Gene Review:
RAB8A - RAB8A, member RAS oncogene family
Homo sapiens
Synonyms:
MEL, Oncogene c-mel, RAB8, Ras-related protein Rab-8A
- Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. Huber, L.A., Pimplikar, S., Parton, R.G., Virta, H., Zerial, M., Simons, K. J. Cell Biol. (1993)
- The MEL gene: a new member of the RAB/YPT class of RAS-related genes. Nimmo, E.R., Sanders, P.G., Padua, R.A., Hughes, D., Williamson, R., Johnson, K.J. Oncogene (1991)
- Transfer of genes into hematopoietic cells using recombinant DNA viruses. Karlsson, S., Humphries, R.K., Gluzman, Y., Nienhuis, A.W. Proc. Natl. Acad. Sci. U.S.A. (1985)
- High-dose therapy for refractory multiple myeloma: improved prognosis with better supportive care and double transplants. Vesole, D.H., Barlogie, B., Jagannath, S., Cheson, B., Tricot, G., Alexanian, R., Crowley, J. Blood (1994)
- A human endogenous retroviral sequence encoding an antigen recognized on melanoma by cytolytic T lymphocytes. Schiavetti, F., Thonnard, J., Colau, D., Boon, T., Coulie, P.G. Cancer Res. (2002)
- Reconfirming the role of life events for the timing of depressive episodes. A two-year prospective follow-up study. Mundt, C., Reck, C., Backenstrass, M., Kronmüller, K., Fiedler, P. Journal of affective disorders. (2000)
- Effects of tamoxifen and melatonin on mammary gland cancer induced by N-methyl-N-nitrosourea and by 7,12-dimethylbenz(a)anthracene, respectively, in female Sprague-Dawley rats. Kubatka, P., Bojková, B., M ciková-Kalická, K., Mníchová-Chamilová, M., Adámeková, E., Ahlers, I., Ahlersová, E., Cermáková, M. Folia Biol. (Praha) (2001)
- Analysis of human hemoglobin switching in MEL x human fetal erythroid cell hybrids. Papayannopoulou, T., Brice, M., Stamatoyannopoulos, G. Cell (1986)
- DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells. Wright, S., Rosenthal, A., Flavell, R., Grosveld, F. Cell (1984)
- Neutrophil influx into an inflammatory site inhibited by a soluble homing receptor-IgG chimaera. Watson, S.R., Fennie, C., Lasky, L.A. Nature (1991)
- Rab8-dependent Recycling Promotes Endosomal Cholesterol Removal in Normal and Sphingolipidosis Cells. Linder, M.D., Uronen, R.L., H??ltt??-Vuori, M., van der Sluijs, P., Per??nen, J., Ikonen, E. Mol. Biol. Cell (2007)
- Tyrosine transport in a human melanoma cell line as a basis for selective transport of cytotoxic analogues. Pankovich, J.M., Jimbow, K. Biochem. J. (1991)
- Phase I study for poor-prognosis lymphoma: augmentation of the "BEAM" regimen with escalating dose melphalan using amifostine cytoprotection and autologous hematopoietic stem cell transplantation--a preliminary report. Phillips, G.L., Abboud, C.N., Bernstein, S.H., Friedberg, J.W., Ifthikharuddin, J.J., Lancet, J.E., Liesveld, J.L., Spreng, E., Johnson, V., Chapman, M., Vesole, D.H. Semin. Oncol. (2004)
- Synergistic interactions between interferon beta and carboplatin on SK-MEL 28 human melanoma cell growth inhibition in vitro. Hübner, B., Eckert, K., Garbe, C., Maurer, H.R. J. Cancer Res. Clin. Oncol. (1995)
- In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. Ren, M., Zeng, J., De Lemos-Chiarandini, C., Rosenfeld, M., Adesnik, M., Sabatini, D.D. Proc. Natl. Acad. Sci. U.S.A. (1996)
- FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis. Hattula, K., Peränen, J. Curr. Biol. (2000)
- Characterization of the Rab8-specific membrane traffic route linked to protrusion formation. Hattula, K., Furuhjelm, J., Tikkanen, J., Tanhuanp????, K., Laakkonen, P., Per??nen, J. J. Cell. Sci. (2006)
- Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases. Wilson, A.L., Erdman, R.A., Castellano, F., Maltese, W.A. Biochem. J. (1998)
- Confirmation and refinement of the localisation of the c-MEL locus on chromosome 19 by physical and genetic mapping. Nimmo, E., Padua, R.A., Hughes, D., Brook, J.D., Williamson, R., Johnson, K.J. Hum. Genet. (1989)
- Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts. Peränen, J., Auvinen, P., Virta, H., Wepf, R., Simons, K. J. Cell Biol. (1996)
- Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins. Karniguian, A., Zahraoui, A., Tavitian, A. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Phosphoinositides, ezrin/moesin, and rac1 regulate fusion of rhodopsin transport carriers in retinal photoreceptors. Deretic, D., Traverso, V., Parkins, N., Jackson, F., Rodriguez de Turco, E.B., Ransom, N. Mol. Biol. Cell (2004)
- A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. Hattula, K., Furuhjelm, J., Arffman, A., Peränen, J. Mol. Biol. Cell (2002)
- MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. Bravo-Cordero, J.J., Marrero-Diaz, R., Megías, D., Genís, L., García-Grande, A., García, M.A., Arroyo, A.G., Montoya, M.C. EMBO J. (2007)
- Isoprenylation of Rab proteins possessing a C-terminal CaaX motif. Joberty, G., Tavitian, A., Zahraoui, A. FEBS Lett. (1993)
- rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain. Elferink, L.A., Anzai, K., Scheller, R.H. J. Biol. Chem. (1992)
- ADPKD: a human disease altering Golgi function and basolateral exocytosis in renal epithelia. Charron, A.J., Bacallao, R.L., Wandinger-Ness, A. Traffic (2000)
- Expression and release of interleukin-1 by different human melanoma cell lines. Köck, A., Schwarz, T., Urbanski, A., Peng, Z., Vetterlein, M., Micksche, M., Ansel, J.C., Kung, H.F., Luger, T.A. J. Natl. Cancer Inst. (1989)
- Design, expression, purification, and characterization, in vitro and in vivo, of an antimelanoma single-chain Fv antibody fused to the toxin gelonin. Rosenblum, M.G., Cheung, L.H., Liu, Y., Marks, J.W. Cancer Res. (2003)
- Characterization and purification of a mammalian endoribonuclease specific for the alpha -globin mRNA. Rodgers, N.D., Wang, Z., Kiledjian, M. J. Biol. Chem. (2002)