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Gene Review

Pank1  -  pantothenate kinase 1

Mus musculus

Synonyms: 4632412I06Rik, 5430426F23Rik, Pank, Pank1a, Pank1b, ...
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Disease relevance of Pank1


High impact information on Pank1


Biological context of Pank1


Anatomical context of Pank1


Associations of Pank1 with chemical compounds

  • Pantothenate kinase (PanK) is the key regulatory enzyme in the CoA biosynthetic pathway in bacteria and is thought to play a similar role in mammalian cells [9].
  • Liver PAK from genetically diabetic mice was inhibited by acetyl-CoA to the same extent as enzyme from nondiabetic mice and by CoASH to nearly the same extent [8].
  • These changes were accompanied by significant decreases in pantothenate and increases in 4-phosphopantothenate suggesting an increase in pantothenate kinase activity due to reduction of CoA inhibition of the enzyme [10].
  • Findings support the CoA depletion mechanism of valproate inhibition of beta-oxidation and other CoA- and acetyl CoA-requiring enzymic reactions and stress the role of carnitine in the regulation of CoA synthesis at the site of action of pantothenate kinase [11].


  1. Hereditary causes of disturbed iron homeostasis in the central nervous system. Ponka, P. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  2. Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters. Zhang, Y.M., Rock, C.O., Jackowski, S. J. Biol. Chem. (2005) [Pubmed]
  3. Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis. Zhyvoloup, A., Nemazanyy, I., Babich, A., Panasyuk, G., Pobigailo, N., Vudmaska, M., Naidenov, V., Kukharenko, O., Palchevskii, S., Savinska, L., Ovcharenko, G., Verdier, F., Valovka, T., Fenton, T., Rebholz, H., Wang, M.L., Shepherd, P., Matsuka, G., Filonenko, V., Gout, I.T. J. Biol. Chem. (2002) [Pubmed]
  4. Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme a homeostasis. Zhang, Y.M., Chohnan, S., Virga, K.G., Stevens, R.D., Ilkayeva, O.R., Wenner, B.R., Bain, J.R., Newgard, C.B., Lee, R.E., Rock, C.O., Jackowski, S. Chem. Biol. (2007) [Pubmed]
  5. Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite. Saliba, K.J., Ferru, I., Kirk, K. Antimicrob. Agents Chemother. (2005) [Pubmed]
  6. fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster. Afshar, K., Gönczy, P., DiNardo, S., Wasserman, S.A. Genetics (2001) [Pubmed]
  7. The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes. Rock, C.O., Karim, M.A., Zhang, Y.M., Jackowski, S. Gene (2002) [Pubmed]
  8. Pantothenate kinase activity in livers of genetically diabetic mice (db/db) and hormonally treated cultured rat hepatocytes. Kirschbaum, N., Clemons, R., Marino, K.A., Sheedy, G., Nguyen, M.L., Smith, C.M. J. Nutr. (1990) [Pubmed]
  9. Pantothenate kinase regulation of the intracellular concentration of coenzyme A. Rock, C.O., Calder, R.B., Karim, M.A., Jackowski, S. J. Biol. Chem. (2000) [Pubmed]
  10. The effect of tumour growth on liver pantothenate, CoA, and fatty acid synthetase activity in the mouse. McAllister, R.A., Fixter, L.M., Campbell, E.H. Br. J. Cancer (1988) [Pubmed]
  11. Amelioration of adverse effects of valproic acid on ketogenesis and liver coenzyme A metabolism by cotreatment with pantothenate and carnitine in developing mice: possible clinical significance. Thurston, J.H., Hauhart, R.E. Pediatr. Res. (1992) [Pubmed]
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