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Gene Review

LOX1  -  lipoxygenase 1

Arabidopsis thaliana

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Disease relevance of LOX1

  • Expression of the LOX1 gene was examined following infiltration of leaves with virulent (Psm ES4326) and avirulent (Pst MM1065) strains of Pseudomonas syringae [1].

Psychiatry related information on LOX1


High impact information on LOX1


Biological context of LOX1


Associations of LOX1 with chemical compounds

  • In mature plants, LOX1 mRNA levels increased upon treatment with the stress-related hormones abscisic acid and methyl jasmonate and remained high for at least 96 h [1].
  • Trans-2-hexenal induction thus closely mimics the group of genes induced by methyl jasmonate (MeJA), also a LOX-derived volatile [11].
  • The differences in C6-aldehyde formation among the fatty acid mutants of Arabidopsis appeared not to result from alteration of lipoxygenase/hydroperoxide lyase pathway enzymes [12].
  • Our results also suggest that AOS expression is limiting JA levels in wounded plants, but that the AOS hydroperoxide substrate levels, controlled by upstream enzymes (lipoxygenase and phospholipase), determine JA levels in unwounded plants [13].
  • The inductive effect seemed to be limited to C6-related volatiles, as C8-, C9- and other related volatiles did not induce LOX mRNA levels [11].

Physical interactions of LOX1

  • A search for plant eIF4E-binding proteins from Arcabictopsis thaliana using the yeast genetic interaction system identified a clone encoding a lipoxygenase type 2 (AtLOX2) [14].

Other interactions of LOX1


Analytical, diagnostic and therapeutic context of LOX1


  1. An Arabidopsis thaliana lipoxygenase gene can be induced by pathogens, abscisic acid, and methyl jasmonate. Melan, M.A., Dong, X., Endara, M.E., Davis, K.R., Ausubel, F.M., Peterman, T.K. Plant Physiol. (1993) [Pubmed]
  2. Role of the lipoxygenase/lyase pathway of host-food plants in the host searching behavior of two parasitoid species, Cotesia glomerata and Cotesia plutellae. Shiojiri, K., Ozawa, R., Matsui, K., Kishimoto, K., Kugimiya, S., Takabayashi, J. J. Chem. Ecol. (2006) [Pubmed]
  3. Conversion of cucumber linoleate 13-lipoxygenase to a 9-lipoxygenating species by site-directed mutagenesis. Hornung, E., Walther, M., Kühn, H., Feussner, I. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. A chloroplast lipoxygenase is required for wound-induced jasmonic acid accumulation in Arabidopsis. Bell, E., Creelman, R.A., Mullet, J.E. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  5. A novel class of oxylipins, sn1-O-(12-oxophytodienoyl)-sn2-O-(hexadecatrienoyl)-monogalactosyl Diglyceride, from Arabidopsis thaliana. Stelmach, B.A., Müller, A., Hennig, P., Gebhardt, S., Schubert-Zsilavecz, M., Weiler, E.W. J. Biol. Chem. (2001) [Pubmed]
  6. The upstream oxylipin profile of Arabidopsis thaliana: a tool to scan for oxidative stresses. Montillet, J.L., Cacas, J.L., Garnier, L., Montané, M.H., Douki, T., Bessoule, J.J., Polkowska-Kowalczyk, L., Maciejewska, U., Agnel, J.P., Vial, A., Triantaphylidès, C. Plant J. (2004) [Pubmed]
  7. Structure and sequence of the Arabidopsis thaliana lipoxygenase 1 gene. Melan, M.A., Nemhauser, J.L., Peterman, T.K. Biochim. Biophys. Acta (1994) [Pubmed]
  8. Characterization of an Arabidopsis lipoxygenase gene responsive to methyl jasmonate and wounding. Bell, E., Mullet, J.E. Plant Physiol. (1993) [Pubmed]
  9. Evidence supporting a role of jasmonic acid in Arabidopsis leaf senescence. He, Y., Fukushige, H., Hildebrand, D.F., Gan, S. Plant Physiol. (2002) [Pubmed]
  10. Molecular cloning and biochemical characterization of a lipoxygenase in almond (Prunus dulcis) seed. Mita, G., Gallo, A., Greco, V., Zasiura, C., Casey, R., Zacheo, G., Santino, A. Eur. J. Biochem. (2001) [Pubmed]
  11. C6-volatiles derived from the lipoxygenase pathway induce a subset of defense-related genes. Bate, N.J., Rothstein, S.J. Plant J. (1998) [Pubmed]
  12. The impact of alteration of polyunsaturated fatty acid levels on C6-aldehyde formation of Arabidopsis thaliana leaves. Zhuang, H., Hamilton-Kemp, T.R., Andersen, R.A., Hildebrand, D.F. Plant Physiol. (1996) [Pubmed]
  13. A knock-out mutation in allene oxide synthase results in male sterility and defective wound signal transduction in Arabidopsis due to a block in jasmonic acid biosynthesis. Park, J.H., Halitschke, R., Kim, H.B., Baldwin, I.T., Feldmann, K.A., Feyereisen, R. Plant J. (2002) [Pubmed]
  14. Plant lipoxygenase 2 is a translation initiation factor-4E-binding protein. Freire, M.A., Tourneur, C., Granier, F., Camonis, J., El Amrani, A., Browning, K.S., Robaglia, C. Plant Mol. Biol. (2000) [Pubmed]
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