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Gene Review

DYNC1H1  -  dynein, cytoplasmic 1, heavy chain 1

Homo sapiens

Synonyms: Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein heavy chain 1, DHC1, DHC1a, DNCH1, ...
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Disease relevance of DYNC1H1


Psychiatry related information on DYNC1H1

  • We have found no chromosome rearrangement detectable with the methods used and no correlation between fra(X) (p22) and the Rett syndrome [6].

High impact information on DYNC1H1

  • We have cloned and expressed DNA fragments that encode the putative ATP-hydrolytic sites of the cytoplasmic dynein heavy chain from HeLa cells and from Dictyostelium [7].
  • A polyclonal antiserum prepared against the dynein heavy chains has been used to isolate dynein heavy chain (DYHC) cDNAs from a trout testis lambda gt11 cDNA expression library. beta-galactosidase fusion proteins produced in lambda gt11 by these trout cDNAs cross-reacted with a heterologous anti-sea urchin dynein antiserum [8].
  • All the DYHC cDNAs encode portions of a highly unusual DNA coding sequence comprised of 21 bp direct repeats [8].
  • The peptide sequences derived from the p22 subunit indicated that this subunit is identical to Cdm1, previously identified as a multicopy suppressor of the temperature-sensitive cdc1-P13 mutant, whereas peptide sequences derived from the p42 subunit were identical to a previously uncharacterized ORF located on S. pombe chromosome 1 [9].
  • It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerization, or else by binding cytoplasmic dynein heavy chain or microtubules directly [10].

Biological context of DYNC1H1


Anatomical context of DYNC1H1


Associations of DYNC1H1 with chemical compounds

  • Worms depleted for LIS1 pathway components (NUD-1, NUD-2, DHC-1, CDK-5, and CDKA-1) exhibited significant convulsions following PTZ and RNAi treatment [18].
  • This new more active ICE form serves both as an intermediate enzyme to cleave p45 as well as a substrate for the formation of the final active ICE (ED50 of 1 nM L-742,395 labeling of p20 and for p22, an NH2-terminally extended form of p20) [19].
  • In comparison, cimetidine had an IC50 value of 1.5 mM using microsomes from liver HL3 [20].
  • The oxidation of metoprolol by human liver microsomes was impaired by histamine (IC50 values for ODM appearance at 25 microM: liver HL1 greater than 10, HL3 = 3.8 and HL4 = 3.7 mM) [20].
  • [NEt4]2[Tc(CO)3Cl3] reacts with thiosemicarbazones derived from 2,2'-dipyridyl ketone (HL3) and 4-acetylpyridine (HL4) to form stable technetium(I) complexes of the compositions [Tc(CO)3Cl(HL3-Npy,Npy)] and [Tc2(CO)6Cl2(micro-HL4-Npy,S)] [21].

Physical interactions of DYNC1H1


Other interactions of DYNC1H1


Analytical, diagnostic and therapeutic context of DYNC1H1


  1. No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: a tagging SNP approach. Shah, P.R., Ahmad-Annuar, A., Ahmadi, K.R., Russ, C., Sapp, P.C., Horvitz, H.R., Brown, R.H., Goldstein, D.B., Fisher, E.M. Amyotroph. Lateral Scler. Other Motor Neuron Disord. (2006) [Pubmed]
  2. Establishment of two new myeloma cell lines from bilateral pleural effusions: evidence for sequential in vivo clonal change. Durie, B.G., Vela, E., Baum, V., Leibovitz, A., Payne, C.M., Richter, L.C., Grogan, T.M., Trent, J.M. Blood (1985) [Pubmed]
  3. Identification of a recurring translocation site involving chromosome 6 in human malignant melanoma. Trent, J.M., Thompson, F.H., Meyskens, F.L. Cancer Res. (1989) [Pubmed]
  4. DNA copy number changes in thyroid carcinoma. Hemmer, S., Wasenius, V.M., Knuutila, S., Franssila, K., Joensuu, H. Am. J. Pathol. (1999) [Pubmed]
  5. Structural proteins of hepatitis C virus. Miyamura, T., Matsuura, Y. Trends Microbiol. (1993) [Pubmed]
  6. In search of a genetic basis for the Rett syndrome. Martinho, P.S., Otto, P.G., Kok, F., Diament, A., Marques-Dias, M.J., Gonzalez, C.H. Hum. Genet. (1990) [Pubmed]
  7. Cytoplasmic dynein plays a role in mammalian mitotic spindle formation. Vaisberg, E.A., Koonce, M.P., McIntosh, J.R. J. Cell Biol. (1993) [Pubmed]
  8. Isolation of dynein heavy chain cDNAs from trout testis which predict an extensive carboxyl-terminal alpha-helical coiled-coil domain. Garber, A.T., Retief, J.D., Dixon, G.H. EMBO J. (1989) [Pubmed]
  9. DNA polymerase delta isolated from Schizosaccharomyces pombe contains five subunits. Zuo, S., Gibbs, E., Kelman, Z., Wang, T.S., O'Donnell, M., MacNeill, S.A., Hurwitz, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  10. A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration. Emes, R.D., Ponting, C.P. Hum. Mol. Genet. (2001) [Pubmed]
  11. The 14-kDa dynein light chain-family protein Dlc1 is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeast. Miki, F., Okazaki, K., Shimanuki, M., Yamamoto, A., Hiraoka, Y., Niwa, O. Mol. Biol. Cell (2002) [Pubmed]
  12. Identification of lamin B and histones as 1,25-dihydroxyvitamin D3-regulated nuclear phosphoproteins in HL-60 cells. Martell, R.E., Strahler, J.R., Simpson, R.U. J. Biol. Chem. (1992) [Pubmed]
  13. Antibodies to cytoplasmic dynein heavy chain map the surface and inhibit motility. Fan, J., Amos, L.A. J. Mol. Biol. (2001) [Pubmed]
  14. C242T polymorphism of NADPH oxidase p22 PHOX gene and ischemic cerebrovascular disease in the Japanese population. Ito, D., Murata, M., Watanabe, K., Yoshida, T., Saito, I., Tanahashi, N., Fukuuchi, Y. Stroke (2000) [Pubmed]
  15. Role of cytoplasmic dynein in melanosome transport in human melanocytes. Byers, H.R., Yaar, M., Eller, M.S., Jalbert, N.L., Gilchrest, B.A. J. Invest. Dermatol. (2000) [Pubmed]
  16. Effect of 1,25-dihydroxyvitamin D3, lipopolysaccharide, or lipoteichoic acid on the expression of NADPH oxidase components in cultured human monocytes. Levy, R., Malech, H.L. J. Immunol. (1991) [Pubmed]
  17. IL-1 beta-converting enzyme (ICE) is present and functional in human alveolar macrophages: macrophage IL-1 beta release limitation is ICE independent. Wewers, M.D., Dare, H.A., Winnard, A.V., Parker, J.M., Miller, D.K. J. Immunol. (1997) [Pubmed]
  18. Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Locke, C.J., Williams, S.N., Schwarz, E.M., Caldwell, G.A., Caldwell, K.A. Brain Res. (2006) [Pubmed]
  19. Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme. Yamin, T.T., Ayala, J.M., Miller, D.K. J. Biol. Chem. (1996) [Pubmed]
  20. Histamine inhibition of mixed function oxidase activity in rat and human liver microsomes and in the isolated perfused rat liver. Morris, C.Q., Tucker, G.T., Crewe, H.K., Harlow, J.R., Woods, H.F., Lennard, M.S. Biochem. Pharmacol. (1989) [Pubmed]
  21. Mono- and dinuclear tricarbonyltechnetium(I) complexes with thiosemicarbazones. Pereiras-Gabián, G., Vázquez-López, E.M., Braband, H., Abram, U. Inorganic chemistry. (2005) [Pubmed]
  22. The murine Dnali1 gene encodes a flagellar protein that interacts with the cytoplasmic dynein heavy chain 1. Rashid, S., Breckle, R., Hupe, M., Geisler, S., Doerwald, N., Neesen, J. Mol. Reprod. Dev. (2006) [Pubmed]
  23. Chromosomal localization of the human cytoplasmic dynein heavy chain gene DNCH2 to 11q21-->q22.1. Koehler, M.R., Schmid, M., Neesen, J. Cytogenet. Cell Genet. (1998) [Pubmed]
  24. Dynamic association of cytoplasmic dynein heavy chain 1a with the Golgi apparatus and intermediate compartment. Roghi, C., Allan, V.J. J. Cell. Sci. (1999) [Pubmed]
  25. Localization of the human cytoplasmic dynein heavy chain (DNECL) to 14qter by fluorescence in situ hybridization. Narayan, D., Desai, T., Banks, A., Patanjali, S.R., Ravikumar, T.S., Ward, D.C. Genomics (1994) [Pubmed]
  26. Protein antigens of Chlamydia psittaci present in infected cells but not detected in the infectious elementary body. Rockey, D.D., Rosquist, J.L. Infect. Immun. (1994) [Pubmed]
  27. Glycopeptide composition of hepatitis B surface antigen. Shiraishi, H., Shirachi, R., Akiyama, K., Ishida, N. J. Gen. Virol. (1980) [Pubmed]
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