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Gene Review

TCTA  -  T-cell leukemia translocation altered

Homo sapiens

Synonyms: T-cell leukemia translocation-altered gene protein, T-cell leukemia translocation-associated gene protein
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Disease relevance of TCTA

  • Of note, genomic Southern blots demonstrated a reduced TCTA signal in three of four small cell lung cancer cell lines tested, suggesting loss of one of the two copies of the gene [1].
  • MSSP-1 produced in E. coli as a fusion protein with GST specifically interacted with single-stranded TCTTAT (plus myc(H-P)21) and ACT-ATT (in minus myc(H-P)21), the consensus of which can be referred to as A/TCTA/TA/TT [2].

High impact information on TCTA


Biological context of TCTA

  • The 4-kb canine TCTA gene consists of three exons and probably represents a pseudogene [6].
  • Transfection experiments have shown that c-myc induces HLA-B downregulation through a -68 to +13 base pairs (bp) core promoter fragment, containing CCAAT and TATA-like (TCTA) boxes [7].
  • The allele frequencies at the tetranucleotide repeat (TCTA) vWA locus in the vWF gene were determined in the general Finnish population, in a population representing an internal isolate of Finland, in the Vologda-Russian population, and in US Black population samples [8].
  • In total there were 9 distinguishable alleles found to increase in size by regular 4 bp increments from 134 to 170 bp with a repeat array following the pattern (TCTA)n TCA (TCTA)n. One-third of the sequenced alleles exhibited an altered repeat sequence TCTG TCTA at the 3' flanking region of the repeat array [9].

Anatomical context of TCTA

  • The two genes represent the corresponding canine orthologs of human aminomethyltransferase (AMT) and the human T-cell leukemia translocation associated (TCTA) gene [6].

Other interactions of TCTA


  1. Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. Aplan, P.D., Johnson, B.E., Russell, E., Chervinsky, D.S., Kirsch, I.R. Cancer Res. (1995) [Pubmed]
  2. Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene. Negishi, Y., Nishita, Y., Saëgusa, Y., Kakizaki, I., Galli, I., Kihara, F., Tamai, K., Miyajima, N., Iguchi-Ariga, S.M., Ariga, H. Oncogene (1994) [Pubmed]
  3. Structure of the gene for human von Willebrand factor. Mancuso, D.J., Tuley, E.A., Westfield, L.A., Worrall, N.K., Shelton-Inloes, B.B., Sorace, J.M., Alevy, Y.G., Sadler, J.E. J. Biol. Chem. (1989) [Pubmed]
  4. Mutation rate and specificity analysis of tetranucleotide microsatellite DNA alleles in somatic human cells. Eckert, K.A., Yan, G., Hile, S.E. Mol. Carcinog. (2002) [Pubmed]
  5. The short tandem repeat locus VWF2 in Intron 40 of the von Willebrand factor gene consists of two polymorphic sub-loci. Haddad, A.P., Sparrow, R.L. Forensic Sci. Int. (2001) [Pubmed]
  6. Genomic structures and sequences of two closely linked genes (AMT, TCTA) on dog chromosome 20q15.1-->q15.2. Leeb, T., Breen, M., Brenig, B. Cytogenet. Cell Genet. (2000) [Pubmed]
  7. Repression of the minimal HLA-B promoter by c-myc and p53 occurs through independent mechanisms. Griffioen, M., Steegenga, W.T., Ouwerkerk, I.J., Peltenburg, L.T., Jochemsen, A.G., Schrier, P.I. Mol. Immunol. (1998) [Pubmed]
  8. A microsatellite polymorphism in the von Willebrand factor gene: comparison of allele frequencies in different population samples and evaluation for forensic medicine. Sajantila, A., Pacek, P., Lukka, M., Syvänen, A.C., Nokelainen, P., Sistonen, P., Peltonen, L., Budowle, B. Forensic Sci. Int. (1994) [Pubmed]
  9. Tetranucleotide STR system D8S1132: sequencing data and population genetic comparisons. Wiegand, P., Schneider, H.R., Schürenkamp, M., Kleiber, M., Brinkmann, B. Int. J. Legal Med. (1998) [Pubmed]
  10. Histological analysis and ancient DNA amplification of human bone remains found in caius iulius polybius house in pompeii. Cipollaro, M., Di Bernado, G., Forte, A., Galano, G., De Masi, L., Galderisi, U., Guarino, F.M., Angelini, F., Cascino, A. Croat. Med. J. (1999) [Pubmed]
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