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Gene Review

Rab8a  -  RAB8A, member RAS oncogene family

Mus musculus

Synonyms: AA409338, Mel, Oncogene c-mel, Rab8, Ras-related protein Rab-8A
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Disease relevance of Rab8a


High impact information on Rab8a

  • This translocation is dependent on the GTPase activity of Rab8, an interactor of optineurin [4].
  • Previously, we showed that the N-terminal Slp homology domain of Slp4-a interacts with the GTP-bound form of Rab3A, Rab8, and Rab27A both in vitro and in intact cells (Kuroda, T. S., Fukuda, M., Ariga, H., and Mikoshiba, K. (2002) J. Biol. Chem. 277, 9212-9218) [5].
  • Linkage and genetic distance were established for 10 loci by analysis of 114 meiotic events and indicated the following gene order: (centromere)-Insr-3.5 cM-Plat-26.3 cM-Crryps/Mel/Jund-3.5 cM-Junb/Ucp-10.5 cM-Mt-1-27.2 cM-Acta2-0.9 cM-Aprt [6].
  • Further, suppression of Rab8 expression by its antisense oligonucleotide revealed the reduction in staining intensity of Rab8 but not of Mel5, dendrite formation and melanosome transport towards the tips of the dendrites in B16 melanoma cells [2].
  • Since process formation is supported by cytoskeletal assembly as well as membrane transport, we tested the colocalization of Rab8 with actin filaments in B16 cells [2].

Biological context of Rab8a

  • Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus [4].
  • The viability of the parent K-12 strain in the cecal content of mice is significantly higher than that of its Mel- mutant phenotype [7].

Anatomical context of Rab8a


Associations of Rab8a with chemical compounds

  • Here, we present evidence that Rab8, a member of the small GTPase superfamily, is present in purified melanosomal fractions, and is upregulated by pigmentogenic agents like melanocyte-stimulating hormone/isobutylmethyl xanthine (MSH/IBMX) and ultraviolet radiation B (UVB) [2].


  1. Activation of N-ras in a human melanoma cell line. Padua, R.A., Barrass, N.C., Currie, G.A. Mol. Cell. Biol. (1985) [Pubmed]
  2. Evidence that the small GTPase Rab8 is involved in melanosome traffic and dendrite extension in B16 melanoma cells. Chakraborty, A.K., Funasaka, Y., Araki, K., Horikawa, T., Ichihashi, M. Cell Tissue Res. (2003) [Pubmed]
  3. Cellular genes possibly involved in the transformation process of the human melanoma cell line XP44 RO (Mel). Lafarge-Frayssinet, C., Daya-Grosjean, L., Estrade, S., Frezouls, G., Sarasin, A., Cassingena, R. Anticancer Res. (1995) [Pubmed]
  4. Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus. De Marco, N., Buono, M., Troise, F., Diez-Roux, G. J. Biol. Chem. (2006) [Pubmed]
  5. Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells. Fukuda, M., Kanno, E., Saegusa, C., Ogata, Y., Kuroda, T.S. J. Biol. Chem. (2002) [Pubmed]
  6. A linkage map of mouse chromosome 8: further definition of homologous linkage relationships between mouse chromosome 8 and human chromosomes 8, 16, and 19. Howard, T.A., Rochelle, J.M., Saunders, A.M., Seldin, M.F. Genomics (1991) [Pubmed]
  7. Feeding by mucin and intestinal growth of some enteric bacterial pathogens. Kétyi, I. Acta Microbiol. Hung. (1988) [Pubmed]
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