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Gene Review

TMEM54  -  transmembrane protein 54

Homo sapiens

Synonyms: BCLP, Beta-casein-like protein, CAC-1, CAC1, Protein CAC-1, ...
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Disease relevance of TMEM54

  • One of eight new monoclonal antibodies generated, 12G2, specifically reacted not only with beta-casein, but also with human cervical adenocarcinoma cell line CAC-1 [1].
  • The microbial degradation of chlorinated and nonchlorinated methanes, ethanes, and ethanes by a mixed methane-oxidizing culture grown under chemostat and batch conditions is evaluated and compared with that by two pure methanotrophic strains: CAC1 (isolated from the mixed culture) and Methylosinus trichosporium OB3b [2].
  • RT-PCR analysis reveals that cervical squamous cell carcinoma (C-33A, MS-751 and QG-U), and endometrial adenocarcinoma (AN3-CA, KLE and Ishikawa), but not cervical adenocarcinoma (CAC-1 and OMC-4), expresses both or either one of the two human eag-related genes (HERG2 and 3, or KCNH6 and 7) [3].
  • The subjects were 260 (108 girls, 152 boys) 6-yr-old Finnish-speaking non-syndromic children with isolated cleft palate (CP, n = 79), cleft lip/alveolus (CL(A), n = 76), unilateral (UCLP, n = 78), and bilateral (BCLP, n = 27) cleft lip and palate [4].
  • Sixty per cent of primary MLSs and 57% of secondary lymphomas were reactive for BCLP [5].

High impact information on TMEM54


Biological context of TMEM54

  • To identify the gene encoding the putative protein (BCLP) defined by monoclonal antibody (mAb) 12G2, a complementary DNA library was constructed [1].
  • A slight lag in cell growth was observed when CAC-1 cells were treated with 1 microM 13-cis or all-trans retinoic acid during a 12-day growth curve [9].
  • The B-cell leukemia/lymphoma gene (bcl-2) produces a unique protein product (BCLP) that is believed to protect lymphoid cells from apoptosis [5].
  • Gonial angle shows sex differences for BCLP only [10].
  • Injection of Bclp causes the same cytoxic effects and alterations of the cuticule as those observed during mycosis, and may contribute to the virulence of strain 618 [11].

Anatomical context of TMEM54

  • CAC-1 cells exhibited a similar response because they also organized actin filaments and enlarged in response to retinoic acid treatment [9].
  • Differences in growth velocities were compared with those of 25 children with UCLP and 15 children with BCLP with delayed closure of hard palate (12 to 14 months) [12].
  • The aim of this study was to describe maxillary and mandibular dental-arch form and occlusion in bilateral cleft of the lip and palate (BCLP) from 3 to 17 years of age and to compare their characteristics with a normative sample [13].
  • The posterior height of the maxilla is significantly shorter in patients both with UCLP and BCLP at T(0) and T(1) [14].
  • In boys with BCLP, the highest retardation of eruption was found in the permanent maxillary lateral incisor and in the permanent maxillary first molar [15].

Associations of TMEM54 with chemical compounds

  • For first structure-activity-relationship studies modifications at various positions of the etacrynic acid structure have been investigated concerning inhibition potency against the CAC1 protease papain: length of the side chain, substitution pattern of the aromatic ring as well as influence and necessity of acidic groups, esters or amides [16].

Analytical, diagnostic and therapeutic context of TMEM54

  • No significant differences were found between right and left nostrils within the BCLP patients and between them and the control group [17].
  • Four patients needed surgical correction of conditions that should be considered complications resulting from the osteotomy, including a case of partial ischaemic necrosis of the premaxilla in a BCLP patient [18].
  • AIMS AND METHODS: Twelve UCLP and eleven BCLP patients who had been treated according to the Hanover treatment protocol were evaluated by means of cephalometric analysis and cast measurements [19].
  • METHODS: Nine complete cleft lip and palate patients (8 UCLP, 1 BCLP) at least 6 months post secondary alveolar bone grafting were selected [20].
  • The following material was studied: lateral head X-rays and plaster casts from 146 patients with unilateral (UCLP) and bilateral (BCLP) clefts of lip and palate from birth to 16 years of age [21].


  1. Cloning and characterization of a cDNA fragment coding beta-casein-like protein preferentially expressed in cervical adenocarcinoma cell line CAC-1. Suzuki, T., Koizumi, M., Baba, T., Kudo, R. Cancer Lett. (1998) [Pubmed]
  2. Biodegradation of individual and multiple chlorinated aliphatic hydrocarbons by methane-oxidizing cultures. Chang, H.L., Alvarez-Cohen, L. Appl. Environ. Microbiol. (1996) [Pubmed]
  3. Selective expression of HERG and Kv2 channels influences proliferation of uterine cancer cells. Suzuki, T., Takimoto, K. Int. J. Oncol. (2004) [Pubmed]
  4. Associations between dental occlusion and misarticulations of Finnish dental consonants in cleft lip/palate children. Laitinen, J., Ranta, R., Pulkkinen, J., Haapanen, M.L. Eur. J. Oral Sci. (1999) [Pubmed]
  5. Immunoreactivity for bcl-2 protein in cutaneous lymphomas and lymphoid hyperplasias. Triscott, J.A., Ritter, J.H., Swanson, P.E., Wick, M.R. J. Cutan. Pathol. (1995) [Pubmed]
  6. Epidermal growth factor increased the expression of alpha2beta1-integrin and modulated integrin-mediated signaling in human cervical adenocarcinoma cells. Yamanaka, I., Koizumi, M., Baba, T., Yamashita, S., Suzuki, T., Kudo, R. Exp. Cell Res. (2003) [Pubmed]
  7. cAMP-pKA signaling regulates multiple steps of fungal infection cooperatively with Cmk1 MAP kinase in Colletotrichum lagenarium. Yamauchi, J., Takayanagi, N., Komeda, K., Takano, Y., Okuno, T. Mol. Plant Microbe Interact. (2004) [Pubmed]
  8. Cloning and characterization of a tumor-associated antigen, beta-casein-like protein. Baba, T., Koizumi, M., Suzuki, T., Yamanaka, I., Yamashita, S., Kudo, R. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  9. A newly characterized human endometrial adenocarcinoma cell line (CAC-1) differentiates in response to retinoic acid treatment. Carter, C.A., Madden, V.J. Exp. Mol. Pathol. (2000) [Pubmed]
  10. Cleft type and sex differences in craniofacial growth in clefting from one month to ten years. Jain, R.B., Krogman, W.M. The Cleft palate journal. (1983) [Pubmed]
  11. Production in vitro of toxic macromolecules by strains of Beauveria bassiana, and purification of a chitosanase-like protein secreted by a melanizing isolate. Fuguet, R., Théraud, M., Vey, A. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2004) [Pubmed]
  12. Influence of early hard palate closure in unilateral and bilateral cleft lip and palate on maxillary transverse growth during the first four years of age. Lehner, B., Wiltfang, J., Strobel-Schwarthoff, K., Benz, M., Hirschfelder, U., Neukam, F.W. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. (2003) [Pubmed]
  13. Maxillary and mandibular dental-arch dimensions and occlusion in bilateral cleft lip and palate patients form 3 to 17 years of age. Heidbuchel, K.L., Kuijpers-Jagtman, A.M. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. (1997) [Pubmed]
  14. Changes of vertical skeletal morphology in patients with complete unilateral and bilateral cleft lip and palate. Lisson, J.A., Hanke, I., Tränkmann, J. Cleft Palate Craniofac. J. (2005) [Pubmed]
  15. Timing of exchange of the maxillary deciduous and permanent teeth in boys with three types of orofacial clefts. Peterka, M., Peterková, R., Likovský, Z. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. (1996) [Pubmed]
  16. New non-peptidic inhibitors of papain derived from etacrynic acid. Kaeppler, U., Schirmeister, T. Medicinal chemistry (Sh⁻ariqah, United Arab Emirates) (2005) [Pubmed]
  17. Nasal airflow and olfactory function after the repair of cleft palate (with and without cleft lip). Grossmann, N., Brin, I., Aizenbud, D., Sichel, J.Y., Gross-Isseroff, R., Steiner, J. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2005) [Pubmed]
  18. Long-term results on the quadrangular osteotomy. Brouns, J.J., Freihofer, H.P. International journal of oral and maxillofacial surgery. (1992) [Pubmed]
  19. Vertical changes in patients with complete unilateral and bilateral cleft lip, alveolus and palate. Lisson, J.A., Hanke, I., Tränkmann, J. Journal of orofacial orthopedics = Fortschritte der Kieferorthopädie : Organ/official journal Deutsche Gesellschaft für Kieferorthopädie. (2004) [Pubmed]
  20. The comparison of two-dimensional and three-dimensional methods in the evaluation of the secondary alveolar bone grafting. Jia, Y., Fu, M., Ma, L. Zhonghua Kou Qiang Yi Xue Za Zhi (2002) [Pubmed]
  21. Analysis of primary gingivoperiosteoplasty in alveolar cleft repair. Part I: Facial growth. Henkel, K.O., Gundlach, K.K. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. (1997) [Pubmed]
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