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Gene Review

LOX2  -  lipoxygenase 2

Arabidopsis thaliana

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Disease relevance of LOX2

  • Arabidopsis plants unable to accumulate SA produced 25-fold higher levels of JA and showed enhanced expression of the JA-responsive genes LOX2, PDF1.2, and VSP in response to infection by Pseudomonas syringae pv tomato DC3000, indicating that in wild-type plants, pathogen-induced SA accumulation is associated with the suppression of JA signaling [1].
  • To identify jasmonate-signalling mutants, we used a fusion genetic strategy in which the firefly luciferase (FLUC) and Escherichia coli beta-glucuronidase (GUS) reporters were expressed under control of the jasmonate-responsive LOX2 promoter [2].

High impact information on LOX2


Biological context of LOX2


Associations of LOX2 with chemical compounds

  • PDF1.2 and LOX2 induction by aphids did not occur in infested leaves of the JA-resistant coi1-1 mutant [8].
  • Transcripts encoding JA-inducible lipoxygenase (LOX2) and SA/JA-inducible Phe-ammonia lyase increased 1.5- to 2-fold [8].

Analytical, diagnostic and therapeutic context of LOX2


  1. NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol. Spoel, S.H., Koornneef, A., Claessens, S.M., Korzelius, J.P., Van Pelt, J.A., Mueller, M.J., Buchala, A.J., Métraux, J.P., Brown, R., Kazan, K., Van Loon, L.C., Dong, X., Pieterse, C.M. Plant Cell (2003) [Pubmed]
  2. Fusion genetic analysis of jasmonate-signalling mutants in Arabidopsis. Jensen, A.B., Raventos, D., Mundy, J. Plant J. (2002) [Pubmed]
  3. A chloroplast lipoxygenase is required for wound-induced jasmonic acid accumulation in Arabidopsis. Bell, E., Creelman, R.A., Mullet, J.E. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. An Arabidopsis mutant defective in jasmonate response is allelic to the auxin-signaling mutant axr1. Tiryaki, I., Staswick, P.E. Plant Physiol. (2002) [Pubmed]
  5. Characterization of an Arabidopsis lipoxygenase gene responsive to methyl jasmonate and wounding. Bell, E., Mullet, J.E. Plant Physiol. (1993) [Pubmed]
  6. Plant lipoxygenase 2 is a translation initiation factor-4E-binding protein. Freire, M.A., Tourneur, C., Granier, F., Camonis, J., El Amrani, A., Browning, K.S., Robaglia, C. Plant Mol. Biol. (2000) [Pubmed]
  7. Evidence supporting a role of jasmonic acid in Arabidopsis leaf senescence. He, Y., Fukushige, H., Hildebrand, D.F., Gan, S. Plant Physiol. (2002) [Pubmed]
  8. Molecular responses to aphid feeding in Arabidopsis in relation to plant defense pathways. Moran, P.J., Thompson, G.A. Plant Physiol. (2001) [Pubmed]
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