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Gene Review

PKT3  -  3-ketoacyl-CoA thiolase 2

Arabidopsis thaliana

Synonyms: 3-KETOACYL-COA THIOLASE 2, KAT2, PED1, PEROXISOME DEFECTIVE 1, peroxisomal 3-ketoacyl-CoA thiolase 3, ...
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High impact information on PED1

  • Etiolated cotyledons of both ped1 and ped2 mutants have glyoxysomes with abnormal morphology [1].
  • Here we describe the isolation and characterization of an Arabidopsis peroxin mutant, pex7-1, which displays peroxisome-defective phenotypes including reduced PTS2 protein import [2].
  • Mechanical damage triggered the local and systemic induction of only ACX1 among acyl-coenzyme A oxidase (ACX) genes, and KAT2/PED1 among 3-ketoacyl-coenzyme A thiolase (KAT) genes in Arabidopsis [3].
  • Furthermore, a role for KAT2 in the auxin-controlled vascular patterning of leaves is discussed [4].
  • The transcript levels of 12-oxo-PDA reductase 1 and 12-oxo-PDA reductase 3 also increase in senescing leaves, as does PED1 (encoding a 3-keto-acyl-thiolase for beta-oxidation) [5].

Biological context of PED1


Anatomical context of PED1

  • The peroxisomes in cotyledons of kat2 seedlings are very large, the total peroxisomal compartment is dramatically increased, and some peroxisomes contain unusual membrane inclusions [6].

Associations of PED1 with chemical compounds

  • Reduced expression of ACX1 or KAT2 genes, in transgenic plants expressing their corresponding mRNAs in antisense orientation, correlated with defective wound-activated synthesis of JA and with reduced expression of JA-responsive genes [3].
  • In the homozygous kat2 mutant, seedling growth is dependent upon exogenous sugar, and storage triacylglycerol (TAG) and lipid bodies persist in green cotyledons [6].
  • Analysis of gene co-expression clusters in Arabidopsis suggests a role for peroxisomal KAT2 in beta-oxidation, while KAT5 co-expresses with genes of the flavonoid biosynthesis pathway and cytosolic ACAT2 clearly co-expresses with genes of the cytosolic mevalonate biosynthesis pathway [7].
  • This sucrose is derived from triacylglycerol as demonstrated by two mutants disrupted in the conversion of triacylglycerol into sucrose, kat2 and icl1, which do not accumulate sucrose in the presence of ABA [8].

Other interactions of PED1

  • PEX1 and 3-ketoacyl thiolase (PED1) were expressed in roots, mature leaves, stems and flowers [9].


  1. 2,4-Dichlorophenoxybutyric acid-resistant mutants of Arabidopsis have defects in glyoxysomal fatty acid beta-oxidation. Hayashi, M., Toriyama, K., Kondo, M., Nishimura, M. Plant Cell (1998) [Pubmed]
  2. The Arabidopsis peroxisomal targeting signal type 2 receptor PEX7 is necessary for peroxisome function and dependent on PEX5. Woodward, A.W., Bartel, B. Mol. Biol. Cell (2005) [Pubmed]
  3. Gene-specific involvement of beta-oxidation in wound-activated responses in Arabidopsis. Cruz Castillo, M., Martínez, C., Buchala, A., Métraux, J.P., León, J. Plant Physiol. (2004) [Pubmed]
  4. Auxin activates KAT1 and KAT2, two K+-channel genes expressed in seedlings of Arabidopsis thaliana. Philippar, K., Ivashikina, N., Ache, P., Christian, M., Lüthen, H., Palme, K., Hedrich, R. Plant J. (2004) [Pubmed]
  5. Evidence supporting a role of jasmonic acid in Arabidopsis leaf senescence. He, Y., Fukushige, H., Hildebrand, D.F., Gan, S. Plant Physiol. (2002) [Pubmed]
  6. Requirement for 3-ketoacyl-CoA thiolase-2 in peroxisome development, fatty acid beta-oxidation and breakdown of triacylglycerol in lipid bodies of Arabidopsis seedlings. Germain, V., Rylott, E.L., Larson, T.R., Sherson, S.M., Bechtold, N., Carde, J.P., Bryce, J.H., Graham, I.A., Smith, S.M. Plant J. (2001) [Pubmed]
  7. Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes in Arabidopsis thaliana are targeted either to peroxisomes or cytosol but not to mitochondria. Carrie, C., Murcha, M.W., Millar, A.H., Smith, S.M., Whelan, J. Plant Mol. Biol. (2007) [Pubmed]
  8. Germination and storage reserve mobilization are regulated independently in Arabidopsis. Pritchard, S.L., Charlton, W.L., Baker, A., Graham, I.A. Plant J. (2002) [Pubmed]
  9. Non-coordinate expression of peroxisome biogenesis, beta-oxidation and glyoxylate cycle genes in mature Arabidopsis plants. Charlton, W.L., Johnson, B., Graham, I.A., Baker, A. Plant Cell Rep. (2005) [Pubmed]
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