Disease relevance of SYNC1

• Syncoilin upregulation in muscle of patients with neuromuscular disease [1].
• We have evaluated syncoilin in a range of neuromuscular disorders including Duchenne and Becker muscular dystrophy, central core disease, congenital muscular dystrophies, and neurogenic disorders [1].
• Syncoilin accumulation in two patients with desmin-related myopathy [2].

Psychiatry related information on SYNC1

• By the end of the decade, the alcoholism system and drug addiction/use system were extremely out of sync [3].

High impact information on SYNC1

• Two of the 63 patients carry truncation mutations in the C-terminal domain of alphaBC, four carry missense mutations in the head or tail region of desmin, and none carries a mutation in syncoilin or telethonin [4].
• Kinetic analysis using cognate hairpin oligonucleotide and one and two-site plasmids as substrates allowed us to identify two types of communication signals propagated through the dimer-dimer interface in the Bse634I tetramer: the inhibitory, or "stopper" and the activating, or "sync" signal [5].
• The time-resolved fluorescence behavior of tryptophan residues in isolated human hemoglobin subunits was determined using a sync-pumped dye laser system and time-correlated single photon counting detection [6].
• The pattern of syncoilin immunolabeling in these diseases appeared to reflect a rearrangement of the intermediate filament-associated cytoskeleton that characterizes both muscle fiber development and conditions in which the cytoskeletal organization of the muscle fiber is significantly affected [1].
• We have recently shown that syncoilin interacts with desmin in skeletal muscle and has a role in attaching and organising desmin filaments to the Z-lines [2].

Biological context of SYNC1

• The body in sync: understanding perfusion, fluid balance and all things cardiac [7].

Anatomical context of SYNC1

• Syncoilin may have a role in linking the desmin-associated intermediate filament network of the muscle fiber with the dystrophin-associated protein complex (DAPC) [1].
• We have analysed patients with desmin accumulation and have found that syncoilin is both upregulated at the sarcolemma and aggregates with desmin indicating the presence of two distinct protein populations [2].

Analytical, diagnostic and therapeutic context of SYNC1

• Chronobiologists out of sync over light therapy patents [8].
• MATERIALS AND METHODS: A Complementary Spatial Modulation of Magnetization (C-SPAMM) tagged cine sequence triggered by an electrocardiogram (ECG) simulator was used to image a volunteer while speaking the syllable pairs /a/-/u/, /i/-/u/, and the words "golly" and "Tamil" in sync with the imaging sequence [9].
• Ambulatory surgery centers (ASCs) must keep in sync with this change or fail to survive the current market forces [10].

References