The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Rab8a  -  RAB8A, member RAS oncogene family

Rattus norvegicus

Synonyms: Mel, Rab8, Ras-related protein Rab-8A
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Rab8a

  • We have identified Rab8, a vesicular transport protein associated with trans-Golgi network membranes, as a critical component of the cellular machinery that delivers AMPA-type glutamatergic receptors (AMPARs) into synapses [1].
  • Using electron microscopic techniques, we have found that Rab8 is localized in close proximity to the synaptic membrane, including the postsynaptic density [1].
  • Electrophysiological studies indicated that Rab8 is necessary for the synaptic delivery of AMPARs during plasticity (long-term potentiation) and during constitutive receptor cycling [1].
  • Rab8b, because of its homology with Rab8, has been suggested to function in vesicle transport to the plasma membrane [2].
  • Northern blot analysis reveals highest levels of expression of Rab8b in the spleen, testis and brain, which is in marked contrast to the tissue distribution of Rab8 [3].

Anatomical context of Rab8a

  • Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line, RBL.2H3 [3].


  1. Local control of AMPA receptor trafficking at the postsynaptic terminal by a small GTPase of the Rab family. Gerges, N.Z., Backos, D.S., Esteban, J.A. J. Biol. Chem. (2004) [Pubmed]
  2. Rab8b and its interacting partner TRIP8b are involved in regulated secretion in AtT20 cells. Chen, S., Liang, M.C., Chia, J.N., Ngsee, J.K., Ting, A.E. J. Biol. Chem. (2001) [Pubmed]
  3. Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line, RBL.2H3. Armstrong, J., Thompson, N., Squire, J.H., Smith, J., Hayes, B., Solari, R. J. Cell. Sci. (1996) [Pubmed]
WikiGenes - Universities