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Gene Review:

TLE2 - transducin-like enhancer of split 2

Homo sapiens

Synonyms: ESG, ESG2, Enhancer of split groucho-like protein 2, FLJ41188, GRG2, ...

Gambi, D. et al., Yao, J. et al., DE LA Rosa, M.G. et al., Aghaallaei, N. et al., Javed, A. et al., et al.

Bernard, Alata, Francaux,

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Disease relevance of TLE2

These included 72 controls (C), 659 early and suspect open angle glaucoma (ESG) with perimetric mean defect (MD) lower than 6 dB, and 242 confirmed moderate and advanced glaucomas (AG) with perimetric MD >/=6 dB [1].
Thirty subjects affected with multiple sclerosis, of which 22 were female and eight male, with an average of 30 +/- 7, years were studied, for a period of 10-15 months,. clinically using Kurtzkes' report form, neurophysiologically (responses tested: VEP, BAEP, SEP, ESG) and immunologically (Rosette Et, Ea, EAC) [2].

High impact information on TLE2

Remarkably, this repression domain interacts specifically with hGrg, TLE1, and TLE2 proteins, all of which are members of the Groucho family of transcriptional corepressors [3].
Database searches of genomic sequences revealed an identical set of Tle paralogues being present in distantly related fish species, indicating duplicated Tle2 and Tle3 genes for the complete teleost lineage [4].
On the modeling of breath-by-breath oxygen uptake kinetics at the onset of high-intensity exercises: simulated annealing vs. GRG2 method [5].
In contrast, later stages correlate with up-regulation of TLE2 and TLE4, and decreased expression of TLE1 [6].

Anatomical context of TLE2

Digital immunofluorescence microscopy results show that TLE1 and TLE2 are both associated with the nuclear matrix, and that a significant subset of each colocalizes with AML transcription factors [7].
In addition, Grg2, Grg4 and Grg5 are expressed in the notochord [8].

Regulatory relationships of TLE2

TLE1 is up-regulated and TLE2 and TLE4 are down-regulated to different extents during early stages of differentiation [6].

References

Optic disc tomography and perimetry in controls, glaucoma suspects, and early and established glaucomas. DE LA Rosa, M.G., Gonzalez-Hernandez, M., Lozano-Lopez, V., Mendez, M.S., DE LA Vega, R.R. Optometry and vision science : official publication of the American Academy of Optometry (2007) [Pubmed]
Longitudinal study of clinical, neurophysiological and immunological parameters in multiple sclerosis. Preliminary investigation. Gambi, D., Rossini, P.M., Marchionno, L., Ricci, L., Barboni, F., Di Primio, R., Battista, P. International journal of tissue reactions. (1981) [Pubmed]
PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Ren, B., Chee, K.J., Kim, T.H., Maniatis, T. Genes Dev. (1999) [Pubmed]
Duplicated members of the Groucho/Tle gene family in fish. Aghaallaei, N., Bajoghli, B., Walter, I., Czerny, T. Dev. Dyn. (2005) [Pubmed]
On the modeling of breath-by-breath oxygen uptake kinetics at the onset of high-intensity exercises: simulated annealing vs. GRG2 method. Bernard, O., Alata, O., Francaux, M. J. Appl. Physiol. (2006) [Pubmed]
Combinatorial expression patterns of individual TLE proteins during cell determination and differentiation suggest non-redundant functions for mammalian homologs of Drosophila Groucho. Yao, J., Liu, Y., Husain, J., Lo, R., Palaparti, A., Henderson, J., Stifani, S. Dev. Growth Differ. (1998) [Pubmed]
Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. Javed, A., Guo, B., Hiebert, S., Choi, J.Y., Green, J., Zhao, S.C., Osborne, M.A., Stifani, S., Stein, J.L., Lian, J.B., van Wijnen, A.J., Stein, G.S. J. Cell. Sci. (2000) [Pubmed]
Expression of avian Groucho-related genes (Grgs) during embryonic development. Van Hateren, N., Belsham, A., Randall, V., Borycki, A.G. Gene Expr. Patterns (2005) [Pubmed]

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