High impact information on AGC2-1

• Plant hormones, auxin and cytokinin, synergistically activate the AtPDK1-regulated AGC2-1 kinase, indicative of a role in growth and cell division [1].
• Here we report on a lipid-signalling pathway in plants that is downstream of phosphatidic acid and involves the Arabidopsis protein kinase, AGC2-1, regulated by the 3'-phosphoinositide-dependent kinase-1 (AtPDK1) [1].
• The agc2-1 knockout mutation results in a reduction of root hair length, suggesting a role for AGC2-1 in root hair growth and development [1].
• Abscisic acid and H(2)O(2) induction of AtLEA5 was also independent of the OXI1 protein kinase [2].
• Here we show that expression of an Arabidopsis thaliana gene (OXI1) encoding a serine/threonine kinase is induced in response to a wide range of H2O2-generating stimuli [3].

Biological context of AGC2-1

• AtPDK1 is ubiquitously expressed in all plant tissues, whereas expression of AGC2-1 is abundant in fast-growing organs and dividing cells, and activated during re-entry of cells into the cell cycle after sugar starvation-induced G1-phase arrest [1].
• Thus, OXI1 is an essential part of the signal transduction pathway linking oxidative burst signals to diverse downstream responses [3].

Other interactions of AGC2-1

• We have used RNA interference to knock out the expression of PDK1 and OXI1 and to study the effects on PTI1-2 activity [4].

References