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Gene Review

GPSC  -  gliosis, familial progressive subcortical

Homo sapiens

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Disease relevance of GPSC


Psychiatry related information on GPSC


High impact information on GPSC

  • Whole cell voltage-clamp recordings showed that the postsynaptic GABA(B) and depolarizing GABA components of the GPSC overlap substantially, allowing the GABA(B)-mediated hyperpolarization to suppress the excitation mediated by the depolarizing GABA component [4].
  • Further voltage-clamp recordings showed that CGP 55845A increased the duration of the depolarizing GABA component of the GPSC even when the GABA(B) component had already been blocked by internal QX-314, suggesting that CGP 55845A also increased the duration of GABA release [4].
  • To induce EAE, rats preimmunized with hsp-CNP peptide were challenged with guinea pig spinal cord (GPSC) emulsified in CFA [5].
  • These data indicate that the GABAD component of the GPSC is predominantly carried by HCO3-. While this result supports the recently propsed chloride accumulation model, the model in its present form cannot explain the inward current-outward current polarity sequence of the GPSC recorded with the high [Cl-]/low [HCO3-] intracellular solution [6].


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  3. Physical activity, global physical self-concept, and adolescent smoking. Rodriguez, D., Audrain-McGovern, J. Annals of behavioral medicine : a publication of the Society of Behavioral Medicine. (2005) [Pubmed]
  4. Synaptic depolarizing GABA Response in adults is excitatory and proconvulsive when GABAB receptors are blocked. Kantrowitz, J.T., Francis, N.N., Salah, A., Perkins, K.L. J. Neurophysiol. (2005) [Pubmed]
  5. Heat shock proteins and experimental autoimmune encephalomyelitis (EAE): I. Immunization with a peptide of the myelin protein 2',3' cyclic nucleotide 3' phosphodiesterase that is cross-reactive with a heat shock protein alters the course of EAE. Birnbaum, G., Kotilinek, L., Schlievert, P., Clark, H.B., Trotter, J., Horvath, E., Gao, E., Cox, M., Braun, P.E. J. Neurosci. Res. (1996) [Pubmed]
  6. Ionic basis of the postsynaptic depolarizing GABA response in hippocampal pyramidal cells. Perkins, K.L., Wong, R.K. J. Neurophysiol. (1996) [Pubmed]
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