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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Galnt1  -  polypeptide N-acetylgalactosaminyltransfer...

Rattus norvegicus

Synonyms: GalNAc-T1, Polypeptide GalNAc transferase 1, Polypeptide N-acetylgalactosaminyltransferase 1, Protein-UDP acetylgalactosaminyltransferase 1, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1, ...
 
 
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High impact information on Galnt1

  • A comparison of serine and threonine O-glycosylation by UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase [1].
  • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase was derived from rat parotid, submandibular, and sublingual glands, liver and kidney as well as from human colostrum [1].
  • These results indicate that the lectin domain of GalNAc-T1 has at least two functional repeats, allowing the possibility of multivalent interactions with GalNAc residues on the acceptor polypeptide during glycosylation [2].
  • For the functional analysis of the cysteine residues, several conserved cysteine residues in GalNAc-T1 were mutated individually to alanine [3].
  • This suggests that GalNAc-T1 contains free cysteine residues interacting with the UDP moiety of the sugar donor [3].
 

Biological context of Galnt1

 

Associations of Galnt1 with chemical compounds

 

Analytical, diagnostic and therapeutic context of Galnt1

  • In this report, we studied the function of the beta and gamma repeats in the GalNAc-T1 lectin domain, by site-directed mutagenesis and analysis of the catalytic properties of mutant enzymes [2].

References

  1. A comparison of serine and threonine O-glycosylation by UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase. O'Connell, B.C., Tabak, L.A. J. Dent. Res. (1993) [Pubmed]
  2. Function of the lectin domain of polypeptide N-acetylgalactosaminyltransferase 1. Tenno, M., Kézdy, F.J., Elhammer, A.P., Kurosaka, A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  3. Identification of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1). Tenno, M., Toba, S., Kézdy, F.J., Elhammer, A.P., Kurosaka, A. Eur. J. Biochem. (2002) [Pubmed]
  4. Cloning and sequence homology of a rat UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase. Hagen, F.K., Gregoire, C.A., Tabak, L.A. Glycoconj. J. (1995) [Pubmed]
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