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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rab8a  -  RAB8A, member RAS oncogene family

Rattus norvegicus

Synonyms: Mel, Rab8, Ras-related protein Rab-8A
 
 
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High impact information on Rab8a

  • We have identified Rab8, a vesicular transport protein associated with trans-Golgi network membranes, as a critical component of the cellular machinery that delivers AMPA-type glutamatergic receptors (AMPARs) into synapses [1].
  • Using electron microscopic techniques, we have found that Rab8 is localized in close proximity to the synaptic membrane, including the postsynaptic density [1].
  • Electrophysiological studies indicated that Rab8 is necessary for the synaptic delivery of AMPARs during plasticity (long-term potentiation) and during constitutive receptor cycling [1].
  • Rab8b, because of its homology with Rab8, has been suggested to function in vesicle transport to the plasma membrane [2].
  • Northern blot analysis reveals highest levels of expression of Rab8b in the spleen, testis and brain, which is in marked contrast to the tissue distribution of Rab8 [3].
 

Anatomical context of Rab8a

  • Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line, RBL.2H3 [3].

References

  1. Local control of AMPA receptor trafficking at the postsynaptic terminal by a small GTPase of the Rab family. Gerges, N.Z., Backos, D.S., Esteban, J.A. J. Biol. Chem. (2004) [Pubmed]
  2. Rab8b and its interacting partner TRIP8b are involved in regulated secretion in AtT20 cells. Chen, S., Liang, M.C., Chia, J.N., Ngsee, J.K., Ting, A.E. J. Biol. Chem. (2001) [Pubmed]
  3. Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line, RBL.2H3. Armstrong, J., Thompson, N., Squire, J.H., Smith, J., Hayes, B., Solari, R. J. Cell. Sci. (1996) [Pubmed]
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