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Gene Review

RNF14  -  ring finger protein 14

Homo sapiens

Synonyms: ARA54, Androgen receptor-associated protein 54, E3 ubiquitin-protein ligase RNF14, HFB30, HRIHFB2038, ...
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Disease relevance of RNF14


High impact information on RNF14


Biological context of RNF14

  • A human cDNA, HFB30, encoding a novel protein that contains a RING finger (C3HC4-type zinc finger) motif was isolated [6].

Anatomical context of RNF14

  • Ubiquitination of wild-type ARA54 and RNF8, expressed in COS-7 cells, was also observed, and a proteasome inhibitor, MG132, prevented the degradation of these wild-type proteins, but was much less effective in protecting the RING mutants [5].
  • In transient transfection assays of prostate cancer cell lines, the mt-ARA54 suppressed endogenous mutated AR-mediated and exogenous wild-type AR-mediated transactivation in LNCaP and PC-3 cells, respectively [3].

Regulatory relationships of RNF14


Other interactions of RNF14

  • In this study, we performed yeast two-hybrid screening for protein(s) interacting with UBE2E2, and two RING-finger proteins, ARA54 and RNF8, were identified [5].
  • We first identified the AR-LBD coregulators ARA70, ARA55, and ARA54 [7].
  • Here we describe transgelin as the first ARA54-associated negative modulator for AR [4].


  1. Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. Kang, H.Y., Yeh, S., Fujimoto, N., Chang, C. J. Biol. Chem. (1999) [Pubmed]
  2. The use of phage display technique for the isolation of androgen receptor interacting peptides with (F/W)XXL(F/W) and FXXLY new signature motifs. Hsu, C.L., Chen, Y.L., Yeh, S., Ting, H.J., Hu, Y.C., Lin, H., Wang, X., Chang, C. J. Biol. Chem. (2003) [Pubmed]
  3. A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth. Miyamoto, H., Rahman, M., Takatera, H., Kang, H.Y., Yeh, S., Chang, H.C., Nishimura, K., Fujimoto, N., Chang, C. J. Biol. Chem. (2002) [Pubmed]
  4. Transgelin Functions as a Suppressor via Inhibition of ARA54-Enhanced Androgen Receptor Transactivation and Prostate Cancer Cell Growth. Yang, Z., Chang, Y.J., Miyamoto, H., Ni, J., Niu, Y., Chen, Z., Chen, Y.L., Yao, J.L., di Sant'agnese, P.A., Chang, C. Mol. Endocrinol. (2007) [Pubmed]
  5. N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. Ito, K., Adachi, S., Iwakami, R., Yasuda, H., Muto, Y., Seki, N., Okano, Y. Eur. J. Biochem. (2001) [Pubmed]
  6. Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif. Ueki, N., Seki, N., Yano, K., Masuho, Y., Saito, T., Muramatsu, M. Biochim. Biophys. Acta (1999) [Pubmed]
  7. Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer. Yeh, S., Sampson, E.R., Lee, D.K., Kim, E., Hsu, C.L., Chen, Y.L., Chang, H.C., Altuwaijri, S., Huang, K.E., Chang, C. J. Formos. Med. Assoc. (2000) [Pubmed]
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