Disease relevance of KCNH6

• RT-PCR analysis reveals that cervical squamous cell carcinoma (C-33A, MS-751 and QG-U), and endometrial adenocarcinoma (AN3-CA, KLE and Ishikawa), but not cervical adenocarcinoma (CAC-1 and OMC-4), expresses both or either one of the two human eag-related genes (HERG2 and 3, or KCNH6 and 7) [1].

High impact information on KCNH6

• The erg2 and erg3 genes are expressed exclusively in the nervous system, in marked contrast to erg1, which is expressed in both neural and non-neural tissues [2].
• ETS-1 protein is phosphorylated by Ca(2+)-dependent events, whereas ERG-2 protein is phosphorylated by activation of protein kinase C, suggesting their involvement in distinct signal transduction mechanisms [3].
• The expression of ERG-2 protein is restricted to few cell types and is high in early myeloid cells, indicating that it may function at an early stage of hematopoietic lineage determination [3].
• ERG-2 is a nuclear phosphoprotein and binds to purine-rich sequences (C/G)(C/a)GG-AA(G/a)T [3].
• Like other ets proteins, ERG-2 is a sequence-specific DNA-binding protein and is expressed at higher levels in early myeloid cells than in mature lymphoid cells [3].

Biological context of KCNH6

• Analysis of the sigma(1) protein sequence confirmed homologies with the ERG2/emopamil binding protein family but also with the steroidogenic enzymes isopentenyl diphosphate isomerase and 17beta-estradiol dehydrogenase [4].

Associations of KCNH6 with chemical compounds

• The influence of ERG on insulin secretion was monitored by perfusion of rat INS-1 beta-cells with the blockers E-4031 and rBeKm-1.We identified Erg1a, Erg1b, Erg2 and Erg3 transcripts in islets and INS-1 cells [5].

Other interactions of KCNH6

• For comparison, corresponding values were obtained for heterologously expressed rat erg1, erg2 and erg3 channels [6].
• The voltage dependence of activation was shifted by 15 mV (erg1), 10 mV (erg2) and 6 mV (erg3) to more positive potentials without strongly affecting erg inactivation [7].

Analytical, diagnostic and therapeutic context of KCNH6

• Immunohistochemistry was used to identify the pancreatic distribution patterns of ERG1a and ERG1b, as well as ERG2 and ERG3 [5].

References