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Gene Review

GPX2  -  glutathione peroxidase GPx

Arabidopsis thaliana

Synonyms: ATGPX2, GLUTATHIONE PEROXIDASE, T9H9.9, T9H9_9, glutathione peroxidase 2
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Disease relevance of ATGPX2

  • Four mature GPX isoenzymes with different subcellular distributions, AtGPX1, -2, -5 and -6, were overexpressed in Escherichia coli and characterized [1].

High impact information on ATGPX2

  • An Arabidopsis glutathione peroxidase functions as both a redox transducer and a scavenger in abscisic Acid and drought stress responses [2].
  • All GSTs except AtGSTF10 formed soluble proteins which catalysed a specific range of glutathione conjugation or glutathione peroxidase activities [3].
  • Thus, the cloned A. thaliana enzyme functions as glutathione peroxidase and, in the plant cell, may be involved in the removal of reactive organic hydroperoxides, such as the products of lipid peroxidation [4].
  • AtGSTF9 showed activity towards benzyl isothiocyanate (BITC) and an activity as glutathione peroxidase with cumene hydroperoxide (CumHPO) [5].
  • These finding suggest that GPX isoenzymes may function to detoxify H2O2 and organic hydroperoxides using thioredoxin in vivo and may also be involved in regulation of the cellular redox homeostasis by maintaining the thiol/disulfide or NADPH/NADP balance [1].

Associations of ATGPX2 with chemical compounds


  1. Hydroperoxide reduction by thioredoxin-specific glutathione peroxidase isoenzymes of Arabidopsis thaliana. Iqbal, A., Yabuta, Y., Takeda, T., Nakano, Y., Shigeoka, S. FEBS J. (2006) [Pubmed]
  2. An Arabidopsis glutathione peroxidase functions as both a redox transducer and a scavenger in abscisic Acid and drought stress responses. Miao, Y., Lv, D., Wang, P., Wang, X.C., Chen, J., Miao, C., Song, C.P. Plant Cell (2006) [Pubmed]
  3. Probing the diversity of the Arabidopsis glutathione S-transferase gene family. Wagner, U., Edwards, R., Dixon, D.P., Mauch, F. Plant Mol. Biol. (2002) [Pubmed]
  4. A glutathione S-transferase with glutathione-peroxidase activity from Arabidopsis thaliana. Molecular cloning and functional characterization. Bartling, D., Radzio, R., Steiner, U., Weiler, E.W. Eur. J. Biochem. (1993) [Pubmed]
  5. Characterization of two Arabidopsis thaliana glutathione S-transferases. Nutricati, E., Miceli, A., Blando, F., De Bellis, L. Plant Cell Rep. (2006) [Pubmed]
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