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Gene Review

Kynu  -  kynureninase (L-kynurenine hydrolase)

Mus musculus

Synonyms: 4432411A05Rik, Kynureninase, L-kynurenine hydrolase
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Disease relevance of Kynu

  • RESULTS: Levels of mRNA for IDO (indoleamine 2,3-dioxygenase) and kynureninase, enzymes constituting the tryptophan degradation pathway, were found to be upregulated in the skin lesions as compared to the uninvolved skin of patients with AD or psoriasis [1].

High impact information on Kynu


Associations of Kynu with chemical compounds


Other interactions of Kynu


  1. Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis. Ito, M., Ogawa, K., Takeuchi, K., Nakada, A., Heishi, M., Suto, H., Mitsuishi, K., Sugita, Y., Ogawa, H., Ra, C. J. Dermatol. Sci. (2004) [Pubmed]
  2. Effects of mitochondria and o-methoxybenzoylalanine on 3-hydroxyanthranilic acid dioxygenase activity and quinolinic acid synthesis. Chiarugi, A., Moroni, F. J. Neurochem. (1999) [Pubmed]
  3. Regulation of the kynurenine metabolic pathway by interferon-gamma in murine cloned macrophages and microglial cells. Alberati-Giani, D., Ricciardi-Castagnoli, P., Köhler, C., Cesura, A.M. J. Neurochem. (1996) [Pubmed]
  4. Kynurenine disposition in blood and brain of mice: effects of selective inhibitors of kynurenine hydroxylase and of kynureninase. Chiarugi, A., Carpenedo, R., Moroni, F. J. Neurochem. (1996) [Pubmed]
  5. Response of kynurenine pathway enzymes to pregnancy and dietary level of vitamin B-6. van de Kamp, J.L., Smolen, A. Pharmacol. Biochem. Behav. (1995) [Pubmed]
  6. Tryptophan metabolism in vitamin B6-deficient mice. Bender, D.A., Njagi, E.N., Danielian, P.S. Br. J. Nutr. (1990) [Pubmed]
  7. Regulation of quinolinic acid synthesis by mitochondria and o-methoxybenzoylalanine. Chiarugi, A., Moroni, F. Adv. Exp. Med. Biol. (1999) [Pubmed]
  8. The contribution of tryptophan to the regulation of the NAD+ level in mouse liver. Streffer, C. Acta Vitaminol. Enzymol. (1975) [Pubmed]
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