Disease relevance of TMEM54

• One of eight new monoclonal antibodies generated, 12G2, specifically reacted not only with beta-casein, but also with human cervical adenocarcinoma cell line CAC-1 [1].
• The microbial degradation of chlorinated and nonchlorinated methanes, ethanes, and ethanes by a mixed methane-oxidizing culture grown under chemostat and batch conditions is evaluated and compared with that by two pure methanotrophic strains: CAC1 (isolated from the mixed culture) and Methylosinus trichosporium OB3b [2].
• RT-PCR analysis reveals that cervical squamous cell carcinoma (C-33A, MS-751 and QG-U), and endometrial adenocarcinoma (AN3-CA, KLE and Ishikawa), but not cervical adenocarcinoma (CAC-1 and OMC-4), expresses both or either one of the two human eag-related genes (HERG2 and 3, or KCNH6 and 7) [3].
• The subjects were 260 (108 girls, 152 boys) 6-yr-old Finnish-speaking non-syndromic children with isolated cleft palate (CP, n = 79), cleft lip/alveolus (CL(A), n = 76), unilateral (UCLP, n = 78), and bilateral (BCLP, n = 27) cleft lip and palate [4].
• Sixty per cent of primary MLSs and 57% of secondary lymphomas were reactive for BCLP [5].

High impact information on TMEM54

• We examined the effect of EGF on motility, migration, and morphology of a human adenocarcinoma cell line CAC-1 [6].
• To assess the roles of cyclic AMP (cAMP) signaling in detail, we generated knockout mutants of CPK1 and the adenylate cyclase gene CAC1 [7].
• The BCLP gene and deduced amino acid sequences were novel and showed no similarity to known cancer-associated genes in the database [8].
• To clarify the function of BCLP, BCLP cDNA was transfected into L929 cells, resulting in a significant increase in cell area, a downregulation of cell growth rate and a decrease in cell attachment [8].
• A newly characterized human endometrial adenocarcinoma cell line (CAC-1) differentiates in response to retinoic acid treatment [9].

Biological context of TMEM54

• To identify the gene encoding the putative protein (BCLP) defined by monoclonal antibody (mAb) 12G2, a complementary DNA library was constructed [1].
• A slight lag in cell growth was observed when CAC-1 cells were treated with 1 microM 13-cis or all-trans retinoic acid during a 12-day growth curve [9].
• The B-cell leukemia/lymphoma gene (bcl-2) produces a unique protein product (BCLP) that is believed to protect lymphoid cells from apoptosis [5].
• Gonial angle shows sex differences for BCLP only [10].
• Injection of Bclp causes the same cytoxic effects and alterations of the cuticule as those observed during mycosis, and may contribute to the virulence of strain 618 [11].

Anatomical context of TMEM54

• CAC-1 cells exhibited a similar response because they also organized actin filaments and enlarged in response to retinoic acid treatment [9].
• Differences in growth velocities were compared with those of 25 children with UCLP and 15 children with BCLP with delayed closure of hard palate (12 to 14 months) [12].
• The aim of this study was to describe maxillary and mandibular dental-arch form and occlusion in bilateral cleft of the lip and palate (BCLP) from 3 to 17 years of age and to compare their characteristics with a normative sample [13].
• The posterior height of the maxilla is significantly shorter in patients both with UCLP and BCLP at T(0) and T(1) [14].
• In boys with BCLP, the highest retardation of eruption was found in the permanent maxillary lateral incisor and in the permanent maxillary first molar [15].

Associations of TMEM54 with chemical compounds

• For first structure-activity-relationship studies modifications at various positions of the etacrynic acid structure have been investigated concerning inhibition potency against the CAC1 protease papain: length of the side chain, substitution pattern of the aromatic ring as well as influence and necessity of acidic groups, esters or amides [16].

Analytical, diagnostic and therapeutic context of TMEM54

• No significant differences were found between right and left nostrils within the BCLP patients and between them and the control group [17].
• Four patients needed surgical correction of conditions that should be considered complications resulting from the osteotomy, including a case of partial ischaemic necrosis of the premaxilla in a BCLP patient [18].
• AIMS AND METHODS: Twelve UCLP and eleven BCLP patients who had been treated according to the Hanover treatment protocol were evaluated by means of cephalometric analysis and cast measurements [19].
• METHODS: Nine complete cleft lip and palate patients (8 UCLP, 1 BCLP) at least 6 months post secondary alveolar bone grafting were selected [20].
• The following material was studied: lateral head X-rays and plaster casts from 146 patients with unilateral (UCLP) and bilateral (BCLP) clefts of lip and palate from birth to 16 years of age [21].

References