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Gene Review

Gorasp1  -  golgi reassembly stacking protein 1

Mus musculus

Synonyms: 5430411C10Rik, GOLPH5, GRASP65, Golgi peripheral membrane protein p65, Golgi reassembly-stacking protein 1, ...
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Disease relevance of Gorasp1

  • Monoclonal antibodies to Escherichia coli-expressed P46 and P65 membranous proteins for specific immunodetection of Mycoplasma hyopneumoniae in lungs of infected pigs [1].

High impact information on Gorasp1

  • Immunohistochemically there was more marked staining for iNOS and P65 expression in rats given gentamicin than in the control and group 3 and 4 (P < 0.001) [2].
  • In contrast, RAW cells grown in EPA-rich media had less TNF mRNA expression and an altered composition of the NF kappa B subunits (P65/P50 dimers) in the presence of LPS [3].
  • The NF-kappaB protein P65, although expressed in the endothelial cell cytoplasm after LDL injection, was not observed within the cell nucleus [4].
  • P65 protein was detected in stromal cells, epithelial cells of endometrium as well as in myometrium [5].
  • Hemispheres of aldehyde perfused mice, at various ages from P6 to P65 (DOB = P0; three each), were osmicated and sectioned at 40 microns parallel to the pia [6].

Analytical, diagnostic and therapeutic context of Gorasp1

  • Based on the genomic sequence of the reference strain ATCC 25934, primers were designed for PCR amplification of the genes encoding entire P46 (1,260 bp) and P65 (1,803 bp) and N-terminally truncated P65(c) (1,200 bp) [1].


  1. Monoclonal antibodies to Escherichia coli-expressed P46 and P65 membranous proteins for specific immunodetection of Mycoplasma hyopneumoniae in lungs of infected pigs. Cheikh Saad Bouh, K., Shareck, F., Dea, S. Clin. Diagn. Lab. Immunol. (2003) [Pubmed]
  2. Selective nuclear factor kappa-B inhibitors, pyrolidium dithiocarbamate and sulfasalazine, prevent the nephrotoxicity induced by gentamicin. Tugcu, V., Ozbek, E., Tasci, A.I., Kemahli, E., Somay, A., Bas, M., Karaca, C., Altug, T., Cekmen, M.B., Ozdogan, H.K. BJU Int. (2006) [Pubmed]
  3. Fish oil decreases macrophage tumor necrosis factor gene transcription by altering the NF kappa B activity. Lo, C.J., Chiu, K.C., Fu, M., Lo, R., Helton, S. J. Surg. Res. (1999) [Pubmed]
  4. In vivo low-density lipoprotein exposure induces intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 correlated with activator protein-1 expression. Verna, L., Ganda, C., Stemerman, M.B. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  5. Expression of nuclear factor-kappaB in mouse uterus during peri-implantation. Xie, Q., Xin, Z., Cao, L., Li, W. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2004) [Pubmed]
  6. A survey of morphogenesis during the early postnatal period in PMBSF barrels of mouse SmI cortex with emphasis on barrel D4. White, E.L., Weinfeld, L., Lev, D.L. Somatosensory & motor research. (1997) [Pubmed]
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