculus

Synonyms: 0910001K16Rik, 1810038B08Rik, SYL, Syncollin
 
 
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Disease relevance of Sycn

  • However, syncollin-deficient mice reacted to caerulein hyperstimulation with a more severe pancreatitis [1].
 

High impact information on Sycn

  • Syncollin is a small protein that is abundantly expressed in pancreatic acinar cells and that is tightly associated with the lumenal side of the zymogen granule membrane [1].
  • Syncollin in alkaline extracts of granule membranes was also monomeric [2].
  • These results indicate that syncollin is tightly bound to the luminal surface of the granule membrane [2].
  • When membranes were subjected to Triton X-114 partitioning, syncollin was found predominantly in the aqueous phase, indicating that it is not sufficiently hydrophobic to be embedded in the membrane [2].
  • In contrast, in non-ionic detergents such as Triton X-100, syncollin became partially sensitive to trypsin and behaved as a monomer [2].
 

Biological context of Sycn

 

Anatomical context of Sycn

 

Associations of Sycn with chemical compounds

  • When granule membranes were solubilized in ionic detergents such as deoxycholate, this trypsin resistance was maintained, and syncollin migrated on sucrose density gradients as a large (150 kDa) protein [2].
 

Regulatory relationships of Sycn

 

Other interactions of Sycn

  • Syncollin is required for efficient zymogen granule exocytosis [3].
  • A H(+)/Ca(2+) signal could significantly increase the specificity of the information sent by the granule by transmitting two frequency encoded messages targeted exclusively to proteins like calmodulin, annexins, or syncollin that are crucial for exocytosis and require specific combinations of [Ca(2+)] "and" pH for their action [6].

References

  1. Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion. Antonin, W., Wagner, M., Riedel, D., Brose, N., Jahn, R. Mol. Cell. Biol. (2002) [Pubmed]
  2. Analysis of the association of syncollin with the membrane of the pancreatic zymogen granule. An, S.J., Hansen, N.J., Hodel, A., Jahn, R., Edwardson, J.M. J. Biol. Chem. (2000) [Pubmed]
  3. Syncollin is required for efficient zymogen granule exocytosis. Wäsle, B., Turvey, M., Larina, O., Thorn, P., Skepper, J., Morton, A.J., Edwardson, J.M. Biochem. J. (2005) [Pubmed]
  4. The secretory granule protein syncollin localizes to HL-60 cells and neutrophils. Bach, J.P., Borta, H., Ackermann, W., Faust, F., Borchers, O., Schrader, M. J. Histochem. Cytochem. (2006) [Pubmed]
  5. Syncollin inhibits regulated corticotropin secretion from AtT-20 cells through a reduction in the secretory vesicle population. Wäsle, B., Hays, L.B., Rhodes, C.J., Edwardson, J.M. Biochem. J. (2004) [Pubmed]
  6. ATP-independent luminal oscillations and release of Ca2+ and H+ from mast cell secretory granules: implications for signal transduction. Quesada, I., Chin, W.C., Verdugo, P. Biophys. J. (2003) [Pubmed]
 
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