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Gene Review

GALNT1  -  polypeptide N-acetylgalactosaminyltransfer...

Homo sapiens

Synonyms: GalNAc-T1, Polypeptide GalNAc transferase 1, Polypeptide N-acetylgalactosaminyltransferase 1, Protein-UDP acetylgalactosaminyltransferase 1, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1, ...
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Disease relevance of GALNT1


High impact information on GALNT1


Biological context of GALNT1


Anatomical context of GALNT1


Associations of GALNT1 with chemical compounds


Other interactions of GALNT1


Analytical, diagnostic and therapeutic context of GALNT1


  1. N-acetylgalactosamine glycosylation of MUC1 tandem repeat peptides by pancreatic tumor cell extracts. Nishimori, I., Perini, F., Mountjoy, K.P., Sanderson, S.D., Johnson, N., Cerny, R.L., Gross, M.L., Fontenot, J.D., Hollingsworth, M.A. Cancer Res. (1994) [Pubmed]
  2. Ganglioside GM2/GD2 synthetase mRNA is a marker for detection of infrequent neuroblastoma cells in bone marrow. Hoon, D.S., Kuo, C.T., Wen, S., Wang, H., Metelitsa, L., Reynolds, C.P., Seeger, R.C. Am. J. Pathol. (2001) [Pubmed]
  3. Increased sensitivity of gastric cancer cells to natural killer and lymphokine-activated killer cells by antisense suppression of N-acetylgalactosaminyltransferase. Adachi, T., Hinoda, Y., Nishimori, I., Adachi, M., Imai, K. J. Immunol. (1997) [Pubmed]
  4. Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation. Kato, K., Jeanneau, C., Tarp, M.A., Benet-Pagès, A., Lorenz-Depiereux, B., Bennett, E.P., Mandel, U., Strom, T.M., Clausen, H. J. Biol. Chem. (2006) [Pubmed]
  5. Molecular cloning of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T8, and analysis as a candidate autosomal dominant hypophosphatemic rickets (ADHR) gene. White, K.E., Lorenz, B., Evans, W.E., Meitinger, T., Strom, T.M., Econs, M.J. Gene (2000) [Pubmed]
  6. Association of circulating tumor cells with serum tumor-related methylated DNA in peripheral blood of melanoma patients. Koyanagi, K., Mori, T., O'Day, S.J., Martinez, S.R., Wang, H.J., Hoon, D.S. Cancer Res. (2006) [Pubmed]
  7. Expression of three UDP-N-acetyl-alpha-D-galactosamine:polypeptide GalNAc N-acetylgalactosaminyltransferases in adenocarcinoma cell lines. Sutherlin, M.E., Nishimori, I., Caffrey, T., Bennett, E.P., Hassan, H., Mandel, U., Mack, D., Iwamura, T., Clausen, H., Hollingsworth, M.A. Cancer Res. (1997) [Pubmed]
  8. Structure-based design of beta 1,4-galactosyltransferase I (beta 4Gal-T1) with equally efficient N-acetylgalactosaminyltransferase activity: point mutation broadens beta 4Gal-T1 donor specificity. Ramakrishnan, B., Qasba, P.K. J. Biol. Chem. (2002) [Pubmed]
  9. Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy. Bennett, E.P., Hassan, H., Mandel, U., Hollingsworth, M.A., Akisawa, N., Ikematsu, Y., Merkx, G., van Kessel, A.G., Olofsson, S., Clausen, H. J. Biol. Chem. (1999) [Pubmed]
  10. Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family. Bennett, E.P., Weghuis, D.O., Merkx, G., van Kessel, A.G., Eiberg, H., Clausen, H. Glycobiology (1998) [Pubmed]
  11. Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3. Wandall, H.H., Hassan, H., Mirgorodskaya, E., Kristensen, A.K., Roepstorff, P., Bennett, E.P., Nielsen, P.A., Hollingsworth, M.A., Burchell, J., Taylor-Papadimitriou, J., Clausen, H. J. Biol. Chem. (1997) [Pubmed]
  12. Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus. Röttger, S., White, J., Wandall, H.H., Olivo, J.C., Stark, A., Bennett, E.P., Whitehouse, C., Berger, E.G., Clausen, H., Nilsson, T. J. Cell. Sci. (1998) [Pubmed]
  13. cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3. Bennett, E.P., Hassan, H., Clausen, H. J. Biol. Chem. (1996) [Pubmed]
  14. The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization. Argüeso, P., Tisdale, A., Mandel, U., Letko, E., Foster, C.S., Gipson, I.K. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  15. Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas: immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family. Mandel, U., Hassan, H., Therkildsen, M.H., Rygaard, J., Jakobsen, M.H., Juhl, B.R., Dabelsteen, E., Clausen, H. Glycobiology (1999) [Pubmed]
  16. Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines. Marcos, N.T., Cruz, A., Silva, F., Almeida, R., David, L., Mandel, U., Clausen, H., Von Mensdorff-Pouilly, S., Reis, C.A. J. Histochem. Cytochem. (2003) [Pubmed]
  17. Cloned beta 1,4 N-acetylgalactosaminyltransferase synthesizes GA2 as well as gangliosides GM2 and GD2. GM3 synthesis has priority over GA2 synthesis for utilization of lactosylceramide substrate in vivo. Lutz, M.S., Jaskiewicz, E., Darling, D.S., Furukawa, K., Young, W.W. J. Biol. Chem. (1994) [Pubmed]
  18. Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat. Bennett, E.P., Hassan, H., Mandel, U., Mirgorodskaya, E., Roepstorff, P., Burchell, J., Taylor-Papadimitriou, J., Hollingsworth, M.A., Merkx, G., van Kessel, A.G., Eiberg, H., Steffensen, R., Clausen, H. J. Biol. Chem. (1998) [Pubmed]
  19. Sequence-variant repeats of MUC1 show higher conformational flexibility, are less densely O-glycosylated and induce differential B lymphocyte responses. von Mensdorff-Pouilly, S., Kinarsky, L., Engelmann, K., Baldus, S.E., Verheijen, R.H., Hollingsworth, M.A., Pisarev, V., Sherman, S., Hanisch, F.G. Glycobiology (2005) [Pubmed]
  20. The acceptor substrate specificity of porcine submaxillary UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is dependent on the amino acid sequences adjacent to serine and threonine residues. Wang, Y., Agrwal, N., Eckhardt, A.E., Stevens, R.D., Hill, R.L. J. Biol. Chem. (1993) [Pubmed]
  21. GA2/GM2/GD2 synthase localizes to the trans-golgi network of CHO-K1 cells. Giraudo, C.G., Rosales Fritz, V.M., Maccioni, H.J. Biochem. J. (1999) [Pubmed]
  22. Expression in human ocular surface tissues of the GalNAc-transferases that initiate mucin-type O-glycosylation. Imbert, Y., Jumblatt, M.M., Foulks, G.N., Couzin, E.G., Steele, P.S., Young, W.W. Cornea (2006) [Pubmed]
  23. Regulation of sialomucin production in colon carcinoma cells. Dohi, D.F., Sutton, R.C., Frazier, M.L., Nakamori, S., McIsaac, A.M., Irimura, T. J. Biol. Chem. (1993) [Pubmed]
  24. Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14. Wang, H., Tachibana, K., Zhang, Y., Iwasaki, H., Kameyama, A., Cheng, L., Guo, J., Hiruma, T., Togayachi, A., Kudo, T., Kikuchi, N., Narimatsu, H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  25. A human UDP-GalNAc: polypeptide, N-acetylgalactosaminyltransferase type 1 gene is located at the chromosomal region 18q12.1. Takai, S., Hinoda, Y., Adachi, T., Imai, K., Oshima, M. Hum. Genet. (1997) [Pubmed]
  26. Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12. Guo, J.M., Zhang, Y., Cheng, L., Iwasaki, H., Wang, H., Kubota, T., Tachibana, K., Narimatsu, H. FEBS Lett. (2002) [Pubmed]
  27. Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase from swine trachea epithelium. Mendicino, J., Sangadala, S. Mol. Cell. Biochem. (1998) [Pubmed]
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