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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DYNC2H1  -  dynein, cytoplasmic 2, heavy chain 1

Homo sapiens

Synonyms: ATD3, Cytoplasmic dynein 2 heavy chain, Cytoplasmic dynein 2 heavy chain 1, DHC1B, DHC1b, ...
 
 
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Psychiatry related information on DYNC2H1

  • Interestingly, the remaining DHC1b is normally distributed in the mutant flagella, strongly suggesting that the defect is in binding of cargo to the retrograde motor rather than in motor activity per se [1].
 

High impact information on DYNC2H1

  • Identification and characterization of new family members (in particular KIFC2, 16 new KIFs, XKlp2 and XKCM1 of the kinesin superfamily, and DHC2 and DHC3 of the dynein superfamily) and further characterization of known family members have improved our understanding of these cellular mechanisms [2].
  • DHC2 is a distant member of the "cytoplasmic" branch of the dynein phylogenetic tree, while DHC3 shares more sequence similarity with dynein-like polypeptides that have been thought to be axonemal [3].
  • DHC2 is localized predominantly to the Golgi apparatus [3].
  • D2LIC colocalizes with DHC2 at the Golgi apparatus throughout the cell cycle [4].
  • We mapped expressed tagged sequences (ESTs) corresponding to two human dynein heavy chain genes: beta heavy chain of the outer dynein arm and heavy chain isotype 1B (DYH1B), by using somatic cell hybrids and radiation hybrid panels [5].
 

Biological context of DYNC2H1

  • The EST for the beta heavy chain of the outer dynein arm mapped to chromosome region 7p15, and the EST for DYH1B mapped to 11q13 [5].
 

Physical interactions of DYNC2H1

 

Other interactions of DYNC2H1

 

Analytical, diagnostic and therapeutic context of DYNC2H1

  • Moreover, the Golgi disperses upon microinjection of antibodies to DHC2, suggesting that this motor is involved in establishing proper Golgi organization [3].
  • Indirect immunofluorescence microscopy revealed that DHC1b is not detected in cilia and remains in the cytoplasm of ciliated RTE cells, often accumulating at the apical ends of the cells [7].

References

  1. A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport. Hou, Y., Pazour, G.J., Witman, G.B. Mol. Biol. Cell (2004) [Pubmed]
  2. Kinesin and dynein superfamily proteins in organelle transport and cell division. Hirokawa, N., Noda, Y., Okada, Y. Curr. Opin. Cell Biol. (1998) [Pubmed]
  3. Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles. Vaisberg, E.A., Grissom, P.M., McIntosh, J.R. J. Cell Biol. (1996) [Pubmed]
  4. Identification of a novel light intermediate chain (D2LIC) for mammalian cytoplasmic dynein 2. Grissom, P.M., Vaisberg, E.A., McIntosh, J.R. Mol. Biol. Cell (2002) [Pubmed]
  5. Chromosomal mapping of two members of the human dynein gene family to chromosome regions 7p15 and 11q13 near the deafness loci DFNA 5 and DFNA 11. Kastury, K., Taylor, W.E., Gutierrez, M., Ramirez, L., Coucke, P.J., Van Hauwe, P., Van Camp, G., Bhasin, S. Genomics (1997) [Pubmed]
  6. Chromosomal localization of the human cytoplasmic dynein heavy chain gene DNCH2 to 11q21-->q22.1. Koehler, M.R., Schmid, M., Neesen, J. Cytogenet. Cell Genet. (1998) [Pubmed]
  7. A novel cytoplasmic dynein heavy chain: expression of DHC1b in mammalian ciliated epithelial cells. Criswell, P.S., Ostrowski, L.E., Asai, D.J. J. Cell. Sci. (1996) [Pubmed]
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