The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HAUS3  -  HAUS augmin-like complex, subunit 3

Homo sapiens

Synonyms: C4orf15, HAUS augmin-like complex subunit 3, IT1, MGC4701, dgt3
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C4orf15

  • Sera from humans vaccinated with a high-molecular-weight polysaccharide vaccine to Pseudomonas aeruginosa immunotype 1 (IT-1) were analyzed for duration of the immune response, specificity for the IT-1 determinant, and by assessing the immunoglobulin classes elicited [1].
  • According to the results of the toxicity test as well as the amino acid composition and N-terminal analyses, BmK IT1 is the excitatory insect neurotoxin as reported in a previous paper, and the others are the newly found depressant insect-selective neurotoxins [2].

High impact information on C4orf15

  • The concentration of antibodies to IT-1 LPS was 7.6 micrograms/ml in PA-IGIV and 478 micrograms/ml in the IT-1 MAb preparation [3].
  • IT3, consisting of a symmetrical dimethyl-substituted disulfide bond, was substantially more stable in vivo (t1/2 beta = 88.3 h) than the corresponding IT2, characterized by a disulfide-protected monomethyl substituent bond (t1/2 beta = 60.2 h) compared to the unhindered conjugate IT1 (t1/2 beta = 27.9 h) [4].
  • The excitatory toxin Lqq IT1 and Lqq IT1' (70 residues) show the shift of one half-cystine from an external position, which is characteristic of anti-mammal toxins, to an internal sequence position [5].
  • The cDNA deduced sequence of this toxin was homologous with the determined amino acid sequence of BmK IT1, an excitatory insect toxin purified from the scorpion venom, except for three different residues, two at the positions 24-25, and another in the COOH-terminus of the toxin [6].

Analytical, diagnostic and therapeutic context of C4orf15

  • 3) The slow lethal factor is composed of two toxins (IT1 and IT2), the purity of which was assessed by column chromatography, disc electrophoresis, isoelectrofocusing, analytical ultracentrifugation, and amino acid analyses [7].
  • For study, animals were infected by intratracheal instillation of IT-1 P. aeruginosa and then treated 2 h later with intravenous infusions of PA-IGIV, IT-1 MAb, or porin MAb [3].
  • The molecular weights of IT1, IT2 and IT3, determined by HPLC gel filtration chromatography, were 220 kD, 59 kD and 67 kD, respectively [8].


  1. Characterization of the human immune response to a polysaccharide vaccine from Pseudomonas aeruginosa. Pier, G.B., Thomas, D.M. J. Infect. Dis. (1983) [Pubmed]
  2. Molecular characteristics of four new depressant insect neurotoxins purified from venom of Buthus martensi Karsch by HPLC. Ji, Y.H., Hattori, H., Xu, K., Terakawa, S. Sci. China, Ser. B, Chem. Life Sci. Earth Sci. (1994) [Pubmed]
  3. Polyclonal and monoclonal antibody therapy for experimental Pseudomonas aeruginosa pneumonia. Pennington, J.E., Small, G.J., Lostrom, M.E., Pier, G.B. Infect. Immun. (1986) [Pubmed]
  4. New coupling reagents for the preparation of disulfide cross-linked conjugates with increased stability. Arpicco, S., Dosio, F., Brusa, P., Crosasso, P., Cattel, L. Bioconjug. Chem. (1997) [Pubmed]
  5. Primary structure of scorpion anti-insect toxins isolated from the venom of Leiurus quinquestriatus quinquestriatus. Kopeyan, C., Mansuelle, P., Sampieri, F., Brando, T., Bahraoui, E.M., Rochat, H., Granier, C. FEBS Lett. (1990) [Pubmed]
  6. The cDNA sequence of an excitatory insect selective neurotoxin from the scorpion Buthus martensi Karsch. Xiong, Y.M., Ling, M.H., Lan, Z.D., Wang, D.C., Chi, C.W. Toxicon (1999) [Pubmed]
  7. Insect toxic component from the venom of a chactoid scorpion, Scorpio maurus palmatus (Scorpionidae). Lazarovici, P., Yanai, P., Pelhate, M., Zlotkin, E. J. Biol. Chem. (1982) [Pubmed]
  8. Partial purification and characterization of soluble acid invertases from rice (Oryza sativa) leaves. Lin, S.S., Sung, H.Y. Biochem. Mol. Biol. Int. (1993) [Pubmed]
WikiGenes - Universities