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Gene Review

SYNC  -  syncoilin, intermediate filament protein

Homo sapiens

Synonyms: SYNC1, SYNCOILIN, Syncoilin, Syncoilin intermediate filament 1, Syncoilin-1
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Disease relevance of SYNC1


Psychiatry related information on SYNC1

  • By the end of the decade, the alcoholism system and drug addiction/use system were extremely out of sync [3].

High impact information on SYNC1

  • Two of the 63 patients carry truncation mutations in the C-terminal domain of alphaBC, four carry missense mutations in the head or tail region of desmin, and none carries a mutation in syncoilin or telethonin [4].
  • Kinetic analysis using cognate hairpin oligonucleotide and one and two-site plasmids as substrates allowed us to identify two types of communication signals propagated through the dimer-dimer interface in the Bse634I tetramer: the inhibitory, or "stopper" and the activating, or "sync" signal [5].
  • The time-resolved fluorescence behavior of tryptophan residues in isolated human hemoglobin subunits was determined using a sync-pumped dye laser system and time-correlated single photon counting detection [6].
  • The pattern of syncoilin immunolabeling in these diseases appeared to reflect a rearrangement of the intermediate filament-associated cytoskeleton that characterizes both muscle fiber development and conditions in which the cytoskeletal organization of the muscle fiber is significantly affected [1].
  • We have recently shown that syncoilin interacts with desmin in skeletal muscle and has a role in attaching and organising desmin filaments to the Z-lines [2].

Biological context of SYNC1


Anatomical context of SYNC1

  • Syncoilin may have a role in linking the desmin-associated intermediate filament network of the muscle fiber with the dystrophin-associated protein complex (DAPC) [1].
  • We have analysed patients with desmin accumulation and have found that syncoilin is both upregulated at the sarcolemma and aggregates with desmin indicating the presence of two distinct protein populations [2].

Analytical, diagnostic and therapeutic context of SYNC1

  • Chronobiologists out of sync over light therapy patents [8].
  • MATERIALS AND METHODS: A Complementary Spatial Modulation of Magnetization (C-SPAMM) tagged cine sequence triggered by an electrocardiogram (ECG) simulator was used to image a volunteer while speaking the syllable pairs /a/-/u/, /i/-/u/, and the words "golly" and "Tamil" in sync with the imaging sequence [9].
  • Ambulatory surgery centers (ASCs) must keep in sync with this change or fail to survive the current market forces [10].


  1. Syncoilin upregulation in muscle of patients with neuromuscular disease. Brown, S.C., Torelli, S., Ugo, I., De Biasia, F., Howman, E.V., Poon, E., Britton, J., Davies, K.E., Muntoni, F. Muscle Nerve (2005) [Pubmed]
  2. Syncoilin accumulation in two patients with desmin-related myopathy. Howman, E.V., Sullivan, N., Poon, E.P., Britton, J.E., Hilton-Jones, D., Davies, K.E. Neuromuscul. Disord. (2003) [Pubmed]
  3. Chemical dependency treatment: the integration of the alcoholism and drug addiction/use treatment systems. Rawson, R.A. The International journal of the addictions. (1990) [Pubmed]
  4. Myofibrillar myopathy: clinical, morphological and genetic studies in 63 patients. Selcen, D., Ohno, K., Engel, A.G. Brain (2004) [Pubmed]
  5. Allosteric Communication Network in the Tetrameric Restriction Endonuclease Bse634I. Zaremba, M., Sasnauskas, G., Urbanke, C., Siksnys, V. J. Mol. Biol. (2006) [Pubmed]
  6. A fluorescence decay time study of tryptophan in isolated hemoglobin subunits. Albani, J., Alpert, B., Krajcarski, D.T., Szabo, A.G. FEBS Lett. (1985) [Pubmed]
  7. The body in sync: understanding perfusion, fluid balance and all things cardiac. Mattera, C.J. JEMS : a journal of emergency medical services. (2005) [Pubmed]
  8. Chronobiologists out of sync over light therapy patents. Nowak, R. Science (1994) [Pubmed]
  9. Recording high quality speech during tagged cine-MRI studies using a fiber optic microphone. NessAiver, M.S., Stone, M., Parthasarathy, V., Kahana, Y., Paritsky, A., Paritsky, A. Journal of magnetic resonance imaging : JMRI. (2006) [Pubmed]
  10. Ambulatory purchasing: harnessing supply costs. Jager, P.A. Journal of healthcare resource management. (1997) [Pubmed]
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