Disease relevance of GPSC

• When these conditions were excluded, GPSC indicated the diagnosis of subacute sclerosing panencephalitis or other encephalitides [1].
• Generalized periodic suppression bursts and generalized periodic slow-wave complexes (GPSC) occurred in patients under anesthesia or drug intoxication, and with anoxic/metabolic encephalopathies [1].
• Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) was induced in rats with an emulsion of guinea-pig spinal cord tissue (GPSC) in complete Freund's adjuvant (CFA) enriched with Mycobacterium tuberculosis H37RA (Tbc) [2].

Psychiatry related information on GPSC

• Briefly, GPSC is a general perception of one's physical self, including appearance and physical activity competence [3].
• One such variable is global physical self-concept (GPSC) [3].

High impact information on GPSC

• Whole cell voltage-clamp recordings showed that the postsynaptic GABA(B) and depolarizing GABA components of the GPSC overlap substantially, allowing the GABA(B)-mediated hyperpolarization to suppress the excitation mediated by the depolarizing GABA component [4].
• Further voltage-clamp recordings showed that CGP 55845A increased the duration of the depolarizing GABA component of the GPSC even when the GABA(B) component had already been blocked by internal QX-314, suggesting that CGP 55845A also increased the duration of GABA release [4].
• To induce EAE, rats preimmunized with hsp-CNP peptide were challenged with guinea pig spinal cord (GPSC) emulsified in CFA [5].
• These data indicate that the GABAD component of the GPSC is predominantly carried by HCO3-. While this result supports the recently propsed chloride accumulation model, the model in its present form cannot explain the inward current-outward current polarity sequence of the GPSC recorded with the high [Cl-]/low [HCO3-] intracellular solution [6].

References