Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

LOX2 - lipoxygenase 2

Arabidopsis thaliana

Synonyms: ARABIODOPSIS THALIANA LIPOXYGENASE 2, ATLOX2

Spoel, S.H. et al., Bell, E. et al., Jensen, A.B. et al., Freire, M.A. et al., Moran, P.J. et al., et al.

Freire, Tourneur, Granier, Camonis, El Amrani, Browning, Robaglia,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LOX2

Arabidopsis plants unable to accumulate SA produced 25-fold higher levels of JA and showed enhanced expression of the JA-responsive genes LOX2, PDF1.2, and VSP in response to infection by Pseudomonas syringae pv tomato DC3000, indicating that in wild-type plants, pathogen-induced SA accumulation is associated with the suppression of JA signaling [1].
To identify jasmonate-signalling mutants, we used a fusion genetic strategy in which the firefly luciferase (FLUC) and Escherichia coli beta-glucuronidase (GUS) reporters were expressed under control of the jasmonate-responsive LOX2 promoter [2].

High impact information on LOX2

The potential involvement of a specific Arabidopsis thaliana lipoxygenase isozyme, LOX2, in the biosynthesis of the plant growth regulators jasmonic acid (JA) and abscisic acid was investigated [3].
The reduction in LOX2 levels caused no obvious changes in plant growth or in the accumulation of abscisic acid [3].
Northern-blot analysis showed that IAA induced the jasmonate-responsive lipoxygenase 2, AOS, and AtVSP gene transcripts and induction was strongly impaired in axr1-3 [4].
AtLox2 encodes a 102-kD protein, AtLOX2, which has 42 to 45% amino acid sequence identity with other plant LOX sequences [5].
Deletion analysis maps the region of AtLOX2 involved in interaction with AteIF(iso)4E between amino acids 175 and 232 [6].

Biological context of LOX2

Arabidopsis lipoxygenase 1 (cytoplasmic) expression is greatly increased but lipoxygenase 2 (plastidial) expression is sharply reduced during leaf senescence [7].

Associations of LOX2 with chemical compounds

PDF1.2 and LOX2 induction by aphids did not occur in infested leaves of the JA-resistant coi1-1 mutant [8].
Transcripts encoding JA-inducible lipoxygenase (LOX2) and SA/JA-inducible Phe-ammonia lyase increased 1.5- to 2-fold [8].

Analytical, diagnostic and therapeutic context of LOX2

A two-hybrid assay revealed that AtLOX2 is also able to interact with both wheat initiation factors 4E and 4E(iso) [6].

References

NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol. Spoel, S.H., Koornneef, A., Claessens, S.M., Korzelius, J.P., Van Pelt, J.A., Mueller, M.J., Buchala, A.J., Métraux, J.P., Brown, R., Kazan, K., Van Loon, L.C., Dong, X., Pieterse, C.M. Plant Cell (2003) [Pubmed]
Fusion genetic analysis of jasmonate-signalling mutants in Arabidopsis. Jensen, A.B., Raventos, D., Mundy, J. Plant J. (2002) [Pubmed]
A chloroplast lipoxygenase is required for wound-induced jasmonic acid accumulation in Arabidopsis. Bell, E., Creelman, R.A., Mullet, J.E. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
An Arabidopsis mutant defective in jasmonate response is allelic to the auxin-signaling mutant axr1. Tiryaki, I., Staswick, P.E. Plant Physiol. (2002) [Pubmed]
Characterization of an Arabidopsis lipoxygenase gene responsive to methyl jasmonate and wounding. Bell, E., Mullet, J.E. Plant Physiol. (1993) [Pubmed]
Plant lipoxygenase 2 is a translation initiation factor-4E-binding protein. Freire, M.A., Tourneur, C., Granier, F., Camonis, J., El Amrani, A., Browning, K.S., Robaglia, C. Plant Mol. Biol. (2000) [Pubmed]
Evidence supporting a role of jasmonic acid in Arabidopsis leaf senescence. He, Y., Fukushige, H., Hildebrand, D.F., Gan, S. Plant Physiol. (2002) [Pubmed]
Molecular responses to aphid feeding in Arabidopsis in relation to plant defense pathways. Moran, P.J., Thompson, G.A. Plant Physiol. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

alox5b.3	Danio rerio
alox5b.2	Danio rerio
Os02g0194700	Oryza sativa Japonica Group
Os08g0508800	Oryza sativa Japonica Group
Os08g0509100	Oryza sativa Japonica Group

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.