Disease relevance of DL-Pantothenyl alcohol

• CONCLUSIONS: We provide evidence that prophylactic and ongoing use of topical therapy with either topical corticosteroid or a dexpanthenol-containing emollient ameliorates, but does not prevent radiation dermatitis [1].
• Dexpanthenol enemas in ulcerative colitis: a pilot study [2].
• Effects of dexpanthenol with or without Aloe vera extract on radiation-induced oral mucositis: preclinical studies [3].
• OBJECTIVES: To compare treatment with topical 0.1% methylprednisolone vs. 0.5% dexpanthenol in a cohort of patients undergoing fractionated radiation therapy for breast cancer [1].
• Allergic contact dermatitis due to panthenol [4].

High impact information on DL-Pantothenyl alcohol

• Instead, pantothenol inhibited the in vitro growth of P. falciparum via a mechanism that involves competition with pantothenate and which can be attributed to inhibition of the parasite's pantothenate kinase [5].
• CONCLUSION: In direct comparison with dexpanthenol-containing lotion, no advantage for Thêta-Cream was found [6].
• Background: In this study, we aimed to compare the effectiveness of dexpanthenol pastille and benzydamine hydrochloride spray on the prevention of a sore throat [7].
• Allergic contact dermatitis to panthenol and cocamidopropyl PG dimonium chloride phosphate in a facial hydrating lotion [8].
• The initiation of a study to evaluate the efficacy of dexpanthenol in preventing irritant occupational contact dermatitis under real workplace conditions is validated [9].

Chemical compound and disease context of DL-Pantothenyl alcohol

• CONCLUSION: Topically administered dexpanthenol seems to be absorbed, but at the dose used in this study, it did not influence concentrations of colonic coenzyme A activity, fecal short-chain fatty acids, or clinical response in patients with active left-sided ulcerative colitis [2].
• Maintenance of hand eczema by oral pantothenic acid in a patient sensitized to dexpanthenol [10].
• In a patient with contact dermatitis, dexpanthenol was found to be the causative allergen [11].
• Dexpanthenol pastille and benzydamine hydrochloride spray for the prevention of post-operative sore throat [7].
• In all patients mucositis prophylaxis with nystatin, rutosides, panthenol and immunoglobulin was undertaken [12].

Biological context of DL-Pantothenyl alcohol

• The second is a sensitive and reliable modified fluorimetric method is also suggested, whereas panthenol, after alkaline hydrolysis is treated with ninhydrin [13].
• In double-blind placebo-controlled clinical trials, dexpanthenol was evaluated for its efficacy in improving wound healing [14].
• RESULTS: Dexpanthenol significantly reduces the toxic effects of xylometazoline regarding cell growth (p < 0.001) when applied in advance [15].

Anatomical context of DL-Pantothenyl alcohol

• Allergic contact reaction to dexpanthenol: lymphocyte transformation test and evidence for microsomal-dependent metabolism of the allergen [11].
• Flunixin meglumine, dipyrone, and panthenol had no effect on the motility of the jejunum or pelvic flexure [16].
• The systemic application of prednisolone (2 mg/kg per day i.m.) and topical 5% dexpanthenol ointment resulted in an acceleration of late epithelial wound closure together with a reduction in hyperplastic granulation tissue [17].
• We were able to show effects of D-panthenol, L-lysine, and miliacin on proliferation and metabolic capacity of keratinocyte monocell culture, which was further increased by combination of the three substances [18].
• Activation of fibroblast proliferation, which is of relevance in wound healing, has been observed both in vitro and in vivo with dexpanthenol [14].

Gene context of DL-Pantothenyl alcohol

• In a randomized, double-blind, placebo-controlled study the effect of topical dexpanthenol (CAS 81-13-0) formulated in two different lipophilic vehicles on epidermal barrier function in vivo was carried out [19].

Analytical, diagnostic and therapeutic context of DL-Pantothenyl alcohol

• Oral administration of pantothenol to mice infected with the murine parasite Plasmodium vinckei vinckei resulted in a significant inhibition of parasite proliferation [5].
• Graded single or fractionated dose irradiation (10 x 3 Gy/2 weeks, graded test doses on day 14) were combined with topical administration of dexpanthenol or a base, with or without Aloe vera extract [3].
• Dexpanthenol is popular in treating various dermatoses and in skin care, but few controlled clinical trials have been performed [9].
• Development and validation of reversed phase high performance liquid chromatography method for determination of dexpanthenol in pharmaceutical formulations [20].
• This paper describes the validation of an isocratic HPLC method for the assay of dexpanthenol in aerosol and gel [20].

References