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Gene Review

Kynu  -  kynureninase

Rattus norvegicus

Synonyms: Kynureninase, L-kynurenine hydrolase
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Disease relevance of Kynu


Psychiatry related information on Kynu

  • This makes kynureninase a possible therapeutic target for diseases such as Huntington's, Alzheimer's and AIDS related dementia, and the development of potent inhibitors an important research aim [4].

High impact information on Kynu


Chemical compound and disease context of Kynu

  • Vitamin B-6 status was evaluated according to several biological criteria (weight gain, urinary excretion of xanthurenic acid after tryptophan loading, plasma pyridoxal 5'-phosphate, apparent pyridoxal 5'-phosphate-saturation of liver kynureninase, urinary excretion of 4-pyridoxic acid and fecal output of vitamin B-6) [8].
  • RESULTS: Two new kynurenine analogues, 3-hydroxydesaminokynurenine and 3-methoxydesaminokynurenine, were synthesised as inhibitors of kynureninase and tested on the tryptophan-induced bacterial enzyme from Pseudomonas fluorescens, the recombinant human enzyme and the rat hepatic enzyme [4].

Biological context of Kynu


Anatomical context of Kynu


Associations of Kynu with chemical compounds


Other interactions of Kynu


Analytical, diagnostic and therapeutic context of Kynu

  • Northern blot analysis revealed the synthesis of a 2.0 kb rat kynureninase mRNA [9].
  • Kynureninase activity was measured in various organs of the rat by a sensitive assay method based on the use of an HPLC system [19].


  1. Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats. Mizutani, K., Sugimoto, K., Okuda, T., Katsuya, T., Miyata, T., Tanabe, T., Higaki, J., Ogihara, T., Yamori, Y., Tsujita, Y., Tago, N., Iwai, N. Hypertens. Res. (2002) [Pubmed]
  2. Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens. Koushik, S.V., Sundararaju, B., McGraw, R.A., Phillips, R.S. Arch. Biochem. Biophys. (1997) [Pubmed]
  3. Effect of psoralen-induced photodermatitis on tryptophan metabolism in rats. De Antoni, A., Costa, C., Allegri, G., Baccichetti, F., Vanzan, S. Chem. Biol. Interact. (1981) [Pubmed]
  4. Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. Walsh, H.A., O'Shea, K.C., Botting, N.P. BMC Biochem. (2003) [Pubmed]
  5. Isolation and characterization of a rat liver enzyme with both cysteine conjugate beta-lyase and kynureninase activity. Stevens, J.L. J. Biol. Chem. (1985) [Pubmed]
  6. Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency. Saito, K., Fujigaki, S., Heyes, M.P., Shibata, K., Takemura, M., Fujii, H., Wada, H., Noma, A., Seishima, M. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  7. Metabolism of [5-3H]kynurenine in the rat brain in vivo: evidence for the existence of a functional kynurenine pathway. Guidetti, P., Eastman, C.L., Schwarcz, R. J. Neurochem. (1995) [Pubmed]
  8. Konjac mannan improves the vitamin B-6 status of rats fed a vitamin B-6-deficient diet. Hayakawa, T., Iida, Y., Tsuge, H. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1999) [Pubmed]
  9. Cloning and recombinant expression of rat and human kynureninase. Toma, S., Nakamura, M., Toné, S., Okuno, E., Kido, R., Breton, J., Avanzi, N., Cozzi, L., Speciale, C., Mostardini, M., Gatti, S., Benatti, L. FEBS Lett. (1997) [Pubmed]
  10. Isolation and expression of a cDNA clone encoding human kynureninase. Alberati-Giani, D., Buchli, R., Malherbe, P., Broger, C., Lang, G., Köhler, C., Lahm, H.W., Cesura, A.M. Eur. J. Biochem. (1996) [Pubmed]
  11. Amino-acid sequence of rat liver kynureninase. Takeuchi, F., Tsubouchi, R., Yoshino, M., Shibata, Y. Biochim. Biophys. Acta (1995) [Pubmed]
  12. The metabolism of L-tryptophan by isolated rat liver cells. Quantification of the relative importance of, and the effect of nutritional status on, the individual pathways of tryptophan metabolism. Smith, S.A., Carr, F.P., Pogson, C.I. Biochem. J. (1980) [Pubmed]
  13. Quantification of the importance of individual steps in the control of aromatic amino acid metabolism. Salter, M., Knowles, R.G., Pogson, C.I. Biochem. J. (1986) [Pubmed]
  14. Role of kynurenines in the neurotoxic actions of kainic acid. Behan, W.M., Stone, T.W. Br. J. Pharmacol. (2000) [Pubmed]
  15. Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase. Chiarugi, A., Carpenedo, R., Molina, M.T., Mattoli, L., Pellicciari, R., Moroni, F. J. Neurochem. (1995) [Pubmed]
  16. The role of tryptophan 2,3-dioxygenase in the hormonal control of tryptophan metabolism in isolated rat liver cells. Effects of glucocorticoids and experimental diabetes. Salter, M., Pogson, C.I. Biochem. J. (1985) [Pubmed]
  17. The effect of pyridoxine deficiency on the metabolism of the aromatic amino acids by isolated rat liver cells. Stanley, J.C., Salter, M., Fisher, M.J., Pogson, C.I. Arch. Biochem. Biophys. (1985) [Pubmed]
  18. Peripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure. Pawlak, D., Tankiewicz, A., Matys, T., Buczko, W. J. Physiol. Pharmacol. (2003) [Pubmed]
  19. Organ distribution of rat kynureninase and changes of its activity during development. Kawai, J., Okuno, E., Kido, R. Enzyme (1988) [Pubmed]
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