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Disease relevance of Colostrum


Psychiatry related information on Colostrum

  • Colostrinin: a proline-rich polypeptide (PRP) complex isolated from ovine colostrum for treatment of Alzheimer's disease. A double-blind, placebo-controlled study [6].

High impact information on Colostrum

  • Oligomeric, J-chain-containing immunoglobulins were observed to be transferred selectively from serum into colostrum [7].
  • Fat globule membranes have been isolated from bovine colostrum and bovine milk by the dispersion of the fat in sucrose solutions at 4 degrees C and fractionation by centrifugation through discontinuous sucrose gradients [8].
  • Colostrum and milk are rich sources of the vitamin and supply the nursing pig with ascorbic acid [9].
  • Heterogeneous molecular forms of apelin corresponding to apelin-36 and [<Glu(65)]apelin-13 were produced in bovine colostrum [10].
  • To determine the shortest motif sequence required for high level mucin-type O-glycosylation, we prepared more than 100 synthetic peptides and assayed in vitro O-GalNAc transfer to serine or threonine in these peptides using a bovine colostrum UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyl transferase (O-GalNAcT) [11].

Chemical compound and disease context of Colostrum


Biological context of Colostrum

  • Bovine beta 2-microglobulin (beta 2-m), the light chain of the histocompatibility antigen, was isolated in crystalline form from colostrum [16].
  • NH2-terminal amino acid sequence obtained from a UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase (GalNAc-transferase) isolated from bovine colostrum was used for the construction of synthetic oligonucleotide primers [17].
  • The decrease in the long-chain PUFA content observed from colostrum to mature milk and the concomitant occurrence of a precursor-product relationship between the linoleate and its long-chain PUFA are consistent with the mobilization of a preformed long-chain PUFA pool during early lactation [18].
  • PLP concentrations in cord blood and maternal plasma at 2 d postpartum and vitamin B-6 concentration in colostrum were positively correlated with the amount of PN.HCl supplementation prenatally (r = 0.71, p less than 0.001; r = 0.74, p less than 0.001; and r = 0.78, p less than 0.001, respectively) [19].
  • Only native and conformationally intact lactoferrin from bovine or human milk, colostrum, or serum could completely block HCMV infection (IC50 = 35-100 micrograms/mL) [20].

Anatomical context of Colostrum

  • In the infants with CMA (n = 96-100), the concentration of TGF-beta1 in colostrum was positively correlated with IgA antibodies to beta-lactoglobulin and IgG antibodies to alpha-casein and whole formula and negatively with the diameter of a skin prick test response to CM and lymphocyte stimulation indices to alpha-casein and beta-lactoglobulin [21].
  • Control proteins included purified secretory immunoglobulin A (sIgA) from human colostrum, human milk lactoferrin, and chicken-egg lysozyme [22].
  • A secretory immune response (manifested by the presence of specific IgA antibody to S. mutans in colostrum and milk) was elicited (i) in rat dams locally injected, in the region of the mammary gland, with heat-killed S. mutans antigen, and (ii) in other rat dams that were provided formalin-killed S. mutans in their drinking water [23].
  • Here, we demonstrate that CD15+ colostrum neutrophils express IgA Fc receptors (Fc alphaR, CD89) at levels similar to those of blood neutrophils [24].
  • Maternal vaccination with polyvalent pneumococcal polysaccharide vaccine boosts the capacity of colostrum to inhibit adherence of pneumococci to pharyngeal epithelial cells [25].

Associations of Colostrum with chemical compounds

  • Furthermore, allotypic differences of C3 between mother and fetus or neonates provide evidence that murine C3 is synthesized by fetus or neonate and is not transferred from mother transplacentally nor via colostrum [26].
  • A proline-rich protein has been isolated from sheep colostrum [27].
  • Treatments with endo-beta-N-acetylglucosaminidase H and F indicate that the colostrum enzyme is a glycoprotein containing two N-linked oligosaccharides [1].
  • In synthetic peptides the bovine colostrum GalNAc-transferase glycosylates threonine about 35 times faster than serine [28].
  • Occurrence of N-acetylglucosamine 6-phosphate in complex carbohydrates. Characterization of a phosphorylated sialyl oligosaccharide from bovine colostrum [29].

Gene context of Colostrum

  • The concentrations of IL-6, IL-10, and transforming growth factor-beta, which are all involved in IgA synthesis, correlated with each other and with total IgA concentrations in colostrum [30].
  • The concentrations of IL-4 were higher in colostrum from allergic than nonallergic mothers, and similar trends were seen for IL-5 and IL-13 [30].
  • On the other hand, most of the IGF I, but not IGF II, in day 1 colostrum appears to stem from the maternal circulation [31].
  • The pronounced differences between the IGFBP patterns of colostrum and early maternal serum suggest that IGFBP-2 does not pass from maternal blood into colostrum but is produced and secreted by mammary tissue itself [31].
  • Hepatic IGF-I mRNA levels and plasma IGF-I concentrations in veal calves, fattened castrated bulls and in intact bulls were 4 to 8 times higher than in 8-d old calves and were 2 to 3 times higher in calves fed colostrum than in calves fed only milk replacer [32].

Analytical, diagnostic and therapeutic context of Colostrum


  1. Purification and characterization of UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase from bovine colostrum and murine lymphoma BW5147 cells. Elhammer, A., Kornfeld, S. J. Biol. Chem. (1986) [Pubmed]
  2. Bacteriostatic effect of human milk and bovine colostrum on Escherichia coli: importance of bicarbonate. Griffiths, E., Humphreys, J. Infect. Immun. (1977) [Pubmed]
  3. Passive immunity in calf diarrhea: vaccination with K99 antigen of enterotoxigenic Escherichia coli and rotavirus. Snodgrass, D.R., Nagy, L.K., Sherwood, D., Campbell, I. Infect. Immun. (1982) [Pubmed]
  4. Elevated levels of bile acids in colostrum of patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy [see comemnts]. Brites, D., Rodrigues, C.M. J. Hepatol. (1998) [Pubmed]
  5. Inhibition of Helicobacter pylori and Helicobacter mustelae binding to lipid receptors by bovine colostrum. Bitzan, M.M., Gold, B.D., Philpott, D.J., Huesca, M., Sherman, P.M., Karch, H., Lissner, R., Lingwood, C.A., Karmali, M.A. J. Infect. Dis. (1998) [Pubmed]
  6. Colostrinin: a proline-rich polypeptide (PRP) complex isolated from ovine colostrum for treatment of Alzheimer's disease. A double-blind, placebo-controlled study. Leszek, J., Inglot, A.D., Janusz, M., Lisowski, J., Krukowska, K., Georgiades, J.A. Arch. Immunol. Ther. Exp. (Warsz.) (1999) [Pubmed]
  7. Transport of immunoglobulins from serum into colostrum. Halsey, J.F., Johnson, B.H., Cebra, J.J. J. Exp. Med. (1980) [Pubmed]
  8. Enzymic characteristics of fat globule membranes from bovine colostrum and bovine milk. Powell, J.T., Järlfors, U., Brew, K. J. Cell Biol. (1977) [Pubmed]
  9. Developmental aspects and factors influencing the synthesis and status of ascorbic Acid in the pig. Mahan, D.C., Ching, S., Dabrowski, K. Annu. Rev. Nutr. (2004) [Pubmed]
  10. Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. Hosoya, M., Kawamata, Y., Fukusumi, S., Fujii, R., Habata, Y., Hinuma, S., Kitada, C., Honda, S., Kurokawa, T., Onda, H., Nishimura, O., Fujino, M. J. Biol. Chem. (2000) [Pubmed]
  11. Discovery of the shortest sequence motif for high level mucin-type O-glycosylation. Yoshida, A., Suzuki, M., Ikenaga, H., Takeuchi, M. J. Biol. Chem. (1997) [Pubmed]
  12. Use of the 'nutriceutical', bovine colostrum, for the treatment of distal colitis: results from an initial study. Khan, Z., Macdonald, C., Wicks, A.C., Holt, M.P., Floyd, D., Ghosh, S., Wright, N.A., Playford, R.J. Aliment. Pharmacol. Ther. (2002) [Pubmed]
  13. Generation of bovine immune colostrum against Streptococcus mutans and Streptococcus sobrinus and its effect on glucose uptake and extracellular polysaccharide formation by mutans streptococci. Loimaranta, V., Tenovuo, J., Virtanen, S., Marnila, P., Syväoja, E.L., Tupasela, T., Korhonen, H. Vaccine (1997) [Pubmed]
  14. Human colostrum contains an activity that inhibits the production of IL-2. Hooton, J.W., Pabst, H.F., Spady, D.W., Paetkau, V. Clin. Exp. Immunol. (1991) [Pubmed]
  15. Progesterone antagonist (RU 486) for cervical dilation, labor induction, and delivery in monkeys: effectiveness in combination with oxytocin. Wolf, J.P., Sinosich, M., Anderson, T.L., Ulmann, A., Baulieu, E.E., Hodgen, G.D. Am. J. Obstet. Gynecol. (1989) [Pubmed]
  16. Solution physicochemical properties of bovine beta 2-microglobulin. Aggregation states. Kumosinski, T.F., Brown, E.M., Groves, M.L. J. Biol. Chem. (1981) [Pubmed]
  17. Isolation and expression of a cDNA clone encoding a bovine UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase. Homa, F.L., Hollander, T., Lehman, D.J., Thomsen, D.R., Elhammer, A.P. J. Biol. Chem. (1993) [Pubmed]
  18. Dependence of human milk essential fatty acids on adipose stores during lactation. Martin, J.C., Bougnoux, P., Fignon, A., Theret, V., Antoine, J.M., Lamisse, F., Couet, C. Am. J. Clin. Nutr. (1993) [Pubmed]
  19. Pyridoxine supplementation of lactating mothers: relation to maternal nutrition status and vitamin B-6 concentrations in milk. Chang, S.J., Kirksey, A. Am. J. Clin. Nutr. (1990) [Pubmed]
  20. Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. Harmsen, M.C., Swart, P.J., de Béthune, M.P., Pauwels, R., De Clercq, E., The, T.H., Meijer, D.K. J. Infect. Dis. (1995) [Pubmed]
  21. Transforming growth factor-beta1 in mothers' colostrum and immune responses to cows' milk proteins in infants with cows' milk allergy. Saarinen, K.M., Vaarala, O., Klemetti, P., Savilahti, E. J. Allergy Clin. Immunol. (1999) [Pubmed]
  22. Identification of lectin binding proteins in human tears. Kuizenga, A., van Haeringen, N.J., Kijlstra, A. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  23. Effective immunity to dental caries: passive transfer to rats to antibodies to Streptococcus mutans elicits protection. Michalek, S.M., McGhee, J.R. Infect. Immun. (1977) [Pubmed]
  24. Colostral neutrophils express Fc alpha receptors (CD89) lacking gamma chain association and mediate noninflammatory properties of secretory IgA. Honorio-França, A.C., Launay, P., Carneiro-Sampaio, M.M., Monteiro, R.C. J. Leukoc. Biol. (2001) [Pubmed]
  25. Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae. Deubzer, H.E., Obaro, S.K., Newman, V.O., Adegbola, R.A., Greenwood, B.M., Henderson, D.C. J. Infect. Dis. (2004) [Pubmed]
  26. The expression of the allelic gene of murine C3 in fetal and neonatal mice. Amano, S., Natsuume-Sakai, S., Hayakawa, J.I., Takahashi, M. J. Immunol. (1979) [Pubmed]
  27. A colostral protein that induces the growth and differentiation of resting B lymphocytes. Julius, M.H., Janusz, M., Lisowski, J. J. Immunol. (1988) [Pubmed]
  28. The specificity of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase as inferred from a database of in vivo substrates and from the in vitro glycosylation of proteins and peptides. Elhammer, A.P., Poorman, R.A., Brown, E., Maggiora, L.L., Hoogerheide, J.G., Kézdy, F.J. J. Biol. Chem. (1993) [Pubmed]
  29. Occurrence of N-acetylglucosamine 6-phosphate in complex carbohydrates. Characterization of a phosphorylated sialyl oligosaccharide from bovine colostrum. Parkkinen, J., Finne, J. J. Biol. Chem. (1985) [Pubmed]
  30. Cytokines in breast milk from allergic and nonallergic mothers. Böttcher, M.F., Jenmalm, M.C., Garofalo, R.P., Björkstén, B. Pediatr. Res. (2000) [Pubmed]
  31. Insulin-like growth factors (IGF) I and II and IGF binding proteins (IGFBPs) in human colostrum/transitory milk during the first week postpartum: comparison with neonatal and maternal serum. Eriksson, U., Duc, G., Froesch, E.R., Zapf, J. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  32. mRNA of insulin-like growth factor (IGF) quantification and presence of IGF binding proteins, and receptors for growth hormone, IGF-I and insulin, determined by reverse transcribed polymerase chain reaction, in the liver of growing and mature male cattle. Cordano, P., Hammon, H.M., Morel, C., Zurbriggen, A., Blum, J.W. Domest. Anim. Endocrinol. (2000) [Pubmed]
  33. Maternal and neonatal somatomedin C/insulin-like growth factor-I (IGF-I) and IGF binding proteins during early lactation in the pig. Simmen, F.A., Simmen, R.C., Reinhart, G. Dev. Biol. (1988) [Pubmed]
  34. Purification and partial sequence analysis of insulin-like growth factor-1 from bovine colostrum. Francis, G.L., Read, L.C., Ballard, F.J., Bagley, C.J., Upton, F.M., Gravestock, P.M., Wallace, J.C. Biochem. J. (1986) [Pubmed]
  35. Chemoattractant factors in breast milk from allergic and nonallergic mothers. Böttcher, M.F., Jenmalm, M.C., Björkstén, B., Garofalo, R.P. Pediatr. Res. (2000) [Pubmed]
  36. Prostaglandins in human milk. Reid, B., Smith, H., Friedman, Z. Pediatrics (1980) [Pubmed]
  37. Sequential changes in the antimicrobial protein concentrations in human milk during lactation and its relevance to banked human milk. Lewis-Jones, D.I., Lewis-Jones, M.S., Connolly, R.C., Lloyd, D.C., West, C.R. Pediatr. Res. (1985) [Pubmed]
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