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Gene Review

KYNU  -  kynureninase

Homo sapiens

Synonyms: Kynureninase, L-kynurenine hydrolase
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Disease relevance of KYNU


High impact information on KYNU


Chemical compound and disease context of KYNU


Biological context of KYNU


Anatomical context of KYNU


Associations of KYNU with chemical compounds


Other interactions of KYNU


  1. A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. Heyes, M.P., Saito, K., Major, E.O., Milstien, S., Markey, S.P., Vickers, J.H. Brain (1993) [Pubmed]
  2. Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation. Saito, K., Nowak, T.S., Suyama, K., Quearry, B.J., Saito, M., Crowley, J.S., Markey, S.P., Heyes, M.P. J. Neurochem. (1993) [Pubmed]
  3. Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens. Koushik, S.V., Sundararaju, B., McGraw, R.A., Phillips, R.S. Arch. Biochem. Biophys. (1997) [Pubmed]
  4. Purification and biochemical characterization of some of the properties of recombinant human kynureninase. Walsh, H.A., Botting, N.P. Eur. J. Biochem. (2002) [Pubmed]
  5. A mechanism for increased quinolinic acid formation following acute systemic immune stimulation. Saito, K., Crowley, J.S., Markey, S.P., Heyes, M.P. J. Biol. Chem. (1993) [Pubmed]
  6. Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types. Heyes, M.P., Chen, C.Y., Major, E.O., Saito, K. Biochem. J. (1997) [Pubmed]
  7. Dynamic diversity of the tryptophan pathway in chlamydiae: reductive evolution and a novel operon for tryptophan recapture. Xie, G., Bonner, C.A., Jensen, R.A. Genome Biol. (2002) [Pubmed]
  8. Involvement of tryptophan metabolism in the body color of crustacea. Negishi, S., Hasegawa, Y., Naito, J., Nagamura, Y., Ishiguro, I. Adv. Exp. Med. Biol. (1999) [Pubmed]
  9. Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia. Saito, K., Nowak, T.S., Markey, S.P., Heyes, M.P. J. Neurochem. (1993) [Pubmed]
  10. High-performance liquid chromatographic assay of human lymphocyte kynureninase activity levels. Ubbink, J.B., Vermaak, W.J., Bissbort, S.H. J. Chromatogr. (1991) [Pubmed]
  11. Kynurenine hydroxylase and kynureninase inhibitors as tools to study the role of kynurenine metabolites in the central nervous system. Moroni, F., Carpenedo, R., Chiarugi, A. Adv. Exp. Med. Biol. (1996) [Pubmed]
  12. Expression of the kynurenine pathway enzymes in human microglia and macrophages. Guillemin, G.J., Smith, D.G., Smythe, G.A., Armati, P.J., Brew, B.J. Adv. Exp. Med. Biol. (2003) [Pubmed]
  13. Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase. Christensen, M., Duno, M., Lund, A.M., Skovby, F., Christensen, E. J. Inherit. Metab. Dis. (2007) [Pubmed]
  14. A comparative study on the inhibition of human and bacterial kynureninase by novel bicyclic kynurenine analogues. Fitzgerald, D.H., Muirhead, K.M., Botting, N.P. Bioorg. Med. Chem. (2001) [Pubmed]
  15. S-aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase. Drysdale, M.J., Reinhard, J.F. Bioorg. Med. Chem. Lett. (1998) [Pubmed]
  16. The kynurenine load test, an adjunct to the tryptophan load test. Wolf, H., Brown, R.R., Arend, R.A. Scand. J. Clin. Lab. Invest. (1980) [Pubmed]
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