Disease relevance of Gorasp1

• Monoclonal antibodies to Escherichia coli-expressed P46 and P65 membranous proteins for specific immunodetection of Mycoplasma hyopneumoniae in lungs of infected pigs [1].

High impact information on Gorasp1

• Immunohistochemically there was more marked staining for iNOS and P65 expression in rats given gentamicin than in the control and group 3 and 4 (P < 0.001) [2].
• In contrast, RAW cells grown in EPA-rich media had less TNF mRNA expression and an altered composition of the NF kappa B subunits (P65/P50 dimers) in the presence of LPS [3].
• The NF-kappaB protein P65, although expressed in the endothelial cell cytoplasm after LDL injection, was not observed within the cell nucleus [4].
• P65 protein was detected in stromal cells, epithelial cells of endometrium as well as in myometrium [5].
• Hemispheres of aldehyde perfused mice, at various ages from P6 to P65 (DOB = P0; three each), were osmicated and sectioned at 40 microns parallel to the pia [6].

Analytical, diagnostic and therapeutic context of Gorasp1

• Based on the genomic sequence of the reference strain ATCC 25934, primers were designed for PCR amplification of the genes encoding entire P46 (1,260 bp) and P65 (1,803 bp) and N-terminally truncated P65(c) (1,200 bp) [1].

References