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Gene Review

PEX1  -  peroxisome biogenesis protein 1

Arabidopsis thaliana

Synonyms: EMB2817, EMBRYO DEFECTIVE 2817, F8L15.15, peroxisome 1
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Disease relevance of PEX1

  • The poly[(R)-3-hydroxyalkanoate] (PHA) synthase gene (phaC(Ac)) of Aeromonas caviae FA440 was modified by adding a peroxisome targeting signal encoding the last 10 amino acids at the carboxyl-terminal of spinach glycolate oxidase [1].

High impact information on PEX1


Biological context of PEX1


Anatomical context of PEX1

  • We conclude that KATs and ACATs are present in the cytosol and peroxisome, but are not found in mitochondria [11].
  • Although AtSOX lacks a typical peroxisome-targeting signal, in vitro assays established that it is imported into peroxisomes [12].
  • They were found peripherally associated with peroxisome and ER membranes but not as covalently bound subunits of AtPex16p [13].
  • The R. communis enzyme would therefore appear to possess an additional glyoxysome/peroxisome targeting signal that is lacking in the B. napus protein [14].
  • In transient onion epidermis assay and in transgenic Arabidopsis plants, an interference with the actin cytoskeleton resulted in progressive loss of saltatory movement followed by the aggregation and a complete cessation of peroxisome motility within 30 min of drug application [15].

Associations of PEX1 with chemical compounds

  • Results suggest that lipids can be used as a source of carbon for respiration in germinating oilseeds and that products of fatty acid catabolism can pass from the peroxisome to the mitochondrion independently of the glyoxylate cycle [16].
  • The C18 JA precursor 12-oxo-phytodienoic acid (OPDA) is converted in the peroxisome to 3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0), which subsequently undergoes three rounds of beta-oxidation to yield JA [17].
  • A C-terminal dilysine motif, present in AtPex11c, -d and -e, was not necessary for AtPex11d-induced peroxisome elongation [18].
  • Analysis of mfp2-1 seedlings revealed that seed storage lipid was catabolized more slowly, long-chain acyl-CoA substrates accumulated and there was an increase in peroxisome size [19].
  • Requirement for 3-ketoacyl-CoA thiolase-2 in peroxisome development, fatty acid beta-oxidation and breakdown of triacylglycerol in lipid bodies of Arabidopsis seedlings [20].

Other interactions of PEX1


  1. Synthesis of a novel class of polyhydroxyalkanoates in Arabidopsis peroxisomes, and their use in monitoring short-chain-length intermediates of beta-oxidation. Arai, Y., Nakashita, H., Suzuki, Y., Kobayashi, Y., Shimizu, T., Yasuda, M., Doi, Y., Yamaguchi, I. Plant Cell Physiol. (2002) [Pubmed]
  2. AtPex14p maintains peroxisomal functions by determining protein targeting to three kinds of plant peroxisomes. Hayashi, M., Nito, K., Toriyama-Kato, K., Kondo, M., Yamaya, T., Nishimura, M. EMBO J. (2000) [Pubmed]
  3. Stress induces peroxisome biogenesis genes. Lopez-Huertas, E., Charlton, W.L., Johnson, B., Graham, I.A., Baker, A. EMBO J. (2000) [Pubmed]
  4. Arabidopsis peroxisomal citrate synthase is required for fatty acid respiration and seed germination. Pracharoenwattana, I., Cornah, J.E., Smith, S.M. Plant Cell (2005) [Pubmed]
  5. Identification and functional characterization of Arabidopsis PEROXIN4 and the interacting protein PEROXIN22. Zolman, B.K., Monroe-Augustus, M., Silva, I.D., Bartel, B. Plant Cell (2005) [Pubmed]
  6. Requirement of the C3HC4 zinc RING finger of the Arabidopsis PEX10 for photorespiration and leaf peroxisome contact with chloroplasts. Schumann, U., Prestele, J., O'Geen, H., Brueggeman, R., Wanner, G., Gietl, C. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  7. AthPEX10, a nuclear gene essential for peroxisome and storage organelle formation during Arabidopsis embryogenesis. Schumann, U., Wanner, G., Veenhuis, M., Schmid, M., Gietl, C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. The Arabidopsis PEX12 gene is required for peroxisome biogenesis and is essential for development. Fan, J., Quan, S., Orth, T., Awai, C., Chory, J., Hu, J. Plant Physiol. (2005) [Pubmed]
  9. Subcellular targeting of nine calcium-dependent protein kinase isoforms from Arabidopsis. Dammann, C., Ichida, A., Hong, B., Romanowsky, S.M., Hrabak, E.M., Harmon, A.C., Pickard, B.G., Harper, J.F. Plant Physiol. (2003) [Pubmed]
  10. AraPerox. A database of putative Arabidopsis proteins from plant peroxisomes. Reumann, S., Ma, C., Lemke, S., Babujee, L. Plant Physiol. (2004) [Pubmed]
  11. Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes in Arabidopsis thaliana are targeted either to peroxisomes or cytosol but not to mitochondria. Carrie, C., Murcha, M.W., Millar, A.H., Smith, S.M., Whelan, J. Plant Mol. Biol. (2007) [Pubmed]
  12. Characterization and metabolic function of a peroxisomal sarcosine and pipecolate oxidase from Arabidopsis. Goyer, A., Johnson, T.L., Olsen, L.J., Collakova, E., Shachar-Hill, Y., Rhodes, D., Hanson, A.D. J. Biol. Chem. (2004) [Pubmed]
  13. Arabidopsis peroxin 16 coexists at steady state in peroxisomes and endoplasmic reticulum. Karnik, S.K., Trelease, R.N. Plant Physiol. (2005) [Pubmed]
  14. Castor bean isocitrate lyase lacking the putative peroxisomal targeting signal 1 ARM is imported into plant peroxisomes both in vitro and in vivo. Gao, X., Marrison, J.L., Pool, M.R., Leech, R.M., Baker, A. Plant Physiol. (1996) [Pubmed]
  15. Simultaneous visualization of peroxisomes and cytoskeletal elements reveals actin and not microtubule-based peroxisome motility in plants. Mathur, J., Mathur, N., Hülskamp, M. Plant Physiol. (2002) [Pubmed]
  16. Postgerminative growth and lipid catabolism in oilseeds lacking the glyoxylate cycle. Eastmond, P.J., Germain, V., Lange, P.R., Bryce, J.H., Smith, S.M., Graham, I.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  17. Identification of a Peroxisomal Acyl-activating Enzyme Involved in the Biosynthesis of Jasmonic Acid in Arabidopsis. Koo, A.J., Chung, H.S., Kobayashi, Y., Howe, G.A. J. Biol. Chem. (2006) [Pubmed]
  18. Five Arabidopsis peroxin 11 homologs individually promote peroxisome elongation, duplication or aggregation. Lingard, M.J., Trelease, R.N. J. Cell. Sci. (2006) [Pubmed]
  19. The Arabidopsis thaliana multifunctional protein gene (MFP2) of peroxisomal beta-oxidation is essential for seedling establishment. Rylott, E.L., Eastmond, P.J., Gilday, A.D., Slocombe, S.P., Larson, T.R., Baker, A., Graham, I.A. Plant J. (2006) [Pubmed]
  20. Requirement for 3-ketoacyl-CoA thiolase-2 in peroxisome development, fatty acid beta-oxidation and breakdown of triacylglycerol in lipid bodies of Arabidopsis seedlings. Germain, V., Rylott, E.L., Larson, T.R., Sherson, S.M., Bechtold, N., Carde, J.P., Bryce, J.H., Graham, I.A., Smith, S.M. Plant J. (2001) [Pubmed]
  21. The Arabidopsis peroxisomal targeting signal type 2 receptor PEX7 is necessary for peroxisome function and dependent on PEX5. Woodward, A.W., Bartel, B. Mol. Biol. Cell (2005) [Pubmed]
  22. An Arabidopsis pex10 null mutant is embryo lethal, implicating peroxisomes in an essential role during plant embryogenesis. Sparkes, I.A., Brandizzi, F., Slocombe, S.P., El-Shami, M., Hawes, C., Baker, A. Plant Physiol. (2003) [Pubmed]
  23. The peroxisome deficient Arabidopsis mutant sse1 exhibits impaired fatty acid synthesis. Lin, Y., Cluette-Brown, J.E., Goodman, H.M. Plant Physiol. (2004) [Pubmed]
  24. Arabidopsis 22-kilodalton peroxisomal membrane protein. Nucleotide sequence analysis and biochemical characterization. Tugal, H.B., Pool, M., Baker, A. Plant Physiol. (1999) [Pubmed]
  25. Peroxisomal localization of a myosin XI isoform in Arabidopsis thaliana. Hashimoto, K., Igarashi, H., Mano, S., Nishimura, M., Shimmen, T., Yokota, E. Plant Cell Physiol. (2005) [Pubmed]
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