The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

THTPA  -  thiamine triphosphatase

Homo sapiens

Synonyms: THTP, THTPASE, ThTPase, Thiamine-triphosphatase
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of THTPA

  • For this purpose, we expressed the untagged recombinant human ThTPase (hThTPase) in E. coli, produced the protein on a large scale and purified it to homogeneity [1].
 

High impact information on THTPA

 

Biological context of THTPA

 

Anatomical context of THTPA

  • The protein was rather uniformly located in the perikarya and dendrites, suggesting that ThTP and ThTPase may play a general role in neuronal metabolism rather than a specific role in excitability [7].
  • Some interneurons were also labeled and many ThTPase mRNA-positive and immunoreactive cells were distributed throughout cerebral cortical gray matter and the thalamus [7].
  • Thiamine triphosphatase (TTPase) from membranes isolated from the main electric organ of E. electricus is activated about 8 fold by NO3-, I- and SCN- while SO42- is inhibitory [8].
 

Associations of THTPA with chemical compounds

  • CONCLUSIONS: HAS rats have the genetically mediated thiamine diphosphate deficiency and increased thiamine triphosphate levels, probably due to reduced activity of thiamine triphosphatase in the liver and brain, compared with LAS rats [9].
  • A 6.4-fold increase in specific activity is obtained by successive treatment of crude membranes with octanoyl-N-methylglucamide, which solubilized other proteins, and Lubrol-PX with releases 60% of the thiamine triphosphatase (TTPase) activity [10].
 

Analytical, diagnostic and therapeutic context of THTPA

References

  1. Human recombinant thiamine triphosphatase: purification, secondary structure and catalytic properties. Lakaye, B., Makarchikov, A.F., Wins, P., Margineanu, I., Roland, S., Lins, L., Aichour, R., Lebeau, L., El Moualij, B., Zorzi, W., Coumans, B., Grisar, T., Bettendorff, L. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  2. Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals. Makarchikov, A.F., Lakaye, B., Gulyai, I.E., Czerniecki, J., Coumans, B., Wins, P., Grisar, T., Bettendorff, L. Cell. Mol. Life Sci. (2003) [Pubmed]
  3. Thiamine triphosphatase in the membranes of the main electric organ of Electrophorus electricus: substrate-enzyme interactions. Bettendorff, L., Grandfils, C., Wins, P., Schoffeniels, E. J. Neurochem. (1989) [Pubmed]
  4. Thiamine triphosphate and membrane-associated thiamine phosphatases in the electric organ of Electrophorus electricus. Bettendorff, L., Michel-Cahay, C., Grandfils, C., De Rycker, C., Schoffeniels, E. J. Neurochem. (1987) [Pubmed]
  5. Nonaromatic amidine derivatives as acylation catalysts. Birman, V.B., Li, X., Han, Z. Org. Lett. (2007) [Pubmed]
  6. The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates. Iyer, L.M., Aravind, L. BMC Genomics (2002) [Pubmed]
  7. Neuronal localization of the 25-kDa specific thiamine triphosphatase in rodent brain. Czerniecki, J., Chanas, G., Verlaet, M., Bettendorff, L., Makarchikov, A.F., Leprince, P., Wins, P., Grisar, T., Lakaye, B. Neuroscience (2004) [Pubmed]
  8. Thiamine triphosphatase from Electrophorus electric organ is anion-dependent and irreversibly inhibited by 4,4'-diisothiocyanostilbene-2,2'disulfonic acid. Bettendorff, L., Wins, P., Schoffeniels, E. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  9. Thiamine status in liver and brain of rats genetically selected for different sensitivity to hypnotic effect of alcohol. Zimatkina, T.I., Chernikevich, I.P., Zimatkin, S.M., Deitrich, R.A. Alcohol. Clin. Exp. Res. (2000) [Pubmed]
  10. Solubilization of thiamine triphosphatase from the electric organ of Electrophorus electricus. Bettendorff, L., Longrée, I., Wins, P., Schoffeniels, E. Biochim. Biophys. Acta (1991) [Pubmed]
 
WikiGenes - Universities