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MeSH Review

Subacute Sclerosing Panencephalitis

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Disease relevance of Subacute Sclerosing Panencephalitis


Psychiatry related information on Subacute Sclerosing Panencephalitis


High impact information on Subacute Sclerosing Panencephalitis


Chemical compound and disease context of Subacute Sclerosing Panencephalitis


Biological context of Subacute Sclerosing Panencephalitis

  • The data show that the loss of the ET-1 signaling pathway in C6/SSPE and C6/CDV cells is due to a receptor downregulation at the transcriptional level [17].
  • F(ab')2 fragments prepared from SSPE IgG retained their activity, which showed that the assay measures a true antigen-antibody reaction rather than nonspecific adherence to IgG to MBP [18].
  • CONCLUSION: To our knowledge, this study is the first to demonstrate the possibility that the IL-4 promoter gene -589 T gene polymorphism with increased IL-4 synthesis in combination with IRF-1 allele 1 confers host genetic susceptibility to SSPE in Japanese subjects [19].
  • For these four patients, CSF ribavirin concentrations were maintained at a level at which SSPE virus replication was almost completely inhibited in vitro and in vivo, whereas the concentration was lower in the patient without clinical improvement [20].
  • The frequency of the genotype combination of IL-4 promoter -589 T and IRF-1 allele 1 (at least 1 allele) in patients with SSPE was much higher than that in the controls (47.7% vs 22.0%; P =.003, chi2 analysis) [19].

Anatomical context of Subacute Sclerosing Panencephalitis

  • To further characterize the TCR V alpha and V beta repertoire in MS plaque tissue, we examined a series of 26 histologically well-characterized central nervous system (CNS) tissue specimens from six MS patients as well as samples from five normal postmortem cases and a case of subacute sclerosing panencephalitis [21].
  • Indirect immunofluorescent analysis revealed that sera from five patients with subacute sclerosing panencephalitis possessed IgD antibodies directed against measles virus components in persistently infected HeLa cells [22].
  • Single cell clones from the antisense-transfected C6/SSPE cells appear to be totally free of virus in cocultivation with Vero cells, suggesting that they are really cured [23].
  • There were no significant differences between the CSF results in patients with NID and MS but the OKT3 lymphocytes were reduced in CSF samples from patients with SSPE [24].
  • The results suggest that T-lymphocytes are involved in the pathogenesis of both MS and SSPE [25].

Gene context of Subacute Sclerosing Panencephalitis


Analytical, diagnostic and therapeutic context of Subacute Sclerosing Panencephalitis


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  10. Inosiplex for SSPE. Chalmers, T.C., Smith, H. Lancet (1982) [Pubmed]
  11. Levodopa in subacute sclerosing panencephalitis. Halikowski, B., Piotropawlowska-Weinert, M. Lancet (1977) [Pubmed]
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  17. Downregulation of endothelin receptor mRNA synthesis in C6 rat astrocytoma cells by persistent measles virus and canine distemper virus infections. Meissner, N.N., Koschel, K. J. Virol. (1995) [Pubmed]
  18. CSF antibody to myelin basic protein. Measurement in patients with multiple sclerosis and subacute sclerosing panencephalitis. Panitch, H.S., Hooper, C.J., Johnson, K.P. Arch. Neurol. (1980) [Pubmed]
  19. Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis. Inoue, T., Kira, R., Nakao, F., Ihara, K., Bassuny, W.M., Kusuhara, K., Nihei, K., Takeshita, K., Hara, T. Arch. Neurol. (2002) [Pubmed]
  20. Pharmacokinetics and effects of ribavirin following intraventricular administration for treatment of subacute sclerosing panencephalitis. Hosoya, M., Mori, S., Tomoda, A., Mori, K., Sawaishi, Y., Kimura, H., Shigeta, S., Suzuki, H. Antimicrob. Agents Chemother. (2004) [Pubmed]
  21. T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions. Wucherpfennig, K.W., Newcombe, J., Li, H., Keddy, C., Cuzner, M.L., Hafler, D.A. J. Exp. Med. (1992) [Pubmed]
  22. Measles virus-specific IgD antibodies in patients with subacute sclerosing panencephalitis. Luster, M.I., Armen, R.C., Hallum, J.V., Leslie, G.A. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  23. Measles virus antisense sequences specifically cure cells persistently infected with measles virus. Koschel, K., Brinckmann, U., Hoyningen-Huene, V.V. Virology (1995) [Pubmed]
  24. Surface markers on lymphocytes from human cerebrospinal fluid. Identification by monoclonal antibodies. Marrosu, M.G., Ennas, M.G., Murru, M.R., Marrosu, G., Cianchetti, C., Manconi, P.E. J. Neuroimmunol. (1983) [Pubmed]
  25. Immunohistochemical identification of T-lymphocytes in the central nervous system of patients with multiple sclerosis and subacute sclerosing panencephalitis. Kreth, H.W., Dunker, R., Rodt, H., Meyermann, R. J. Neuroimmunol. (1982) [Pubmed]
  26. Analysis of measles virus binding sites of the CD46 gene in patients with subacute sclerosing panencephalitis. Kusuhara, K., Sasaki, Y., Nakao, F., Ihara, K., Hattori, H., Yamashita, S., Nihei, K., Koide, N., Aiba, H., Takeshita, K., Hara, T. J. Infect. Dis. (2000) [Pubmed]
  27. HLA and C4 in subacute sclerosing panencephalitis. Harada, F., Onisawa, S., Suzuki, K., Matsumoto, H., Sasazuki, T. Tissue Antigens (1987) [Pubmed]
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  30. Loss of the endothelin signal pathway in C6 rat glioma cells persistently infected with measles virus. Tas, P.W., Koschel, K. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  31. Immune response in subacute sclerosing panencephalitis: reduced antibody response to the matrix protein of measles virus. Wechsler, S.L., Weiner, H.L., Fields, B.N. J. Immunol. (1979) [Pubmed]
  32. Major histocompatibility complex class I expression on neurons in subacute sclerosing panencephalitis and experimental subacute measles encephalitis. Gogate, N., Swoveland, P., Yamabe, T., Verma, L., Woyciechowska, J., Tarnowska-Dziduszko, E., Dymecki, J., Dhib-Jalbut, S. J. Neuropathol. Exp. Neurol. (1996) [Pubmed]
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