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Gene Review:

RAB8A - small GTP-binding protein ARA3

Arabidopsis thaliana

Synonyms: ARA-3, ARA3, ATRAB8A, ATRABE1C, RAB GTPase homolog 8A, ...

Regad, F. et al., Pay, A. et al., Aspuria, E.T. et al., Moshkov, I.E. et al., Nahm, M.Y. et al., et al.

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Disease relevance of ARA3

Chimeric genes consisting of the cauliflower mosaic virus 35S promoter, a cDNA encoding a small GTP-binding protein from Arabidopsis thaliana (ara-2 or ara-4) and the terminator of the nopaline synthase gene were cloned into a binary vector [1].

High impact information on ARA3

Rab8 and Ara3 expression was increased within 10 min of ethylene treatment, although levels fell back significantly by 40 min [2].
The Arabidopsis genome contains 93 genes that encode small GTP-binding protein homologs [3].
In animals and yeast, the small GTP-binding protein Ran has multiple functions - it is involved in mediating (i) the directional passage of proteins and RNA through the nuclear pores in interphase cells; and (ii) the formation of spindle asters, the polymerization of microtubules, and the re-assembly of the nuclear envelope in mitotic cells [4].
A cDNA clone encoding a small GTP-binding protein, the ADP-ribosylation factor (ARF) was isolated from a cDNA library of Arabidopsis thaliana cultured cells [5].
Rab7 is a small GTP-binding protein important in early to late endosome/lysosome vesicular transport in mammalian cells [6].

References

Phenotypic instability of transgenic tobacco plants and their progenies expressing Arabidopsis thaliana small GTP-binding protein genes. Aspuria, E.T., Anai, T., Fujii, N., Ueda, T., Miyoshi, M., Matsui, M., Uchimiya, H. Mol. Gen. Genet. (1995) [Pubmed]
Ethylene regulates monomeric GTP-binding protein gene expression and activity in Arabidopsis. Moshkov, I.E., Mur, L.A., Novikova, G.V., Smith, A.R., Hall, M.A. Plant Physiol. (2003) [Pubmed]
Analysis of the small GTPase gene superfamily of Arabidopsis. Vernoud, V., Horton, A.C., Yang, Z., Nielsen, E. Plant Physiol. (2003) [Pubmed]
Plant RanGAPs are localized at the nuclear envelope in interphase and associated with microtubules in mitotic cells. Pay, A., Resch, K., Frohnmeyer, H., Fejes, E., Nagy, F., Nick, P. Plant J. (2002) [Pubmed]
cDNA cloning and expression of an Arabidopsis GTP-binding protein of the ARF family. Regad, F., Bardet, C., Tremousaygue, D., Moisan, A., Lescure, B., Axelos, M. FEBS Lett. (1993) [Pubmed]
Molecular and biochemical analyses of OsRab7, a rice Rab7 homolog. Nahm, M.Y., Kim, S.W., Yun, D., Lee, S.Y., Cho, M.J., Bahk, J.D. Plant Cell Physiol. (2003) [Pubmed]

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AgaP_AGAP001211	Anopheles gambiae str. PEST
AT5G59840	Arabidopsis thaliana
RAB8	Arabidopsis thaliana
AGOS_AGL021W	Ashbya gossypii ATCC 10895
RAB8A	Bos taurus
rab-8	Caenorhabditis elegans
RAB8A	Canis lupus familiaris
rab8a	Danio rerio
Rab8	Drosophila melanogaster
RAB8A	Gallus gallus
RAB8A	Homo sapiens
KLLA0E12079g	Kluyveromyces lactis NRRL Y-1140
MGG_06135	Magnaporthe oryzae 70-15
Rab8a	Mus musculus
NCU06404	Neurospora crassa OR74A
Os03g0819900	Oryza sativa Japonica Group
Os05g0461300	Oryza sativa Japonica Group
Os07g0239400	Oryza sativa Japonica Group
RAB8A	Pan troglodytes
Rab8a	Rattus norvegicus
SEC4	Saccharomyces cerevisiae S288c
ypt2	Schizosaccharomyces pombe 972h-
rab8a	Xenopus (Silurana) tropicalis

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